PMID- 33567332
OWN - NLM
STAT- MEDLINE
DCOM- 20220207
LR  - 20220207
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 110
DP  - 2021 Aug 30
TI  - Sex differences in macular thickness of the retina in patients with psychosis 
      spectrum disorders.
PG  - 110280
LID - S0278-5846(21)00039-7 [pii]
LID - 10.1016/j.pnpbp.2021.110280 [doi]
AB  - INTRODUCTION: Imaging of retinal structure in psychosis spectrum disorders (PSD) 
      is a novel approach to studying effect of this illness class on CNS structure. 
      Studies of optical coherence tomography (OCT) have revealed significant 
      reductions in regarding: retinal nerve fiber layer (RNFL), macular thickness 
      (MT), ganglion cell-inner plexiform layer (GC-IPL) and macular volume (MV). Sex 
      differences in retinal structure in PSD have not been previously explored. 
      METHODS: This cross-sectional pilot study included 81 participant of age matched 
      patients and controls. There were no differences between genders regarding 
      illness duration and antipsychotic daily dose in the patient group. SD-OCT 
      assessed RNFL, GC-IPL, MT, MV, and optic nerve cup-to-disc (C/D) ratio. In order 
      to assess the main effects of illness, sex, and illness x sex interaction on the 
      retinal parameters, general linear model was performed. RESULTS: Patients 
      demonstrated abnormalities on all OCT indices. Effects of sex were observed for 
      central subfield MT and C/D ratio, which were lower in females. An illness x sex 
      interaction effect was observed for the left MT, indicating greater thinning in 
      female patients. CONCLUSION: Sex differences in OCT findings in PSD appear to be 
      most prominent considering macular parameters. These preliminary data may have 
      important implications for the valid interpretation of OCT findings as potential 
      biomarkers for PSD.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Jerotic, Stefan
AU  - Jerotic S
AD  - Clinic for Psychiatry, University Clinical Centre of Serbia, Belgrade, Serbia. 
      Electronic address: stefan.jerotic@gmail.com.
FAU - Lalovic, Nikola
AU  - Lalovic N
AD  - Clinic for Psychiatry, University Clinical Centre of Serbia, Belgrade, Serbia.
FAU - Pejovic, Slobodanka
AU  - Pejovic S
AD  - Clinic for Psychiatry, University Clinical Centre of Serbia, Belgrade, Serbia; 
      Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
FAU - Mihaljevic, Marina
AU  - Mihaljevic M
AD  - Clinic for Psychiatry, University Clinical Centre of Serbia, Belgrade, Serbia; 
      Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
FAU - Pavlovic, Zorana
AU  - Pavlovic Z
AD  - Clinic for Psychiatry, University Clinical Centre of Serbia, Belgrade, Serbia; 
      Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
FAU - Britvic, Dubravka
AU  - Britvic D
AD  - Clinic for Psychiatry, University Clinical Centre of Serbia, Belgrade, Serbia.
FAU - Risimic, Dijana
AU  - Risimic D
AD  - Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic for 
      Ophthalmology, University Clinical Centre of Serbia, Belgrade, Serbia.
FAU - Soldatovic, Ivan
AU  - Soldatovic I
AD  - Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
FAU - Silverstein, Steven M
AU  - Silverstein SM
AD  - Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, 
      USA.
FAU - Maric, Nadja P
AU  - Maric NP
AD  - Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Institute of 
      Mental Health, Belgrade, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20210207
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/therapeutic use
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Psychotic Disorders/*complications/drug therapy
MH  - Retina/diagnostic imaging/physiopathology
MH  - Sex Factors
MH  - *Tomography, Optical Coherence
OTO - NOTNLM
OT  - Macula
OT  - Optical coherence tomography
OT  - Psychosis spectrum disorders
OT  - Retina
OT  - Sex differences
EDAT- 2021/02/11 06:00
MHDA- 2022/02/08 06:00
CRDT- 2021/02/10 20:06
PHST- 2020/11/05 00:00 [received]
PHST- 2021/01/26 00:00 [revised]
PHST- 2021/02/05 00:00 [accepted]
PHST- 2021/02/11 06:00 [pubmed]
PHST- 2022/02/08 06:00 [medline]
PHST- 2021/02/10 20:06 [entrez]
AID - S0278-5846(21)00039-7 [pii]
AID - 10.1016/j.pnpbp.2021.110280 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2021 Aug 30;110:110280. doi: 
      10.1016/j.pnpbp.2021.110280. Epub 2021 Feb 7.