PMID- 33569417
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220420
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 9
IP  - 2
DP  - 2021 Jan
TI  - Gender differences of relationship between serum lipid indices and type 2 
      diabetes mellitus: a cross-sectional survey in Chinese elderly adults.
PG  - 115
LID - 10.21037/atm-20-2478 [doi]
LID - 115
AB  - BACKGROUND: To investigate the gender differences of the relationships between 
      clinical serum lipid indices and type 2 diabetes mellitus (T2DM) in Chinese 
      elderly adults. METHODS: Between 2014 and 2016, participants selected from three 
      communities in an urban district of Shanghai were measured for serum lipid 
      indices of low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein 
      cholesterol (HDL-c), total cholesterol (TC), and triglyceride (TG). Age and 
      multivariate adjusted logistic regression models were utilized to estimate the 
      odds ratios (ORs) and 95% confidence intervals (CIs) of serum lipid indices on 
      T2DM prevalence. RESULTS: In total, 4,023 male and 3,862 female participants were 
      included in this study, with the T2DM prevalence proportions of 13.03% and 
      11.73%, respectively. In association analysis, the serum levels of LDL-c, HDL-c, 
      TC were significant between non-T2DM individuals and T2DM patients in men, but 
      the HDL-c and TG in women. LDL-c/HDL-c, TG/HDL-c, and TC/HDL-c ratios were 
      associated with the T2DM prevalence only in women. In the multivariate analysis, 
      a higher serum LDL-c level was positively associated with a reduced risk of T2DM 
      prevalence in men with OR (95% CI) of 0.57 (0.39-0.85) (P=0.006). Higher ratios 
      of LDL-c/HDL-c, TG/HDL-c, and TC/HDL-c were all more likely associated with the 
      decreased risks of T2DM prevalence with the ORs ranging from 0.45 to 0.62 in men 
      (all P<0.05), but not in women. CONCLUSIONS: High LDL-c concentration was 
      significantly associated with a lower T2DM prevalence in men. A gender difference 
      of the associations between the lipid ratios and T2DM prevalence was observed for 
      LDL-c/HDL-c and TC/HDL-c ratios, which might be validated in female T2DM 
      prevalence in the future.
CI  - 2021 Annals of Translational Medicine. All rights reserved.
FAU - Ji, Xiao-Wei
AU  - Ji XW
AD  - School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
AD  - State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, 
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
FAU - Feng, Guo-Shan
AU  - Feng GS
AD  - School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
AD  - State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, 
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
FAU - Li, Hong-Lan
AU  - Li HL
AD  - State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, 
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
FAU - Fang, Jie
AU  - Fang J
AD  - State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, 
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
FAU - Wang, Jing
AU  - Wang J
AD  - State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, 
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
FAU - Shen, Qiu-Ming
AU  - Shen QM
AD  - State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, 
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
FAU - Han, Li-Hua
AU  - Han LH
AD  - State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, 
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
FAU - Liu, Da-Ke
AU  - Liu DK
AD  - State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, 
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
FAU - Xiang, Yong-Bing
AU  - Xiang YB
AD  - School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
AD  - State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, 
      Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC7867915
OTO - NOTNLM
OT  - Serum lipid indices
OT  - cross-sectional study
OT  - gender difference
OT  - type 2 diabetes mellitus (T2DM)
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/atm-20-2478). Dr. YBX reports 
      grants from Research Grant from the State Key Laboratory of Oncogenes and Related 
      Genes (#91-1708), during the conduct of the study. The other authors have no 
      conflicts of interest to declare.
EDAT- 2021/02/12 06:00
MHDA- 2021/02/12 06:01
PMCR- 2021/01/01
CRDT- 2021/02/11 05:55
PHST- 2021/02/11 05:55 [entrez]
PHST- 2021/02/12 06:00 [pubmed]
PHST- 2021/02/12 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - atm-09-02-115 [pii]
AID - 10.21037/atm-20-2478 [doi]
PST - ppublish
SO  - Ann Transl Med. 2021 Jan;9(2):115. doi: 10.21037/atm-20-2478.