PMID- 33569992
OWN - NLM
STAT- MEDLINE
DCOM- 20210719
LR  - 20210719
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 62
IP  - 7
DP  - 2021 Jul
TI  - Outcomes in chronic lymphocytic leukemia patients on novel agents in the US 
      Veterans Health Administration System.
PG  - 1664-1673
LID - 10.1080/10428194.2021.1876863 [doi]
AB  - The US veteran population has a high proportion of chronic lymphocytic leukemia 
      (CLL) risk factors. Using the Veterans Health Administration (VHA) population, we 
      conducted a retrospective chart review of 1205 CLL patients who initiated 
      treatment with a novel oral agent. For 1L ibrutinib, 33% (n = 107) discontinued 
      therapy during the study, of which 64% discontinued due to adverse events (AEs). 
      For relapsed/refractory (R/R) ibrutinib, 35% (n = 262) discontinued therapy, of 
      which 63% discontinued due to AEs. For R/R venetoclax, 31% (n = 27) discontinued 
      therapy, of which 41% were due to AEs. For idelalisib, 84% (n = 41) discontinued 
      therapy, of which 54% were due to AEs. This real-world study suggests that AEs 
      play an important role in dose reductions and discontinuations; however, 
      physician inexperience in using these drugs when they were first introduced could 
      be part of what is leading to these negative outcomes.
FAU - Frei, Christopher R
AU  - Frei CR
AUID- ORCID: 0000-0002-0692-4787
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
AD  - College of Pharmacy, The University of Texas at Austin, San Antonio, TX, USA.
AD  - Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, 
      USA.
FAU - Le, Hannah
AU  - Le H
AD  - AstraZeneca US Medical Affairs, Gaithersburg, MD, USA.
FAU - McHugh, Daniel
AU  - McHugh D
AD  - AstraZeneca US Medical Affairs, Gaithersburg, MD, USA.
FAU - Ryan, Kellie
AU  - Ryan K
AD  - AstraZeneca US Medical Affairs, Gaithersburg, MD, USA.
FAU - Jones, Xavier
AU  - Jones X
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
AD  - College of Pharmacy, The University of Texas at Austin, San Antonio, TX, USA.
AD  - Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, 
      USA.
FAU - Galley, Samantha
AU  - Galley S
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
FAU - Franklin, Kathleen
AU  - Franklin K
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
FAU - Baus, Courtney J
AU  - Baus CJ
AD  - College of Pharmacy, The University of Texas at Austin, San Antonio, TX, USA.
AD  - Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, 
      USA.
FAU - Tavera, Juan
AU  - Tavera J
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
FAU - Janania-Martinez, Michelle
AU  - Janania-Martinez M
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
FAU - Gregorio, David
AU  - Gregorio D
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
FAU - Ananth, Snegha
AU  - Ananth S
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
FAU - Uribe, Ricardo
AU  - Uribe R
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
FAU - Surapaneni, Prathibha
AU  - Surapaneni P
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
FAU - Espinoza-Gutarra, Manuel
AU  - Espinoza-Gutarra M
AUID- ORCID: 0000-0002-7906-8782
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
FAU - Song, Michael M
AU  - Song MM
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
FAU - Teng, Chengwen
AU  - Teng C
AUID- ORCID: 0000-0001-9239-2125
AD  - Department of Clinical Pharmacy and Outcomes Sciences, College of Pharmacy, The 
      University of South Carolina, Columbia, SC, USA.
FAU - Obodozie-Ofoegbu, Obiageri O
AU  - Obodozie-Ofoegbu OO
AD  - College of Pharmacy, The University of Texas at Austin, San Antonio, TX, USA.
AD  - Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, 
      USA.
FAU - Nooruddin, Zohra
AU  - Nooruddin Z
AUID- ORCID: 0000-0003-4659-4310
AD  - South Texas Veterans Health Care System, San Antonio, TX, USA.
AD  - Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, 
      USA.
LA  - eng
GR  - UL1 TR002645/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210211
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Pyrazoles)
RN  - 0 (Pyrimidines)
SB  - IM
MH  - Humans
MH  - *Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy/epidemiology
MH  - Pyrazoles/adverse effects
MH  - Pyrimidines/adverse effects
MH  - Retrospective Studies
MH  - Veterans Health
OTO - NOTNLM
OT  - Chronic lymphocytic leukemia
OT  - adverse events
OT  - chart review
OT  - discontinuation
OT  - dose reduction
OT  - novel agents
EDAT- 2021/02/12 06:00
MHDA- 2021/07/20 06:00
CRDT- 2021/02/11 08:38
PHST- 2021/02/12 06:00 [pubmed]
PHST- 2021/07/20 06:00 [medline]
PHST- 2021/02/11 08:38 [entrez]
AID - 10.1080/10428194.2021.1876863 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2021 Jul;62(7):1664-1673. doi: 10.1080/10428194.2021.1876863. Epub 
      2021 Feb 11.