PMID- 33578584
OWN - NLM
STAT- MEDLINE
DCOM- 20210222
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 6
DP  - 2021 Feb 12
TI  - Higher levels of circulating ANGPTL2 are associated with macular edema in 
      patients with type 2 diabetes.
PG  - e24638
LID - 10.1097/MD.0000000000024638 [doi]
LID - e24638
AB  - Macular edema (ME) is an inflammatory disease characterized by increased 
      microvascular permeability. Here, we proposed that plasma angiopoietin-like 
      protein 2 (ANGPTL2) level may be related to the severity of ME patients with type 
      2 diabetes mellitus (T2DM). In this cross-sectional study, 172 T2DM patients were 
      recruited and divided into clinically significant macular edema (CSME), non-CSME 
      (nCSME), and control groups. Serum ANGPTL2 level was quantified by ELISA and best 
      corrected vision acuity (BCVA) was detected. After adjust age, sex, body mass 
      index (BMI), and duration of diabetes variables, ANGPTL2 performed statistics 
      difference among CSME-, nCSME-groups, and control group (4.46 [3.97, 4.96, 
      95%CI] ng/mL in CSME group, 3.80 [3.42, 4.18, 95%CI] ng/mL in nCSME-group, 3.33 
      [3.03, 3.63, 95%CI] ng/mL in control, P < .01). After adjustment of confounding 
      factors, high levels of circulating ANGPTL2 were related with the diagnosis of 
      ME, BCVA, and C reactive protein (CRP) through univariate regression analysis 
      (P < .05). Meanwhile, in the multiple regression model, ANGPTL2 took the mainly 
      effect proportion for the diagnosis of diabetic macular edema (DME), with a 
      LogWorth value 3.559 (P < .001). Our study suggested that elevated circulating 
      ANGPTL2 may be associated with the development of DME and the severity of visual 
      impairment in patients with type 2 diabetes.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Yin, Ruili
AU  - Yin R
AD  - Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, 
      Capital Medical University.
AD  - Beijing Key Laboratory of Diabetes Research and Care.
FAU - Zhang, Ning
AU  - Zhang N
AD  - Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, 
      Capital Medical University.
AD  - Beijing Key Laboratory of Diabetes Research and Care.
FAU - Zhang, Dawei
AU  - Zhang D
AD  - Department of Ophthalmology, Beijing Luhe Hospital Capital Medical University, 
      Beijing, 101149, China.
FAU - Zhao, Wenying
AU  - Zhao W
AD  - Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, 
      Capital Medical University.
FAU - Ke, Jing
AU  - Ke J
AD  - Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, 
      Capital Medical University.
FAU - Zhao, Dong
AU  - Zhao D
AUID- ORCID: 0000-0003-2914-5863
AD  - Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, 
      Capital Medical University.
LA  - eng
GR  - KJ2019CX014-25/Science and Technology Committee of Tongzhou District/
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (ANGPTL2 protein, human)
RN  - 0 (Angiopoietin-Like Protein 2)
RN  - 0 (Angiopoietin-like Proteins)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Angiopoietin-Like Protein 2
MH  - Angiopoietin-like Proteins/*blood
MH  - Biomarkers/blood
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Humans
MH  - Macular Edema/blood/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Tomography, Optical Coherence
PMC - PMC7886454
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2021/02/14 06:00
MHDA- 2021/02/23 06:00
PMCR- 2021/02/12
CRDT- 2021/02/13 01:00
PHST- 2020/07/03 00:00 [received]
PHST- 2021/01/15 00:00 [accepted]
PHST- 2021/02/13 01:00 [entrez]
PHST- 2021/02/14 06:00 [pubmed]
PHST- 2021/02/23 06:00 [medline]
PHST- 2021/02/12 00:00 [pmc-release]
AID - 00005792-202102120-00077 [pii]
AID - MD-D-20-06299 [pii]
AID - 10.1097/MD.0000000000024638 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Feb 12;100(6):e24638. doi: 
      10.1097/MD.0000000000024638.