PMID- 33564729
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220420
IS  - 2432-1354 (Electronic)
IS  - 2432-1354 (Linking)
VI  - 6
DP  - 2021
TI  - Functionally Relevant Threshold of Quadriceps Muscle Strength in Patients with 
      Chronic Obstructive Pulmonary Disease.
PG  - 20210008
LID - 10.2490/prm.20210008 [doi]
LID - 20210008
AB  - OBJECTIVES: We aimed to identify the quadriceps muscle strength (QMS) thresholds 
      below which exercise capacity is compromised in men with chronic obstructive 
      pulmonary disease (COPD). METHODS: We measured the quadriceps isometric maximum 
      voluntary contraction (QMVC) and calculated the QMVC values normalized to weight 
      (QMVC-BW), height squared (QMVC-H(2)), and body mass index (QMVC-BMI) in 113 
      patients with COPD. The functional exercise capacity was evaluated using the 
      6-minute walk distance (6MWD), and 6MWD <350 m was defined as functional exercise 
      intolerance. Thresholds were determined for QMVC and its normalized values to 
      achieve high specificity (>0.90) with maximal sensitivity. P-values <0.01 were 
      considered statistically significant. RESULTS: Data from 99 male patients (age, 
      74 +/- 6 years; percentages of predicted forced expiratory volume in 1-s, 56.9 +/- 
      26.4%) were analyzed; 3 women and 11 participants with the missing data were 
      excluded. Multivariate logistic regression models identified significant 
      associations of QMVC and QMVC-H(2) with 6MWD, after adjustment for age and 
      dyspnea. C-statistics showed that the area under the curves of all QMVC 
      parameters were comparable. The thresholds of QMVC and QMVC-H(2) for predicting 
      compromised exercise capacity were 26.2 kg and 9.6 kg/m(2), respectively. 
      CONCLUSIONS: QMS thresholds in men with COPD could help clinicians evaluate 
      whether QMS is insufficient to achieve 6MWD >/=350 m and thereby identify patients 
      who should be specifically targeted for muscle strengthening training during 
      their pulmonary rehabilitation program.
CI  - (c)2021 The Japanese Association of Rehabilitation Medicine.
FAU - Iwakura, Masahiro
AU  - Iwakura M
AD  - Department of Rehabilitation, Akita City Hospital, Akita, Japan.
FAU - Wakasa, Masahiko
AU  - Wakasa M
AD  - Department of Physical Therapy, Akita University Graduate School of Health 
      Sciences, Akita, Japan.
FAU - Okura, Kazuki
AU  - Okura K
AD  - Department of Rehabilitation, Akita University Hospital, Akita, Japan.
FAU - Kawagoshi, Atsuyoshi
AU  - Kawagoshi A
AD  - Department of Rehabilitation, Akita City Hospital, Akita, Japan.
FAU - Sugawara, Keiyu
AU  - Sugawara K
AD  - Department of Rehabilitation, Akita City Hospital, Akita, Japan.
FAU - Takahashi, Hitomi
AU  - Takahashi H
AD  - Department of Physical Therapy, School of Health Science, International 
      University of Health and Welfare, Ohtawara, Japan.
FAU - Shioya, Takanobu
AU  - Shioya T
AD  - Department of Physical Therapy, Akita University Graduate School of Health 
      Sciences, Akita, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210206
PL  - Japan
TA  - Prog Rehabil Med
JT  - Progress in rehabilitation medicine
JID - 101707740
PMC - PMC7862007
OTO - NOTNLM
OT  - chronic obstructive
OT  - exercise tolerance
OT  - muscle strength
OT  - pulmonary disease
OT  - quadriceps muscle
COIS- CONFLICTS OF INTEREST: The authors have no competing interests to declare.
EDAT- 2021/02/11 06:00
MHDA- 2021/02/11 06:01
PMCR- 2021/02/06
CRDT- 2021/02/10 05:57
PHST- 2020/09/10 00:00 [received]
PHST- 2021/01/20 00:00 [accepted]
PHST- 2021/02/10 05:57 [entrez]
PHST- 2021/02/11 06:00 [pubmed]
PHST- 2021/02/11 06:01 [medline]
PHST- 2021/02/06 00:00 [pmc-release]
AID - 20210008 [pii]
AID - 10.2490/prm.20210008 [doi]
PST - epublish
SO  - Prog Rehabil Med. 2021 Feb 6;6:20210008. doi: 10.2490/prm.20210008. eCollection 
      2021.