PMID- 33559856
OWN - NLM
STAT- MEDLINE
DCOM- 20210215
LR  - 20231213
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1290
DP  - 2021
TI  - IL-22 Signaling in the Tumor Microenvironment.
PG  - 81-88
LID - 10.1007/978-3-030-55617-4_5 [doi]
AB  - Interleukin (IL)-22 belongs to the IL-10 cytokine family which performs 
      biological functions by binding to heterodimer receptors comprising a type 1 
      receptor chain (R1) and a type 2 receptor chain (R2). IL-22 is mainly derived 
      from CD4+ helper T cells, CD8+ cytotoxic T cells, innate lymphocytes, and natural 
      killer T cells. It can activate downstream signaling pathways such as signal 
      transducer and activator of transcription (STAT)1/3/5, nuclear factor 
      kappa-light-chain-enhancer of activated B cells (NF-kappaB), mitogen-activated 
      protein kinase (MAPK), and phosphoinositide 3-kinase (PI3K)-protein kinase B 
      (AKT)-mammalian target of rapamycin (mTOR) through these heterodimer receptors. 
      Although IL-22 is produced by immune cells, its specific receptor IL-22R1 is 
      selectively expressed in nonimmune cells, such as hepatocytes, colonic epithelial 
      cells, and pancreatic epithelial cells (Jiang et al. Hepatology 54(3):900-9, 
      2011; Jiang et al. BMC Cancer 13:59, 2013; Curd et al. Clin Exp Immunol 
      168(2):192-9, 2012). Immune cells do not respond to IL-22 stimulation directly 
      within tumors, reports from different groups have revealed that IL-22 can 
      indirectly regulate the tumor microenvironment (TME). In the present chapter, we 
      discuss the roles of IL-22 in malignant cells and immunocytes within the TME, 
      meanwhile, the potential roles of IL-22 as a target for drug discovery will be 
      discussed.
FAU - Jiang, Runqiu
AU  - Jiang R
AD  - Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of 
      Nanjing University Medical School, Nanjing, People's Republic of China.
AD  - Medical School of Nanjing University, Nanjing, People's Republic of China.
FAU - Sun, Beicheng
AU  - Sun B
AD  - Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of 
      Nanjing University Medical School, Nanjing, People's Republic of China. 
      sunbc@nju.edu.cn.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Interleukins)
SB  - IM
MH  - Interleukins
MH  - *Phosphatidylinositol 3-Kinases
MH  - Signal Transduction
MH  - *Tumor Microenvironment
MH  - Interleukin-22
OTO - NOTNLM
OT  - Breast cancer
OT  - Colorectal cancer
OT  - Drug discovery
OT  - Gastric cancer
OT  - IL-22
OT  - Innate lymphocyte
OT  - JAK/STAT
OT  - Leukemia
OT  - Liver cancer
OT  - Lung cancer
OT  - Lymphoma
OT  - NKT cell
OT  - Pancreatic cancer
OT  - T cell
OT  - Tumor microenvironment
EDAT- 2021/02/10 06:00
MHDA- 2021/02/16 06:00
CRDT- 2021/02/09 08:49
PHST- 2021/02/09 08:49 [entrez]
PHST- 2021/02/10 06:00 [pubmed]
PHST- 2021/02/16 06:00 [medline]
AID - 10.1007/978-3-030-55617-4_5 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2021;1290:81-88. doi: 10.1007/978-3-030-55617-4_5.