PMID- 33567540
OWN - NLM
STAT- MEDLINE
DCOM- 20210412
LR  - 20231110
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 4
DP  - 2021 Feb 8
TI  - Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the 
      Missing Link?
LID - 10.3390/ijms22041690 [doi]
LID - 1690
AB  - The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) 
      remains unclear. HHCy is associated with inflammation and atherosclerosis, and it 
      is an independent risk factor for CVD, stroke and myocardial infarction. However, 
      homocysteine (HCy)-lowering therapy does not affect the inflammatory state of CVD 
      patients, and it has little influence on cardiovascular risk. The HCy degradation 
      product hydrogen sulfide (H(2)S) is a cardioprotector. Previous research proposed 
      a positive role of H(2)S in the cardiovascular system, and we discuss some recent 
      data suggesting that HHCy worsens CVD by increasing the production of H(2)S, 
      which decreases the expression of adenosine A(2A) receptors on the surface of 
      immune and cardiovascular cells to cause inflammation and ischemia, respectively.
FAU - Paganelli, Franck
AU  - Paganelli F
AD  - C2VN, INSERM, INRAE, Aix-Marseille University, F-13005 Marseille, France.
AD  - Department of Cardiology, North Hospital, F-13015 Marseille, France.
FAU - Mottola, Giovanna
AU  - Mottola G
AUID- ORCID: 0000-0002-7541-0472
AD  - C2VN, INSERM, INRAE, Aix-Marseille University, F-13005 Marseille, France.
AD  - Laboratory of Biochemistry, Timone Hospital, F-13005 Marseille, France.
FAU - Fromonot, Julien
AU  - Fromonot J
AD  - C2VN, INSERM, INRAE, Aix-Marseille University, F-13005 Marseille, France.
AD  - Laboratory of Biochemistry, Timone Hospital, F-13005 Marseille, France.
FAU - Marlinge, Marion
AU  - Marlinge M
AD  - C2VN, INSERM, INRAE, Aix-Marseille University, F-13005 Marseille, France.
AD  - Laboratory of Biochemistry, Timone Hospital, F-13005 Marseille, France.
FAU - Deharo, Pierre
AU  - Deharo P
AD  - C2VN, INSERM, INRAE, Aix-Marseille University, F-13005 Marseille, France.
AD  - Department of Cardiology, Timone Hospital, F-13005 Marseille, France.
FAU - Guieu, Regis
AU  - Guieu R
AUID- ORCID: 0000-0002-3824-0814
AD  - C2VN, INSERM, INRAE, Aix-Marseille University, F-13005 Marseille, France.
AD  - Laboratory of Biochemistry, Timone Hospital, F-13005 Marseille, France.
FAU - Ruf, Jean
AU  - Ruf J
AUID- ORCID: 0000-0003-4300-8048
AD  - C2VN, INSERM, INRAE, Aix-Marseille University, F-13005 Marseille, France.
LA  - eng
GR  - None/ARCHANTEC/
PT  - Journal Article
PT  - Review
DEP - 20210208
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Receptor, Adenosine A2A)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - YY9FVM7NSN (Hydrogen Sulfide)
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/*etiology/metabolism/pathology
MH  - Homocysteine/*metabolism
MH  - Humans
MH  - Hydrogen Sulfide/*metabolism
MH  - Hyperhomocysteinemia/*complications/metabolism
MH  - Receptor, Adenosine A2A/*metabolism
PMC - PMC7914561
OTO - NOTNLM
OT  - adenosine
OT  - adenosine A2A receptors
OT  - cardiovascular disease
OT  - hydrogen sulfide
OT  - hyperhomocysteinemia
COIS- The authors declare no conflict of interest.
EDAT- 2021/02/12 06:00
MHDA- 2021/04/13 06:00
PMCR- 2021/02/08
CRDT- 2021/02/11 01:00
PHST- 2021/01/14 00:00 [received]
PHST- 2021/01/30 00:00 [revised]
PHST- 2021/02/04 00:00 [accepted]
PHST- 2021/02/11 01:00 [entrez]
PHST- 2021/02/12 06:00 [pubmed]
PHST- 2021/04/13 06:00 [medline]
PHST- 2021/02/08 00:00 [pmc-release]
AID - ijms22041690 [pii]
AID - ijms-22-01690 [pii]
AID - 10.3390/ijms22041690 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Feb 8;22(4):1690. doi: 10.3390/ijms22041690.