PMID- 33567513
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210316
IS  - 1424-8247 (Print)
IS  - 1424-8247 (Electronic)
IS  - 1424-8247 (Linking)
VI  - 14
IP  - 2
DP  - 2021 Feb 8
TI  - Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization 
      of the Medial Meniscus-Induced Animal Model.
LID - 10.3390/ph14020135 [doi]
LID - 135
AB  - Arthritis is a common inflammatory disease that causes pain, stiffness, and joint 
      swelling. Here, we investigated the ameliorative effects of loganin on arthritis 
      in vitro and in vivo. A single bioactive compound was fractionated and isolated 
      from Cornus officinalis (CO) extract to screen for anti-arthritic effects. A 
      single component, loganin, was identified as a candidate. The CO extract and 
      loganin inhibited the expression of factors associated with cartilage 
      degradation, such as cyclooxygenase-2 (COX-2), matrix metalloproteinase 3 
      (MMP-3), and matrix metalloproteinase 13 (MMP-13), in interukin-1 beta 
      (IL-1beta)-induced chondrocyte inflammation. In addition, prostaglandin and 
      collagenase levels were reduced following treatment of IL-1beta-induced chondrocytes 
      with loganin. In the destabilization of the medial meniscus (DMM)-induced mouse 
      model, loganin administration attenuated cartilage degeneration by inhibiting 
      COX-2, MMP-3, and MMP-13. Transverse micro-CT images revealed that loganin 
      reduced DMM-induced osteophyte formation. These results indicate that loganin has 
      protective effects in DMM-induced mice.
FAU - Park, Eunkuk
AU  - Park E
AUID- ORCID: 0000-0002-1928-5531
AD  - Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, 
      Korea.
AD  - Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 
      Suwon 16499, Korea.
FAU - Lee, Chang Gun
AU  - Lee CG
AUID- ORCID: 0000-0002-2031-0802
AD  - Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, 
      Korea.
AD  - Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 
      Suwon 16499, Korea.
FAU - Yun, Seung Hee
AU  - Yun SH
AD  - Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, 
      Korea.
AD  - Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 
      Suwon 16499, Korea.
FAU - Hwang, Seokjin
AU  - Hwang S
AD  - Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, 
      Korea.
AD  - Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 
      Suwon 16499, Korea.
FAU - Jeon, Hyoju
AU  - Jeon H
AD  - Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, 
      Korea.
AD  - Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 
      Suwon 16499, Korea.
FAU - Kim, Jeonghyun
AU  - Kim J
AD  - Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, 
      Korea.
AD  - Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 
      Suwon 16499, Korea.
FAU - Yeo, Subin
AU  - Yeo S
AD  - Nine B Co. Ltd., Daejeon 34121, Korea.
FAU - Jeong, Hyesoo
AU  - Jeong H
AD  - Nine B Co. Ltd., Daejeon 34121, Korea.
FAU - Yun, Seong-Hoon
AU  - Yun SH
AD  - Nine B Co. Ltd., Daejeon 34121, Korea.
FAU - Jeong, Seon-Yong
AU  - Jeong SY
AUID- ORCID: 0000-0002-0625-3530
AD  - Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, 
      Korea.
AD  - Department of Biomedical Sciences, Ajou University Graduate School of Medicine, 
      Suwon 16499, Korea.
AD  - Nine B Co. Ltd., Daejeon 34121, Korea.
LA  - eng
GR  - S2910765/Technology development Program of the Ministry of SMEs and Startups/
GR  - S2622262/Technology development Program of the Ministry of SMEs and Startups/
GR  - 2020R1I1A1A01072353/National Research Foundation of Korea (NRF) grant funded by 
      the Korean government/
PT  - Journal Article
DEP - 20210208
PL  - Switzerland
TA  - Pharmaceuticals (Basel)
JT  - Pharmaceuticals (Basel, Switzerland)
JID - 101238453
PMC - PMC7914920
OTO - NOTNLM
OT  - Cornus officinalis
OT  - anti-inflammatory effect
OT  - arthritis
OT  - destabilization of the medial meniscus
OT  - loganin
COIS- The authors declare no conflict of interest.
EDAT- 2021/02/12 06:00
MHDA- 2021/02/12 06:01
PMCR- 2021/02/08
CRDT- 2021/02/11 01:00
PHST- 2021/01/06 00:00 [received]
PHST- 2021/01/29 00:00 [revised]
PHST- 2021/02/04 00:00 [accepted]
PHST- 2021/02/11 01:00 [entrez]
PHST- 2021/02/12 06:00 [pubmed]
PHST- 2021/02/12 06:01 [medline]
PHST- 2021/02/08 00:00 [pmc-release]
AID - ph14020135 [pii]
AID - pharmaceuticals-14-00135 [pii]
AID - 10.3390/ph14020135 [doi]
PST - epublish
SO  - Pharmaceuticals (Basel). 2021 Feb 8;14(2):135. doi: 10.3390/ph14020135.