PMID- 3356124
OWN - NLM
STAT- MEDLINE
DCOM- 19880516
LR  - 20190816
IS  - 0305-0491 (Print)
IS  - 0305-0491 (Linking)
VI  - 89
IP  - 1
DP  - 1988
TI  - Guanine nucleotide binding in human placental syncytiotrophoblast membranes and 
      comparative regulation of adenylate cyclase in syncytiotrophoblast, turkey 
      erythrocyte and bovine calf testes membranes by guanosine-5'-triphosphate.
PG  - 119-25
AB  - Guanosine-5'-triphosphate (GTP) binds specifically to syncytiotrophoblast plasma 
      membranes and increases the production of cyclic AMP in these membranes. 1. In 
      syncytiotrophoblast membranes, GTP alone caused a significant increase in the 
      basal levels of cyclic AMP in a dose dependent manner. 2. GTP alone did not 
      significantly stimulate cyclic AMP production in turkey erythrocyte or bovine 
      calf testes membranes. 3. GTP decreased Gpp(NH)p-mediated cyclic AMP production 
      while increasing NaF-mediated cyclic AMP production in placental, erythrocyte and 
      testes membranes. 4. Since cyclic AMP has been reported to regulate the levels of 
      placental hormones, and it is shown in this study that GTP increases cyclic AMP 
      production in the placenta, this study suggests: (A) placental GTP levels may 
      indirectly regulate placental hormone production, (B) placental beta adrenergic 
      (BA) mediated adenylate cyclase activity may not be regulated in the same manner 
      as the BA system of avian erythrocytes.
FAU - Figgs, L W
AU  - Figgs LW
AD  - Department of Biochemistry, Albany Medical College of Union University, NY 12208.
LA  - eng
GR  - HD-07252/HD/NICHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Comp Biochem Physiol B
JT  - Comparative biochemistry and physiology. B, Comparative biochemistry
JID - 2984730R
RN  - 0 (Guanine Nucleotides)
RN  - 34273-04-6 (Guanylyl Imidodiphosphate)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - EC 4.6.1.1 (Adenylyl Cyclases)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Adenylyl Cyclases/*metabolism
MH  - Animals
MH  - Cattle
MH  - Erythrocytes/*enzymology
MH  - Guanine Nucleotides/*metabolism
MH  - Guanosine Triphosphate/*pharmacology
MH  - Guanylyl Imidodiphosphate/metabolism
MH  - Humans
MH  - Isoproterenol/pharmacology
MH  - Male
MH  - Membranes/enzymology
MH  - Placenta/cytology
MH  - Testis/*enzymology
MH  - Trophoblasts/*metabolism
MH  - Turkeys
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1016/0305-0491(88)90271-4 [doi]
PST - ppublish
SO  - Comp Biochem Physiol B. 1988;89(1):119-25. doi: 10.1016/0305-0491(88)90271-4.