PMID- 33559512
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20220422
IS  - 1471-1788 (Electronic)
IS  - 1365-1501 (Linking)
VI  - 25
IP  - 1
DP  - 2021 Mar
TI  - The effects of childhood emotional maltreatment and alexithymia on depressive and 
      manic symptoms and suicidal ideation in females with bipolar disorder: emotion 
      dysregulation as a mediator.
PG  - 90-102
LID - 10.1080/13651501.2021.1879867 [doi]
AB  - OBJECTIVES: The relations of childhood emotional maltreatment and alexithymia to 
      the clinical course of bipolar disorder (BD) have been widely recognised. 
      Difficulties in regulating emotions may explain these relationships. The current 
      study evaluated the effects of childhood emotional maltreatment and alexithymia 
      on depressive and manic symptoms as well as suicidal ideation in female patients 
      with BD. Emotion dysregulation was evaluated as a mediating factor. METHODS: 
      Three hundred hospitalised female patients with a diagnosis of BD provided 
      information regarding their history of childhood emotional maltreatment, 
      alexithymia, difficulties in emotion regulation, depressive and manic symptoms, 
      and suicidal ideation. A series of structural equation models (SEMs) were 
      calculated to assess the associations between these variables. RESULTS: Childhood 
      emotional abuse and difficulty in identifying feelings were indirectly associated 
      with depressive and manic symptoms as well as suicidal ideation. This association 
      was mediated by emotion dysregulation. This association remained significant 
      after depressive and manic symptoms were controlled in the model. CONCLUSIONS: 
      This study indicates that patients with BD who experienced emotional abuse during 
      childhood and have difficulties identifying emotions report greater emotion 
      dysregulation. These individuals, in turn, are more likely to experience more 
      severe depressive and manic symptoms as well as suicidal ideation.Key 
      pointsChildhood emotional maltreatment and emotional and clinical factors in 
      bipolar disorder were assessed.Childhood emotional abuse indirectly affected 
      clinical factors via emotion dysregulation.Difficulty in identifying feelings was 
      linked to clinical factors via emotional dysregulation.Emotional dysregulation 
      affected the links of childhood emotional maltreatment and difficulty in 
      identifying feelings on suicidal ideation after controlling for clinical 
      symptoms.Emotional dysregulation dimensions of impulse, strategies, and goals 
      emerge in relation to suicidal ideation.
FAU - Khosravani, Vahid
AU  - Khosravani V
AUID- ORCID: 0000-0003-4314-0591
AD  - Behavioral Sciences Research Center, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Berk, Michael
AU  - Berk M
AUID- ORCID: 0000-0002-5554-6946
AD  - IMPACT - The Institute for Mental and Physical Health and Clinical Translation, 
      School of Medicine, Deakin University, Geelong, Australia.
AD  - Florey Institute for Neuroscience and Mental Health, University of Melbourne, 
      Melbourne, Australia.
AD  - Department of Psychiatry, Royal Melbourne Hospital, University of Melbourne, 
      Parkville, Australia.
AD  - Centre for Youth Mental Health, The University of Melbourne, Parkville, 
      Australia.
AD  - Orygen, Parkville, Australia.
FAU - Sharifi Bastan, Farangis
AU  - Sharifi Bastan F
AD  - Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, 
      Iran.
FAU - Samimi Ardestani, Seyed Mehdi
AU  - Samimi Ardestani SM
AD  - Departments of Psychiatry, Behavioral Sciences Research Center, Imam Hossein 
      Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Wrobel, Anna
AU  - Wrobel A
AD  - IMPACT - The Institute for Mental and Physical Health and Clinical Translation, 
      School of Medicine, Deakin University, Geelong, Australia.
AD  - Orygen, Parkville, Australia.
LA  - eng
PT  - Journal Article
DEP - 20210209
PL  - England
TA  - Int J Psychiatry Clin Pract
JT  - International journal of psychiatry in clinical practice
JID - 9709509
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Adult Survivors of Child Abuse
MH  - Affective Symptoms/*physiopathology
MH  - Bipolar Disorder/*physiopathology
MH  - Depression/*physiopathology
MH  - Emotional Regulation/*physiology
MH  - Female
MH  - Humans
MH  - Inpatients
MH  - Mania/*physiopathology
MH  - Middle Aged
MH  - *Suicidal Ideation
MH  - Young Adult
OTO - NOTNLM
OT  - Childhood emotional maltreatment
OT  - alexithymia
OT  - bipolar disorder
OT  - depression
OT  - emotion regulation
OT  - suicidal ideation
EDAT- 2021/02/10 06:00
MHDA- 2021/11/09 06:00
CRDT- 2021/02/09 08:42
PHST- 2021/02/10 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
PHST- 2021/02/09 08:42 [entrez]
AID - 10.1080/13651501.2021.1879867 [doi]
PST - ppublish
SO  - Int J Psychiatry Clin Pract. 2021 Mar;25(1):90-102. doi: 
      10.1080/13651501.2021.1879867. Epub 2021 Feb 9.