PMID- 33575699
OWN - NLM
STAT- MEDLINE
DCOM- 20210217
LR  - 20220218
IS  - 2260-1341 (Print)
IS  - 2273-4309 (Electronic)
IS  - 2260-1341 (Linking)
VI  - 10
IP  - 2
DP  - 2021
TI  - The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: 
      Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort).
PG  - 110-120
LID - 10.14283/jfa.2020.38 [doi]
AB  - BACKGROUND: The Geroscience field focuses on the core biological mechanisms of 
      aging, which are involved in the onset of age-related diseases, as well as 
      declines in intrinsic capacity (IC) (body functions) leading to dependency. A 
      better understanding on how to measure the true age of an individual or 
      biological aging is an essential step that may lead to the definition of putative 
      markers capable of predicting healthy aging. OBJECTIVES: The main objective of 
      the INStitute for Prevention healthy agIng and medicine Rejuvenative (INSPIRE) 
      Platform initiative is to build a program for Geroscience and healthy aging 
      research going from animal models to humans and the health care system. The 
      specific aim of the INSPIRE human translational cohort (INSPIRE-T cohort) is to 
      gather clinical, digital and imaging data, and perform relevant and extensive 
      biobanking to allow basic and translational research on humans. METHODS: The 
      INSPIRE-T cohort consists in a population study comprising 1000 individuals in 
      Toulouse and surrounding areas (France) of different ages (20 years or over - no 
      upper limit for age) and functional capacity levels (from robustness to frailty, 
      and even dependency) with follow-up over 10 years. Diversified data are collected 
      annually in research facilities or at home according to standardized procedures. 
      Between two annual visits, IC domains are monitored every 4-month by using the 
      ICOPE Monitor app developed in collaboration with WHO. Once IC decline is 
      confirmed, participants will have a clinical assessment and blood sampling to 
      investigate markers of aging at the time IC declines are detected. Biospecimens 
      include blood, urine, saliva, and dental plaque that are collected from all 
      subjects at baseline and then, annually. Nasopharyngeal swabs and cutaneous 
      surface samples are collected in a large subgroup of subjects every two years. 
      Feces, hair bulb and skin biopsy are collected optionally at the baseline visit 
      and will be performed again during the longitudinal follow up. EXPECTED RESULTS: 
      Recruitment started on October 2019 and is expected to last for two years. 
      Bio-resources collected and explored in the INSPIRE-T cohort will be available 
      for academic and industry partners aiming to identify robust (set of) markers of 
      aging, age-related diseases and IC evolution that could be pharmacologically or 
      non-pharmacologically targetable. The INSPIRE-T will also aim to develop an 
      integrative approach to explore the use of innovative technologies and a new, 
      function and person-centered health care pathway that will promote a healthy 
      aging.
FAU - Guyonnet, S
AU  - Guyonnet S
AD  - Sophie Guyonnet, Inserm UMR 1027, Toulouse, France; University of Toulouse III, 
      Toulouse, France; Gerontopole, Department of Geriatrics, CHU Toulouse, Toulouse, 
      France, guyonnet.s@chu-toulouse.fr.
FAU - Rolland, Y
AU  - Rolland Y
FAU - Takeda, C
AU  - Takeda C
FAU - Ousset, P-J
AU  - Ousset PJ
FAU - Ader, I
AU  - Ader I
FAU - Davezac, N
AU  - Davezac N
FAU - Dray, C
AU  - Dray C
FAU - Fazilleau, N
AU  - Fazilleau N
FAU - Gourdy, P
AU  - Gourdy P
FAU - Liblau, R
AU  - Liblau R
FAU - Parini, A
AU  - Parini A
FAU - Payoux, P
AU  - Payoux P
FAU - Penicaud, L
AU  - Penicaud L
FAU - Rampon, C
AU  - Rampon C
FAU - Valet, P
AU  - Valet P
FAU - Vergnolle, N
AU  - Vergnolle N
FAU - Andrieu, S
AU  - Andrieu S
FAU - de Souto Barreto, P
AU  - de Souto Barreto P
FAU - Casteilla, L
AU  - Casteilla L
FAU - Vellas, B
AU  - Vellas B
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Frailty Aging
JT  - The Journal of frailty & aging
JID - 101604797
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Biological Specimen Banks
MH  - Cohort Studies
MH  - France
MH  - *Geriatrics
MH  - *Healthy Aging
MH  - Humans
MH  - Middle Aged
MH  - *Translational Research, Biomedical
PMC - PMC7352084
OTO - NOTNLM
OT  - Gerosciences
OT  - biological aging
OT  - biology of aging
OT  - integrated care
OT  - intrinsic capacity
OT  - translational research on aging
COIS- All authors of the paper "The INSPIRE research initiative: a program for 
      GeroScience and healthy aging research going from animal models to humans and the 
      healthcare system" declare no Conflicts of Interest related to this manuscript.
EDAT- 2021/02/13 06:00
MHDA- 2021/02/18 06:00
PMCR- 2020/07/10
CRDT- 2021/02/12 06:10
PHST- 2021/02/12 06:10 [entrez]
PHST- 2021/02/13 06:00 [pubmed]
PHST- 2021/02/18 06:00 [medline]
PHST- 2020/07/10 00:00 [pmc-release]
AID - 38 [pii]
AID - 10.14283/jfa.2020.38 [doi]
PST - ppublish
SO  - J Frailty Aging. 2021;10(2):110-120. doi: 10.14283/jfa.2020.38.