PMID- 33573005
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210304
IS  - 2079-4991 (Print)
IS  - 2079-4991 (Electronic)
IS  - 2079-4991 (Linking)
VI  - 11
IP  - 2
DP  - 2021 Jan 29
TI  - Real-Time Tracking of Highly Luminescent Mesoporous Silica Particles Modified 
      with Europium beta-Diketone Chelates in Living Cells.
LID - 10.3390/nano11020343 [doi]
LID - 343
AB  - Highly luminescent europium complexes modified mesoporous silica particles (MSP) 
      were synthesized as an imaging probes for both in-vitro diagnostic and in-vivo 
      cellular tracking agents. Europium beta-diketone chelates 
      (4,4,4-trifluoro-l-(2-thienyl)-l,3-butanedione) trioctylphosphine europium (III) 
      (Eu(TTA)(3)(P(Oct)(3))(3)) were incorporated inside the nanocavities that existed 
      in hierarchical MSP (Eu@MSP). The MSP and Eu@MSP on mouse bone marrow-derived 
      macrophages (BMDMs) did not show any toxic effect. The MSP and Eu@MSP in the 
      BMDMs were found at cytoplasm without any degradation and immunogenicity. 
      However, both pro- and anti-inflammatory cytokines of macrophages were 
      significantly increased when lipopolysaccharide and a high concentration (100 
      mug/mL) of MSP and Eu@MSP were treated simultaneously.
FAU - Kim, Jong-Seok
AU  - Kim JS
AUID- ORCID: 0000-0002-0998-5569
AD  - Myunggok Medical Research Institute, College of Medicine, Konyang University, 
      Daejeon 35365, Korea.
FAU - Lee, Sung Ki
AU  - Lee SK
AD  - Department of Obstetrics and Gynecology, Konyang University Hospital, Daejeon 
      35365, Korea.
FAU - Doh, Hansol
AU  - Doh H
AD  - Department of Food Science and Technology, University of California-Davis, Davis, 
      CA 95616, USA.
FAU - Kim, Myeong Yun
AU  - Kim MY
AD  - Department of Anatomy, College of Medicine, Konyang University Hospital, Daejeon 
      35365, Korea.
FAU - Kim, Do Kyung
AU  - Kim DK
AUID- ORCID: 0000-0001-6655-7061
AD  - Department of Anatomy, College of Medicine, Konyang University Hospital, Daejeon 
      35365, Korea.
LA  - eng
GR  - 2017R1A2B4005167/National Research Foundation of Korea/
GR  - 2018R1C1B6007421/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20210129
PL  - Switzerland
TA  - Nanomaterials (Basel)
JT  - Nanomaterials (Basel, Switzerland)
JID - 101610216
PMC - PMC7919370
OTO - NOTNLM
OT  - beta-diketone
OT  - europium complex
OT  - inflammation
OT  - live cell image
OT  - mesoporous silica
COIS- The authors declare that they have no known conflict of interest associated with 
      this publication and there has been no competing financial interest for this work 
      that could have influenced its outcome.
EDAT- 2021/02/13 06:00
MHDA- 2021/02/13 06:01
PMCR- 2021/01/29
CRDT- 2021/02/12 01:03
PHST- 2021/01/06 00:00 [received]
PHST- 2021/01/24 00:00 [revised]
PHST- 2021/01/25 00:00 [accepted]
PHST- 2021/02/12 01:03 [entrez]
PHST- 2021/02/13 06:00 [pubmed]
PHST- 2021/02/13 06:01 [medline]
PHST- 2021/01/29 00:00 [pmc-release]
AID - nano11020343 [pii]
AID - nanomaterials-11-00343 [pii]
AID - 10.3390/nano11020343 [doi]
PST - epublish
SO  - Nanomaterials (Basel). 2021 Jan 29;11(2):343. doi: 10.3390/nano11020343.