PMID- 33576133
OWN - NLM
STAT- MEDLINE
DCOM- 20220117
LR  - 20220117
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 99
IP  - 7
DP  - 2021 Nov
TI  - Functional and anatomical outcomes after successful repair of macula-off retinal 
      detachment: a 12-month follow-up of the DOREFA study.
PG  - e1190-e1197
LID - 10.1111/aos.14777 [doi]
AB  - PURPOSE: To report visual and anatomical outcomes and determine predictors of 
      good visual acuity (VA) recovery after macula-off rhegmatogenous retinal 
      detachment (RD). METHODS: Prospective multicentre study including 115 eyes from 
      115 patients successfully operated on for RD, with assessment of VA and 
      spectral-domain optical coherence tomography (SD-OCT) macular images at 1, 3, 6 
      and 12 months after surgery. RESULTS: Over the follow-up period, VA significantly 
      improved from median [IQR] 62 [46; 72] ETDRS letters at 1 month to 75 [67; 80] 
      ETDRS letters at 12 months (p < 0.001) with a concomitant decreased number of 
      eyes with any SD-OCT lesions (p < 0.001). The presence of subretinal fluid (SRF) 
      significantly decreased (p < 0.001), as did the number of photoreceptor (PR) 
      layer lesions (p = 0.04). At 12 months, lesions in the PR layer and poor VA 
      recovery were significantly associated with a longer time to surgery (p = 0.007 
      and p < 0.001, respectively). The rate of patients without PR lesions increased 
      from 40.9% at 1 month to 60.0% at 6 months and 73.9% at 12 months (p < 0.001). 
      The incidence of epiretinal membrane (ERM) significantly increased (p < 0.001), 
      while cystoid macular oedema (CME) remained stable over time. Visual acuity (VA) 
      at 3 months postoperatively was a good reflection of final VA recovery 
      (p < 0.001). CONCLUSION: Visual acuity (VA) improved in parallel with the 
      decreasing number of eyes with SD-OCT lesions after macula-off rhegmatogenous RD. 
      A long time to surgery was the only preoperative factor associated with poor VA 
      recovery after retinal detachment surgery.
CI  - (c) 2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Baudin, Florian
AU  - Baudin F
AUID- ORCID: 0000-0003-4976-9876
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
AD  - EA 7460 Pathophysiology and Epidemiology of Cerebro-Cardiovascular Diseases 
      (PEC2), University Hospital, Dijon, France.
FAU - Deschasse, Clemence
AU  - Deschasse C
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
FAU - Gabrielle, Pierre-Henry
AU  - Gabrielle PH
AUID- ORCID: 0000-0002-9688-4845
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
FAU - Berrod, Jean P
AU  - Berrod JP
AD  - Department of Ophthalmology, University Hospital, Nancy, France.
FAU - Le Mer, Yannick
AU  - Le Mer Y
AD  - Department of Ophthalmology, Fondation A. de Rothschild, Paris, France.
FAU - Arndt, Carl
AU  - Arndt C
AD  - Department of Ophthalmology, University Hospital, Reims, France.
FAU - Tadayoni, Ramin
AU  - Tadayoni R
AD  - Department of Ophthalmology, Lariboisiere Hospital, Paris, France.
FAU - Delyfer, Marie N
AU  - Delyfer MN
AUID- ORCID: 0000-0002-3127-8617
AD  - Department of Ophthalmology, University Hospital, Bordeaux, France.
FAU - Weber, Michel
AU  - Weber M
AD  - Department of Ophthalmology, University Hospital, Nantes, France.
FAU - Gaucher, David
AU  - Gaucher D
AD  - Department of Ophthalmology, University Hospital, Strasbourg, France.
AD  - Bacteriology institute, UR-7290, Strasbourg University, Strasbourg, France.
FAU - Saleh, Maher
AU  - Saleh M
AD  - Department of Ophthalmology, University Hospital, Besancon, France.
FAU - Chiquet, Christophe
AU  - Chiquet C
AUID- ORCID: 0000-0002-7601-4885
AD  - Department of Ophthalmology, University Hospital, Grenoble, France.
FAU - Creuzot-Garcher, Catherine
AU  - Creuzot-Garcher C
AUID- ORCID: 0000-0002-3587-4598
AD  - Department of Ophthalmology, University Hospital, Dijon, France.
AD  - Eye and Nutrition Research group, GSGA, UMR 1324 INRA, 6265 CNRS, Dijon, France.
LA  - eng
GR  - 2011-A00266-35/French Ministry of Health/
PT  - Journal Article
PT  - Multicenter Study
DEP - 20210211
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Macula Lutea/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Prospective Studies
MH  - Retinal Detachment/diagnosis/physiopathology/*surgery
MH  - Scleral Buckling/*methods
MH  - Time Factors
MH  - Tomography, Optical Coherence/methods
MH  - *Visual Acuity
MH  - Vitrectomy/*methods
OTO - NOTNLM
OT  - cystoid macular oedema
OT  - external limiting membrane
OT  - photoreceptor layer
OT  - rhegmatogenous retinal detachment
OT  - spectral-domain optical coherence tomography
OT  - subretinal fluid
OT  - vitreoretinal surgery
EDAT- 2021/02/13 06:00
MHDA- 2022/01/18 06:00
CRDT- 2021/02/12 06:15
PHST- 2020/12/11 00:00 [revised]
PHST- 2020/06/02 00:00 [received]
PHST- 2021/01/13 00:00 [accepted]
PHST- 2021/02/13 06:00 [pubmed]
PHST- 2022/01/18 06:00 [medline]
PHST- 2021/02/12 06:15 [entrez]
AID - 10.1111/aos.14777 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2021 Nov;99(7):e1190-e1197. doi: 10.1111/aos.14777. Epub 2021 
      Feb 11.