PMID- 33560890
OWN - NLM
STAT- MEDLINE
DCOM- 20211223
LR  - 20211223
IS  - 1555-9823 (Electronic)
IS  - 0003-1348 (Linking)
VI  - 88
IP  - 1
DP  - 2022 Jan
TI  - Proton Pump Inhibitors, Associated Complications, and Alternative Therapies: A 
      Shifting Risk Benefit Ratio.
PG  - 20-27
LID - 10.1177/0003134821991988 [doi]
AB  - OBJECTIVE: Our goal was to compile the most recent and accurate data on the side 
      effects of proton pump inhibitors (PPI). We also compared the efficacy of PPI to 
      the efficacy of different surgical options for acid reflux control. BACKGROUND: 
      Proton pump inhibitors are the primary therapy for chronic control of 
      gastroesophageal reflux disease (GERD), but newer studies demonstrate deleterious 
      side effects. Collating this information and contrasting it with surgical therapy 
      for GERD provides evidence for possible practice changes in treatment. METHODS: A 
      literature search utilizing PubMed was performed evaluating for PPI and 
      anti-reflux surgery (ARS), focusing on articles that reflected information 
      regarding the usage and efficacy of symptom control of both PPI and ARS. Search 
      terms included "ARS, fundoplication, MSA, acute interstitial nephritis, acute 
      kidney injury, chronic kidney disease, meta-analysis, PPI, H(2) blocker, 
      cardiovascular risk, and gut dysbiosis." We evaluated 271 articles by title, 
      abstract, and data for relevance and included 70. RESULTS: Long-term control of 
      GERD with PPI may have a greater than expected side effect profile than initially 
      thought. Surgical options may provide greater symptom control than PPI without 
      the side effects of long-term medical therapy. CONCLUSIONS: Anti-reflux control 
      can be safely achieved with either PPI or surgical options; however, the 
      long-term side effects noted in the review such as increased risk of 
      cardiovascular events, renal disease, and gut dysbiosis may suggest surgical 
      anti-reflux control as a better long-term option.
FAU - Friedman, Alexander J
AU  - Friedman AJ
AD  - General Surgery Department, 19911Dwight D. Eisenhower Army Medical Center, Fort 
      Gordon, GA, USA.
FAU - Elseth, Anna J
AU  - Elseth AJ
AD  - General Surgery Department, 19911Dwight D. Eisenhower Army Medical Center, Fort 
      Gordon, GA, USA.
FAU - Brockmeyer, Joel R
AU  - Brockmeyer JR
AD  - General Surgery Department, 19911Dwight D. Eisenhower Army Medical Center, Fort 
      Gordon, GA, USA.
LA  - eng
PT  - Journal Article
DEP - 20210209
PL  - United States
TA  - Am Surg
JT  - The American surgeon
JID - 0370522
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Acute Kidney Injury/chemically induced
MH  - Dysbiosis/chemically induced
MH  - Fundoplication/methods
MH  - Gastroesophageal Reflux/*drug therapy/*surgery
MH  - Hepatic Encephalopathy/chemically induced
MH  - Humans
MH  - Magnets
MH  - Myocardial Infarction/chemically induced
MH  - Nephritis, Interstitial/chemically induced
MH  - Proton Pump Inhibitors/*adverse effects/therapeutic use
MH  - Renal Insufficiency, Chronic/chemically induced
MH  - Risk Assessment
MH  - Stroke/chemically induced
OTO - NOTNLM
OT  - fundoplication
OT  - gastrointestinal reflux disease
OT  - magnetic sphincter
OT  - proton pump inhibitors
EDAT- 2021/02/10 06:00
MHDA- 2021/12/24 06:00
CRDT- 2021/02/09 17:09
PHST- 2021/02/10 06:00 [pubmed]
PHST- 2021/12/24 06:00 [medline]
PHST- 2021/02/09 17:09 [entrez]
AID - 10.1177/0003134821991988 [doi]
PST - ppublish
SO  - Am Surg. 2022 Jan;88(1):20-27. doi: 10.1177/0003134821991988. Epub 2021 Feb 9.