PMID- 33573820
OWN - NLM
STAT- MEDLINE
DCOM- 20210706
LR  - 20230328
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 53
IP  - 4
DP  - 2021 May
TI  - Coronavirus Disease 2019 in Kidney Transplant Recipients: Single-Center 
      Experience and Case-Control Study.
PG  - 1187-1193
LID - S0041-1345(21)00003-8 [pii]
LID - 10.1016/j.transproceed.2021.01.002 [doi]
AB  - BACKGROUND: Kidney transplant recipients (KTR) are considered high-risk for 
      morbidity and mortality from coronavirus disease 2019 (COVID-19). However, some 
      studies did not show worse outcomes compared to non-transplant patients and there 
      is little data about immunosuppressant drug levels and secondary infections in 
      KTR with COVID-19. Herein, we describe our single-center experience with COVID-19 
      in KTR. METHODS: We captured KTR diagnosed with COVID-19 between March 1, 2020 
      and May 18, 2020. After exclusion of KTR on hemodialysis and off 
      immunosuppression, we compared the clinical course of COVID-19 between 
      hospitalized KTR and non-transplant patients, matched by age and sex (controls). 
      RESULTS: Eleven KTR were hospitalized and matched with 44 controls. One KTR and 4 
      controls died (case fatality rate: 9.1%). There were no significant differences 
      in length of stay or clinical outcomes between KTR and controls. Tacrolimus or 
      sirolimus levels were >10 ng/mL in 6 out of 9 KTR (67%). Bacterial infections 
      were more frequent in KTR (36.3%), compared with controls (6.8%, P = .02). 
      CONCLUSIONS: In our small case series, unlike earlier reports from the pandemic 
      epicenters, the clinical outcomes of KTR with COVID-19 were comparable to those 
      of non-transplant patients. Calcineurin or mammalian target of rapamycin 
      inhibitor (mTOR) levels were high. Bacterial infections were more common in KTR, 
      compared with controls.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Hardesty, Anna
AU  - Hardesty A
AD  - Department of Internal Medicine, Residency, Warren Alpert Medical School of Brown 
      University, Providence, Rhode Island. Electronic address: 
      ahardesty1@lifespan.org.
FAU - Pandita, Aakriti
AU  - Pandita A
AD  - Division of Infectious Diseases, Warren Alpert Medical School of Brown 
      University, Providence, Rhode Island.
FAU - Vieira, Kendra
AU  - Vieira K
AD  - Division of Infectious Diseases, Warren Alpert Medical School of Brown 
      University, Providence, Rhode Island.
FAU - Rogers, Ralph
AU  - Rogers R
AD  - Division of Infectious Diseases, Warren Alpert Medical School of Brown 
      University, Providence, Rhode Island.
FAU - Merhi, Basma
AU  - Merhi B
AD  - Division of Nephrology, Warren Alpert Medical School of Brown University, 
      Providence, Rhode Island.
FAU - Osband, Adena J
AU  - Osband AJ
AD  - Department of Surgery (Transplantation), Warren Alpert Medical School of Brown 
      University, Providence, Rhode Island.
FAU - Aridi, Jad
AU  - Aridi J
AD  - Division of Infectious Diseases, Warren Alpert Medical School of Brown 
      University, Providence, Rhode Island.
FAU - Shi, Yiyun
AU  - Shi Y
AD  - Department of Internal Medicine, Residency, Warren Alpert Medical School of Brown 
      University, Providence, Rhode Island.
FAU - Bayliss, George
AU  - Bayliss G
AD  - Division of Nephrology, Warren Alpert Medical School of Brown University, 
      Providence, Rhode Island.
FAU - Cosgrove, Christopher
AU  - Cosgrove C
AD  - Division of Nephrology, Warren Alpert Medical School of Brown University, 
      Providence, Rhode Island.
FAU - Gohh, Reginald
AU  - Gohh R
AD  - Division of Nephrology, Warren Alpert Medical School of Brown University, 
      Providence, Rhode Island.
FAU - Morrissey, Paul
AU  - Morrissey P
AD  - Department of Surgery (Transplantation), Warren Alpert Medical School of Brown 
      University, Providence, Rhode Island.
FAU - Beckwith, Curt G
AU  - Beckwith CG
AD  - Division of Infectious Diseases, Warren Alpert Medical School of Brown 
      University, Providence, Rhode Island.
FAU - Farmakiotis, Dimitrios
AU  - Farmakiotis D
AD  - Division of Infectious Diseases, Warren Alpert Medical School of Brown 
      University, Providence, Rhode Island. Electronic address: 
      dimitrios.farmakiotis@lifespan.org.
LA  - eng
PT  - Journal Article
DEP - 20210113
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Antiviral Agents)
RN  - 0 (Immunosuppressive Agents)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antiviral Agents/therapeutic use
MH  - COVID-19/complications/*diagnosis/virology
MH  - Case-Control Studies
MH  - Female
MH  - Graft Rejection/prevention & control
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Kidney Failure, Chronic/complications/therapy
MH  - *Kidney Transplantation
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Pandemics
MH  - SARS-CoV-2/isolation & purification
MH  - Sirolimus/therapeutic use
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Tacrolimus/therapeutic use
MH  - Treatment Outcome
MH  - COVID-19 Drug Treatment
PMC - PMC7836220
EDAT- 2021/02/13 06:00
MHDA- 2021/07/07 06:00
PMCR- 2021/01/13
CRDT- 2021/02/12 05:43
PHST- 2021/01/01 00:00 [received]
PHST- 2021/01/07 00:00 [accepted]
PHST- 2021/02/13 06:00 [pubmed]
PHST- 2021/07/07 06:00 [medline]
PHST- 2021/02/12 05:43 [entrez]
PHST- 2021/01/13 00:00 [pmc-release]
AID - S0041-1345(21)00003-8 [pii]
AID - 10.1016/j.transproceed.2021.01.002 [doi]
PST - ppublish
SO  - Transplant Proc. 2021 May;53(4):1187-1193. doi: 
      10.1016/j.transproceed.2021.01.002. Epub 2021 Jan 13.