PMID- 33565327
OWN - NLM
STAT- MEDLINE
DCOM- 20220124
LR  - 20220124
IS  - 1752-0371 (Electronic)
IS  - 1752-0363 (Linking)
VI  - 15
IP  - 4
DP  - 2021 Mar
TI  - Lower levels of triiodothyronine are associated with poor hemodynamic profile and 
      all-cause mortality in heart failure.
PG  - 273-283
LID - 10.2217/bmm-2020-0425 [doi]
AB  - Background: We aimed to assess the association of triiodothyronine (T3) hormone 
      with invasive hemodynamic parameters and all-cause mortality in heart failure 
      with reduced ejection fraction (HFrEF). Results: About 483 HFrEF patients were 
      enrolled. Patients with the lowest T3 tertile had advanced New York Heart 
      Association (NYHA) classes, had higher uric acid, brain natriuretic peptide. T3 
      level had a positive correlation with cardiac index (CI) and a negative 
      correlation with pulmonary vascular resistance and pulmonary capillary wedge 
      pressure. Adjusted with NYHA III-IV classes, uric acid, aspartate 
      aminotransferase and CI, T3 level was found to be an independent predictor of 
      all-cause mortality. In Kaplan-Meier analysis, the lowest T3 tertile had the 
      lowest survival function. Conclusion: Free T3 is positively correlated with CI 
      and negatively correlated with pulmonary vascular resistance and pulmonary 
      capillary wedge pressure in patients with HFrEF. Lower levels of T3 seems to be a 
      poor prognostic factor in this particular patient population.
FAU - Cetin, Elif Ho
AU  - Cetin EH
AUID- ORCID: 0000-0001-5969-2345
AD  - Department of Cardiology, Ankara City Hospital, Ankara, Turkey.
FAU - Cetin, Mehmet S
AU  - Cetin MS
AD  - Etimesgut State Hospital, Cardiology Clinic, Ankara, Turkey.
FAU - Konte, Hasan C
AU  - Konte HC
AD  - Department of Cardiology, Ankara City Hospital, Ankara, Turkey.
FAU - Ocak, Kadir
AU  - Ocak K
AD  - Department of Cardiology, Ankara City Hospital, Ankara, Turkey.
FAU - Yaman, Nezaket M
AU  - Yaman NM
AD  - Department of Cardiology, Ankara City Hospital, Ankara, Turkey.
FAU - Hepsen, Sema
AU  - Hepsen S
AUID- ORCID: 0000-0002-8375-7409
AD  - Diskapi Education & Research Hospital, Endocrinology & Metabolic Disease Clinic, 
      Ankara, Turkey.
FAU - Ozeke, Ozcan
AU  - Ozeke O
AD  - Department of Cardiology, Ankara City Hospital, Ankara, Turkey.
FAU - Temizhan, Ahmet
AU  - Temizhan A
AD  - Department of Cardiology, Ankara City Hospital, Ankara, Turkey.
FAU - Topaloglu, Serkan
AU  - Topaloglu S
AD  - Department of Cardiology, Ankara City Hospital, Ankara, Turkey.
FAU - Aras, Dursun
AU  - Aras D
AD  - Department of Cardiology, Ankara City Hospital, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210210
PL  - England
TA  - Biomark Med
JT  - Biomarkers in medicine
JID - 101312535
RN  - 06LU7C9H1V (Triiodothyronine)
SB  - IM
MH  - Female
MH  - Heart Failure/metabolism/*mortality/pathology
MH  - *Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - *Stroke Volume
MH  - Survival Rate
MH  - Triiodothyronine/*deficiency
OTO - NOTNLM
OT  - cardiac catheterization
OT  - heart failure
OT  - hemodynamics
OT  - thyroid hormone
OT  - triiodothyronine
EDAT- 2021/02/11 06:00
MHDA- 2022/01/27 06:00
CRDT- 2021/02/10 08:37
PHST- 2021/02/11 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/02/10 08:37 [entrez]
AID - 10.2217/bmm-2020-0425 [doi]
PST - ppublish
SO  - Biomark Med. 2021 Mar;15(4):273-283. doi: 10.2217/bmm-2020-0425. Epub 2021 Feb 
      10.