PMID- 33564844
OWN - NLM
STAT- MEDLINE
DCOM- 20210420
LR  - 20230214
IS  - 1938-3207 (Electronic)
IS  - 0002-9165 (Linking)
VI  - 113
IP  - 4
DP  - 2021 Apr 6
TI  - The effect of daily protein supplementation, with or without resistance training 
      for 1 year, on muscle size, strength, and function in healthy older adults: A 
      randomized controlled trial.
PG  - 790-800
LID - 10.1093/ajcn/nqaa372 [doi]
AB  - BACKGROUND: Protein supplementation alone or combined with resistance training 
      has been proposed to be effective in counteracting age-related losses of muscle 
      mass and strength. OBJECTIVES: To investigate the effect of protein 
      supplementation alone or combined with light-intensity or heavy-load resistance 
      exercise on muscle size, strength, and function in older adults. METHODS: In a 
      1-y randomized controlled trial, 208 healthy older adults (>65 y) were randomly 
      assigned to 1 of 5 interventions: 1) carbohydrate supplementation (CARB); 2) 
      collagen protein supplementation (COLL); 3) whey protein supplementation (WHEY); 
      4) light-intensity resistance training 3-5 times/wk with whey protein 
      supplementation (LITW); and 5) heavy resistance training 3 times weekly with whey 
      protein supplementation (HRTW). Protein supplements contained 20 g protein + 10 g 
      carbohydrate, whereas CARB contained 30 g of carbohydrates. All intervention 
      groups received the supplement twice daily. The primary outcome was change in the 
      quadriceps cross-sectional area (qCSA). Secondary outcomes included measures of 
      lower extremity strength and power, functional capabilities, and body 
      composition. RESULTS: There were 184 participants who completed the study. COLL 
      and WHEY did not affect any measured parameter compared to CARB. Compared to 
      WHEY, HRTW improved the qCSA size (between-group difference, +1.68 cm2; 95% CI, 
      +0.41 to +2.95 cm2; P = 0.03), as well as dynamic (+18.4 Nm; 95% CI, +10.1 to 
      +26.6 Nm; P < 10-4) and isometric knee extensor strength (+23.9 Nm; 95% CI, +14.2 
      to +33.6 Nm; P < 10-5). LITW did not improve the qCSA size, but increased dynamic 
      knee extensor strength compared to WHEY (+13.7 Nm; 95% CI, +5.3 and +22.1 Nm; 
      P = 0.01). CONCLUSIONS: Recommending protein supplementation as a stand-alone 
      intervention for healthy older individuals seems ineffective in improving muscle 
      mass and strength. Only HRTW was effective in both preserving muscle mass and 
      increasing strength. Thus, we recommend that future studies investigate 
      strategies to increase long-term compliance to heavy resistance exercise in 
      healthy older adults. This trial was registered at clinicaltrials.gov as 
      NCT02034760.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      American Society for Nutrition.
FAU - Mertz, Kenneth H
AU  - Mertz KH
AD  - Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg 
      Hospital, Copenhagen, Denmark.
FAU - Reitelseder, Soren
AU  - Reitelseder S
AD  - Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg 
      Hospital, Copenhagen, Denmark.
AD  - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Bechshoeft, Rasmus
AU  - Bechshoeft R
AD  - Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg 
      Hospital, Copenhagen, Denmark.
FAU - Bulow, Jacob
AU  - Bulow J
AD  - Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg 
      Hospital, Copenhagen, Denmark.
FAU - Hojfeldt, Grith
AU  - Hojfeldt G
AD  - Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg 
      Hospital, Copenhagen, Denmark.
FAU - Jensen, Mikkel
AU  - Jensen M
AD  - Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg 
      Hospital, Copenhagen, Denmark.
FAU - Schacht, Simon R
AU  - Schacht SR
AD  - Vitality Centre for Good Older Lives, Department of Nutrition, Exercise and 
      Sports, University of Copenhagen, Copenhagen, Denmark.
FAU - Lind, Mads Vendelbo
AU  - Lind MV
AD  - Vitality Centre for Good Older Lives, Department of Nutrition, Exercise and 
      Sports, University of Copenhagen, Copenhagen, Denmark.
FAU - Rasmussen, Morten A
AU  - Rasmussen MA
AD  - Department of Food Science, University of Copenhagen, Copenhagen, Denmark.
FAU - Mikkelsen, Ulla R
AU  - Mikkelsen UR
AD  - Arla Foods Ingredients Group P/S, Viby, Denmark.
FAU - Tetens, Inge
AU  - Tetens I
AD  - Vitality Centre for Good Older Lives, Department of Nutrition, Exercise and 
      Sports, University of Copenhagen, Copenhagen, Denmark.
FAU - Engelsen, Soren B
AU  - Engelsen SB
AD  - Department of Food Science, University of Copenhagen, Copenhagen, Denmark.
FAU - Nielsen, Dennis S
AU  - Nielsen DS
AD  - Department of Food Science, University of Copenhagen, Copenhagen, Denmark.
FAU - Jespersen, Astrid P
AU  - Jespersen AP
AD  - Copenhagen Center for Health Research in the Humanities, Saxo-Institute, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Holm, Lars
AU  - Holm L
AD  - Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg 
      Hospital, Copenhagen, Denmark.
AD  - Department of Biomedical Sciences, Faculty of Health and Medical Sciences, 
      University of Copenhagen, Copenhagen, Denmark.
AD  - School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, 
      Birmingham, United Kingdom.
LA  - eng
SI  - ClinicalTrials.gov/NCT02034760
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Dietary Proteins)
RN  - 0 (Whey Proteins)
SB  - IM
MH  - Aged
MH  - Dietary Proteins/*administration & dosage
MH  - *Dietary Supplements
MH  - Female
MH  - Humans
MH  - Male
MH  - Muscle Strength/*drug effects
MH  - Muscle, Skeletal/*drug effects
MH  - Patient Compliance
MH  - Physical Functional Performance
MH  - *Resistance Training
MH  - Whey Proteins/administration & dosage/*pharmacology
OTO - NOTNLM
OT  - ageing
OT  - exercise
OT  - protein supplementation
OT  - randomized controlled trials
OT  - resistance training
OT  - skeletal muscle
EDAT- 2021/02/11 06:00
MHDA- 2021/04/21 06:00
CRDT- 2021/02/10 05:57
PHST- 2020/03/09 00:00 [received]
PHST- 2020/11/16 00:00 [accepted]
PHST- 2021/02/11 06:00 [pubmed]
PHST- 2021/04/21 06:00 [medline]
PHST- 2021/02/10 05:57 [entrez]
AID - S0002-9165(22)00647-5 [pii]
AID - 10.1093/ajcn/nqaa372 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2021 Apr 6;113(4):790-800. doi: 10.1093/ajcn/nqaa372.