PMID- 33561154
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20231110
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Print)
IS  - 1935-2727 (Linking)
VI  - 15
IP  - 2
DP  - 2021 Feb
TI  - Paracoccidioimycosis and white individuals: Susceptibility and biogeographic 
      aspects in an important endemic area in Brazil.
PG  - e0009086
LID - 10.1371/journal.pntd.0009086 [doi]
LID - e0009086
AB  - Paracoccidioidomycosis (PCM) is a neglected mycosis most commonly occurring in 
      Latin America. The etiologic agents are thermo dimorphic fungi of the genus 
      Paracoccidioides, and cause an important granulomatous response in affected 
      tissues. The Botucatu Medical School, from Sao Paulo State University (UNESP), is 
      a PCM study pole, located in Sao Paulo State Midwest region, which is classified 
      as a hyperendemic area in the Southeast region in Brazil. This study aimed to 
      perform a retrospective epidemiological, geographical, and clinical analysis by 
      the information available in medical records. It was listed as socio-demographic 
      data along with clinical characteristics from patients diagnosed and treated 
      during a 10-year period in Botucatu, totaling 177 patients with 
      Paracoccidioidomycosis confirmed by the histopathological test. It was observed 
      that the main clinical presentation was the chronic type (76,3%), most commonly 
      identified in white male individuals over the age of 29 years old, smokers, and 
      alcoholics, providing evidences for the first time that white individuals were 
      more affected by the disease, in comparison to non-white individuals that may be 
      more resistant to infection. This data opens new avenues for study within 
      ancestry, resistance and susceptibility in paracoccidioidomycosis.
FAU - Zeminian de Oliveira, Luciana Bonome
AU  - Zeminian de Oliveira LB
AD  - Sao Paulo State University (UNESP), Medical School of Botucatu, Laboratory of 
      Immunopathology and Infectious Agents-LIAI, UNIPEX-Experimental Research Unity, 
      Sector 5, Botucatu, Sao Paulo State, Brazil.
FAU - Della Coletta, Amanda Manoel
AU  - Della Coletta AM
AUID- ORCID: 0000-0002-6166-8982
AD  - Sao Paulo State University (UNESP), Medical School of Botucatu, Laboratory of 
      Immunopathology and Infectious Agents-LIAI, UNIPEX-Experimental Research Unity, 
      Sector 5, Botucatu, Sao Paulo State, Brazil.
FAU - Gardizani, Taiane Priscila
AU  - Gardizani TP
AUID- ORCID: 0000-0002-3903-334X
AD  - Sao Paulo State University (UNESP), Medical School of Botucatu, Laboratory of 
      Immunopathology and Infectious Agents-LIAI, UNIPEX-Experimental Research Unity, 
      Sector 5, Botucatu, Sao Paulo State, Brazil.
FAU - Barrozo, Ligia Vizeu
AU  - Barrozo LV
AUID- ORCID: 0000-0001-7322-6789
AD  - University of Sao Paulo (USP), Department of Geography, School of Philosophy, 
      Literature and Human Sciences, Sao Paulo, Sao Paulo State, Brazil.
FAU - Miot, Helio Amante
AU  - Miot HA
AD  - Sao Paulo State University (UNESP), Medical School of Botucatu, Division of 
      Dermatology and Radiotherapy, Botucatu, Sao Paulo State, Brazil.
FAU - De Faveri, Julio
AU  - De Faveri J
AD  - Sao Paulo State University (UNESP), Medical School of Botucatu, Department of 
      Pathology, Botucatu/SP-Brazil.
FAU - Dias-Melicio, Luciane Alarcao
AU  - Dias-Melicio LA
AUID- ORCID: 0000-0001-9254-2074
AD  - Sao Paulo State University (UNESP), Medical School of Botucatu, Laboratory of 
      Immunopathology and Infectious Agents-LIAI, UNIPEX-Experimental Research Unity, 
      Sector 5, Botucatu, Sao Paulo State, Brazil.
AD  - Sao Paulo State University (UNESP), Medical School of Botucatu, Department of 
      Pathology, Botucatu/SP-Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210209
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brazil/epidemiology
MH  - *Disease Susceptibility
MH  - Ethnicity
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Paracoccidioides
MH  - Paracoccidioidomycosis/diagnosis/*microbiology/therapy
MH  - Pregnancy
MH  - Retrospective Studies
MH  - Young Adult
PMC - PMC7899320
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/02/10 06:00
MHDA- 2021/06/23 06:00
PMCR- 2021/02/09
CRDT- 2021/02/09 17:12
PHST- 2020/03/27 00:00 [received]
PHST- 2020/12/22 00:00 [accepted]
PHST- 2021/02/22 00:00 [revised]
PHST- 2021/02/10 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2021/02/09 17:12 [entrez]
PHST- 2021/02/09 00:00 [pmc-release]
AID - PNTD-D-20-00505 [pii]
AID - 10.1371/journal.pntd.0009086 [doi]
PST - epublish
SO  - PLoS Negl Trop Dis. 2021 Feb 9;15(2):e0009086. doi: 10.1371/journal.pntd.0009086. 
      eCollection 2021 Feb.