PMID- 33570478
OWN - NLM
STAT- MEDLINE
DCOM- 20220201
LR  - 20220201
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 19
IP  - 5
DP  - 2021 Jun
TI  - A High-Fat Diet Induces Lower Systemic Inflammation than a High-Carbohydrate Diet 
      in Mice.
PG  - 296-304
LID - 10.1089/met.2020.0116 [doi]
AB  - Background: We previously established that male Swiss mice (Mus musculus) 
      receiving a high-fat diet (HFD) during 8 weeks exhibit similar caloric ingestion 
      and body weight (grams) compared with mice fed a high-carbohydrate diet (HCD). 
      HFD mice exhibit a lower inflammatory state than an HCD in the liver, skeletal 
      muscle, and brain. In addition, we demonstrated that HFD and HCD modulated fatty 
      acids (FA) composition in these tissues. In this study, our objective was to 
      compare HFD mice and HCD mice in terms of systemic inflammation. Methods: 
      Saturated FA (SFA), monounsaturated FA, omega-6 polyunsaturated FA (n-6 PUFA), 
      and n-3 PUFA were evaluated at the time points 0, 1, 7, 14, 28, and 56 days after 
      starting the administration of the diets. We investigated n-6 PUFA:n-3 PUFA, 
      SFA:n-3 PUFA, palmitic acid:alpha-linolenic acid (ALA), and myristic 
      acid:docosahexaenoic acid (DHA) ratios as potential serum biomarkers of systemic 
      inflammation. We also measured the serum levels of basic fibroblast growth 
      factor, granulocyte-macrophage colony-stimulating factor (GM-CSF), inducible 
      protein 10 (IP-10), interferon gamma (IFN-gamma), interleukin (IL)-1alpha, IL-1beta, IL-2, 
      IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, macrophage inflammatory protein-1alpha 
      (MIP-1-alpha), monocyte chemotactic protein 1 (MCP-1), monokine induced by IFN-gamma 
      (MIG), and tumor necrosis factor alpha (TNF-alpha). Results: The HFD group had lower 
      (P < 0.05) n-6 PUFA:n-3 PUFA, palmitic acid:ALA, myristic acid:DHA ratios, and 
      lower plasma levels of proinflammatory cytokines (IFN-gamma, MIG, GM-CSF, and IL-6). 
      Conclusion: The HFD mice showed lower systemic inflammation compared with a 
      caloric ingestion-body weight-matched control HCD mice.
FAU - de Almeida-Souza, Camila B
AU  - de Almeida-Souza CB
AD  - Post-Graduate Program in Pharmaceutical Sciences, State University of Maringa, 
      Maringa, Brazil.
FAU - Antunes, Marina M
AU  - Antunes MM
AD  - Post-Graduate Program in Pharmaceutical Sciences, State University of Maringa, 
      Maringa, Brazil.
FAU - Carbonera, Fabiana
AU  - Carbonera F
AD  - Department of Chemistry, State University of Maringa, Maringa, Brazil.
FAU - Godoy, Guilherme
AU  - Godoy G
AD  - Post-Graduate Program in Pharmaceutical Sciences, State University of Maringa, 
      Maringa, Brazil.
FAU - da Silva, Maria A R C P
AU  - da Silva MARCP
AD  - Department of Pharmacology and Therapeutics, State University of Maringa, 
      Maringa, Brazil.
FAU - Masi, Laureane N
AU  - Masi LN
AD  - Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul 
      University, Sao Paulo, Brazil.
FAU - Visentainer, Jesui V
AU  - Visentainer JV
AD  - Department of Chemistry, State University of Maringa, Maringa, Brazil.
FAU - Curi, Rui
AU  - Curi R
AD  - Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul 
      University, Sao Paulo, Brazil.
FAU - Bazotte, Roberto B
AU  - Bazotte RB
AD  - Post-Graduate Program in Pharmaceutical Sciences, State University of Maringa, 
      Maringa, Brazil.
AD  - Department of Pharmacology and Therapeutics, State University of Maringa, 
      Maringa, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210210
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0 (Dietary Carbohydrates)
SB  - IM
MH  - Animals
MH  - *Diet, High-Fat/adverse effects
MH  - *Dietary Carbohydrates/adverse effects
MH  - *Inflammation/epidemiology
MH  - Male
MH  - Mice
OTO - NOTNLM
OT  - macronutrients
OT  - monounsaturated fatty acids
OT  - n-3 PUFA
OT  - n-6 PUFA
OT  - polyunsaturated fatty acids
OT  - saturated fatty acids
OT  - serum cytokines
EDAT- 2021/02/12 06:00
MHDA- 2022/02/02 06:00
CRDT- 2021/02/11 12:09
PHST- 2021/02/12 06:00 [pubmed]
PHST- 2022/02/02 06:00 [medline]
PHST- 2021/02/11 12:09 [entrez]
AID - 10.1089/met.2020.0116 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2021 Jun;19(5):296-304. doi: 10.1089/met.2020.0116. 
      Epub 2021 Feb 10.