PMID- 33576501
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1096-9861 (Electronic)
IS  - 0021-9967 (Linking)
VI  - 529
IP  - 10
DP  - 2021 Jul 1
TI  - Conservation and dimorphism in androgen receptor distribution in Alston's singing 
      mouse (Scotinomys teguina).
PG  - 2539-2557
LID - 10.1002/cne.25108 [doi]
AB  - Because of their roles in courtship and intrasexual competition, sexual displays 
      are often sexually dimorphic, but we know little about the mechanisms that 
      produce such dimorphism. Among mammals, one example is the vocalization of 
      Alston's singing mouse (Scotinomys teguina), which consists of a series of 
      rapidly repeated, frequency-modulated notes. The rate and duration of songs is 
      sexually dimorphic and androgen responsive. To understand the neuronal mechanisms 
      underlying this sexual dimorphism, we map the sites of androgen sensitivity 
      throughout the brain, focusing analysis along a pathway that spans from limbic 
      structures to vocal motor regions. We find widespread expression of AR 
      immunoreactivity (AR-ir) throughout limbic structures important for social 
      behavior and vocalization, including the lateral septum, extended amygdala, 
      preoptic area and hypothalamus. We also find extensive AR staining along 
      previously documented vocal motor pathways, including the periaqueductal gray, 
      parabrachial nucleus, and nucleus ambiguus, the last of which innervates 
      intrinsic laryngeal muscles. Lastly, AR-ir is also evident in sensory areas such 
      as the medial geniculate, inferior, and superior colliculi. A quantitative 
      analysis revealed that males exhibited more AR-ir than females, a pattern that 
      was most pronounced in the hypothalamus. Despite the elaboration of vocalization 
      in singing mice, comparison with prior literature suggests that the broad pattern 
      of AR-ir may be conserved across a wide range of rodents. Together these data 
      identify brain nuclei well positioned to shape the sexually dimorphic 
      vocalization of S. teguina and suggest that such androgen modulation of 
      vocalization is evolutionary conserved among rodents.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Zheng, Da-Jiang
AU  - Zheng DJ
AUID- ORCID: 0000-0002-0081-8385
AD  - Department of Integrative Biology, The University of Texas at Austin, Austin, 
      Texas, USA.
FAU - Singh, Aditi
AU  - Singh A
AD  - Department of Integrative Biology, The University of Texas at Austin, Austin, 
      Texas, USA.
FAU - Phelps, Steven M
AU  - Phelps SM
AUID- ORCID: 0000-0002-1095-361X
AD  - Department of Integrative Biology, The University of Texas at Austin, Austin, 
      Texas, USA.
LA  - eng
GR  - R01 19-A0-00-1002501/NH/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20210212
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Receptors, Androgen)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Female
MH  - Male
MH  - Mice
MH  - Neural Pathways/*metabolism
MH  - Receptors, Androgen/*metabolism
MH  - *Sex Characteristics
MH  - Social Behavior
MH  - Vocalization, Animal/*physiology
OTO - NOTNLM
OT  - Alston's singing mice
OT  - RRID: AB_2313606
OT  - RRID: AB_310214
OT  - androgen receptor
OT  - dimorphism
OT  - hypothalamus
EDAT- 2021/02/13 06:00
MHDA- 2022/02/01 06:00
CRDT- 2021/02/12 08:40
PHST- 2020/12/25 00:00 [revised]
PHST- 2020/04/27 00:00 [received]
PHST- 2020/12/28 00:00 [accepted]
PHST- 2021/02/13 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/02/12 08:40 [entrez]
AID - 10.1002/cne.25108 [doi]
PST - ppublish
SO  - J Comp Neurol. 2021 Jul 1;529(10):2539-2557. doi: 10.1002/cne.25108. Epub 2021 
      Feb 12.