PMID- 33577998
OWN - NLM
STAT- MEDLINE
DCOM- 20210603
LR  - 20210603
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 749
DP  - 2021 Apr 1
TI  - The MCP-1 A-2518G polymorphism increases the risk of Alzheimer's disease: A 
      case-control study.
PG  - 135710
LID - S0304-3940(21)00088-4 [pii]
LID - 10.1016/j.neulet.2021.135710 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) is reported to associate with the 
      severity and development of Alzheimer's disease (AD). While a few studies have 
      examined the association between the MCP-1 A-2518 G polymorphism and AD risk, no 
      Chinese study has undertaken a study of this association. Therefore, a 
      case-control study with 212 AD cases and 268 controls was designed in Chinese 
      participants. Logistic regression analysis was utilized to probe the potential 
      link between AD susceptibility and the MCP-1 A-2518 G polymorphism. We observed 
      that the GG or GG + AG genotype was shown to elevate the risk of AD. Subgroup 
      analysis revealed this increased risk effect was also presented in males, 
      smokers, APOE epsilon4+ and those participants >/= 65 years old. Notably, cross-over 
      analysis found that this polymorphism interacted with smoking, contributing to 
      the increased risk of AD. In addition, we found that the serum MCP-1 levels of AD 
      patients were evidently higher than in controls. Furthermore, the MCP-1 A-2518 G 
      polymorphism was linked with the serum MCP-1 levels of AD patients, but not 
      controls. In conclusion, the MCP-1 A-2518 G polymorphism correlates with an 
      elevated risk of AD and increased MCP-1 serum levels. The interaction between the 
      MCP-1 A-2518 G polymorphism and smoking contributes to the increased risk for AD 
      in Chinese Han individuals.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Xu, Lifei
AU  - Xu L
AD  - Department of Encephalopathy, Zhenjiang Hospital Affiliated to Nanjing University 
      of Chinese Medicine (Zhenjiang Hospital of Traditional Chinese Medicine), 
      Zhenjiang, Jiangsu, China.
FAU - Dong, Qiuping
AU  - Dong Q
AD  - Department of Rehabilitation, Zhenjiang Hospital Affiliated to Nanjing University 
      of Chinese Medicine (Zhenjiang Hospital of Traditional Chinese Medicine), 
      Zhenjiang, Jiangsu, China.
FAU - Xu, Liben
AU  - Xu L
AD  - Department of Radiation Oncology, The Affiliated People's Hospital of Jiangsu 
      University, Zhenjiang, Jiangsu, China.
FAU - Zou, Wei
AU  - Zou W
AD  - Department of Acupuncture, Shaanxi Hospital of Traditional Chinese Medicine, 
      Shaanxi, China.
FAU - Li, Hui
AU  - Li H
AD  - Department of Acupuncture, Zhenjiang Hospital Affiliated to Nanjing University of 
      Chinese Medicine (Zhenjiang Hospital of Traditional Chinese Medicine), Zhenjiang, 
      Jiangsu, China. Electronic address: Lihui020284@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210209
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Case-control study
OT  - MCP-1 A-2518G polymorphism
EDAT- 2021/02/13 06:00
MHDA- 2021/06/04 06:00
CRDT- 2021/02/12 20:12
PHST- 2020/10/31 00:00 [received]
PHST- 2021/01/16 00:00 [revised]
PHST- 2021/02/02 00:00 [accepted]
PHST- 2021/02/13 06:00 [pubmed]
PHST- 2021/06/04 06:00 [medline]
PHST- 2021/02/12 20:12 [entrez]
AID - S0304-3940(21)00088-4 [pii]
AID - 10.1016/j.neulet.2021.135710 [doi]
PST - ppublish
SO  - Neurosci Lett. 2021 Apr 1;749:135710. doi: 10.1016/j.neulet.2021.135710. Epub 
      2021 Feb 9.