PMID- 33565168
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20220531
IS  - 1439-0272 (Electronic)
IS  - 0303-4569 (Linking)
VI  - 53
IP  - 4
DP  - 2021 May
TI  - Oyster peptide prevents the occurrence of exercise-hypogonadal male condition by 
      improving the function of pituitary gonadal axis in male rats.
PG  - e14005
LID - 10.1111/and.14005 [doi]
AB  - This study evaluates the protective role of oyster peptide (OP) on the occurrence 
      of Exercise-Hypogonadal Male Condition. Male rats were given heavy-load swimming 
      training and / or OP was supplemented for 6 consecutive weeks. After heavy-load 
      training, sperm count, sperm viability and sperm motility in epididymis, 
      testosterone in serum and testis, glutathione peroxidase (GSH-px) and androgen 
      receptor (AR) in testis and mating times were remarkably decreased, 
      malondialdehyde (MDA), capture latency and mating latency were significantly 
      increased, mRNA expression of steroidogenic acute regulatory (StAR) and P450 
      cholesterol side-chain cleavage enzyme (P450scc) were obviously down-regulated, 
      but serum follicle-stimulating hormone (FSH) and luteinising hormone (LH) were 
      not statistically changed. Conversely, when OP was supplemented at heavy-load 
      training, sperm count, sperm viability and sperm motility in epididymis, serum 
      FSH, LH, testosterone, GSH-px, superoxide dismutase (SOD), testosterone, AR in 
      testis and mating times were dramatically increased, while testicular MDA, 
      capture latency and mating latency were significantly decreased, and mRNA 
      expression of StAR, StARD7, P450scc and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) 
      were significantly up-regulated. In conclusion, heavy-load training causes 
      testicular spermatogenic and steroidogenic disorders by enhancing the generation 
      of reactive oxygen species (ROS), which can be protected by the co-administration 
      of OP by enhancing the function of pituitary gonad axis and lowering ROS 
      generation.
CI  - (c) 2021 Wiley-VCH GmbH.
FAU - Jin, Qi-Guan
AU  - Jin QG
AUID- ORCID: 0000-0002-5539-8779
AD  - College of Physical Education, Yangzhou University, Yangzhou, China.
FAU - Shi, Wen-Ting
AU  - Shi WT
AD  - College of Physical Education, Yangzhou University, Yangzhou, China.
FAU - Wang, Yu-Chen
AU  - Wang YC
AD  - Beijing Engineering Research Center of Protein and Functional Peptides, China 
      National Research Institute of Food and Fermentation Industries Co., Ltd., 
      Beijing, China.
FAU - Li, Shu-Yan
AU  - Li SY
AD  - College of Physical Education, Yangzhou University, Yangzhou, China.
FAU - Xue, Chen
AU  - Xue C
AD  - Beijing Engineering Research Center of Protein and Functional Peptides, China 
      National Research Institute of Food and Fermentation Industries Co., Ltd., 
      Beijing, China.
FAU - Xu, Hao-Ran
AU  - Xu HR
AD  - College of Physical Education, Yangzhou University, Yangzhou, China.
FAU - Wu, Mei-Tong
AU  - Wu MT
AD  - College of Physical Education, Yangzhou University, Yangzhou, China.
FAU - Wei, Ying
AU  - Wei Y
AUID- ORCID: 0000-0002-0943-1793
AD  - Beijing Engineering Research Center of Protein and Functional Peptides, China 
      National Research Institute of Food and Fermentation Industries Co., Ltd., 
      Beijing, China.
LA  - eng
GR  - 2016YFD0400603/National Key Research and Development project in China/
GR  - 2017PFP002/Open Project of the Beijing Engineering Research Center of Protein and 
      Functional Peptides/
PT  - Journal Article
DEP - 20210210
PL  - Germany
TA  - Andrologia
JT  - Andrologia
JID - 0423506
RN  - 0 (Carrier Proteins)
RN  - 3XMK78S47O (Testosterone)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - Animals
MH  - Carrier Proteins
MH  - Luteinizing Hormone
MH  - Male
MH  - *Ostreidae
MH  - Rats
MH  - Sperm Count
MH  - *Sperm Motility
MH  - Testis
MH  - Testosterone
OTO - NOTNLM
OT  - exercise-hypogonadal male condition
OT  - oyster peptide
OT  - reactive oxygen species
OT  - spermatogenesis
OT  - steroidogenesis
EDAT- 2021/02/11 06:00
MHDA- 2021/06/22 06:00
CRDT- 2021/02/10 06:01
PHST- 2021/01/21 00:00 [revised]
PHST- 2020/12/04 00:00 [received]
PHST- 2021/01/22 00:00 [accepted]
PHST- 2021/02/11 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/02/10 06:01 [entrez]
AID - 10.1111/and.14005 [doi]
PST - ppublish
SO  - Andrologia. 2021 May;53(4):e14005. doi: 10.1111/and.14005. Epub 2021 Feb 10.