PMID- 33578871
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 57
IP  - 2
DP  - 2021 Feb 10
TI  - The Role of Exercise to Reduce the Impact of Diabetes in the Seminal Quality: A 
      Systematic Review.
LID - 10.3390/medicina57020159 [doi]
LID - 159
AB  - BackgroundandObjectives: One of the most relevant consequences of diabetes 
      mellitus is the temporal or complete infertility which can happen in young 
      individuals. Therefore, the current systematic review aimed to investigate the 
      effects of exercise to reduce the impact of Type 2 Diabetes Mellitus (T2DM) in 
      seminal quality and related parameters. MaterialsandMethods: A systematic search 
      was conducted in Pubmed and Web of Science databases following the Preferred 
      Reporting Items for Systematic Reviews and Meta-Analyses Guidelines (PRISMA). The 
      inclusion criteria were: (1) the study included at least one experimental and one 
      comparison group, (2) the sample of the study was comprised of humans or animals 
      with diabetes mellitus, (3) an intervention based on physical exercise was 
      conducted, and (4) the study reported variables related to the seminal quality. 
      Results: A total of 115 articles were identified. However, only six accomplished 
      the inclusion and exclusion criteria. This systematic review includes a sample 
      size of 260 participants (180 rats and 80 humans). Intervention ranged from 6 to 
      14 weeks, with 3-6 days per week. All interventions performed endurance training 
      (50-70% VO(2)max or maximum heart rate). Physical exercise increased sperm count, 
      motility, and morphology, as well as improved testosterone, Luteinizing Hormone 
      (LH), and Follicle Stimulating Hormone (FSH) levels. Moreover, physical exercise 
      intervention reduced the percentages of sperms with negative Tubular 
      Differentiation Index (TDI) and Spermiogenesis Index (SPI), DNA fragmentation, 
      and also ameliorated the diabetes-induced apoptosis and improved sperm apoptosis 
      index. Conclusions: Physical exercise could ameliorate diabetic pathological 
      effects on sperm quality and related parameters that cause infertility or 
      subfertility conditions. However, further homogeneous studies are needed to 
      confirm these findings.
FAU - Lavin-Perez, Ana Myriam
AU  - Lavin-Perez AM
AUID- ORCID: 0000-0001-9357-9987
AD  - Centre for Sport Studies, Rey Juan Carlos University, Fuenlabrada, 28943 Madrid, 
      Spain.
AD  - GO fitLAB, Ingesport, 28003 Madrid, Spain.
FAU - Collado-Mateo, Daniel
AU  - Collado-Mateo D
AUID- ORCID: 0000-0002-5140-465X
AD  - Centre for Sport Studies, Rey Juan Carlos University, Fuenlabrada, 28943 Madrid, 
      Spain.
FAU - Villafaina, Santos
AU  - Villafaina S
AUID- ORCID: 0000-0003-0784-1753
AD  - Physical Activity and Quality of Life Research Group (AFYCAV), Faculty of Sport 
      Sciences, University of Extremadura, 10004 Caceres, Spain.
FAU - Calle-Guisado, Violeta
AU  - Calle-Guisado V
AD  - Department of Specific Didactics, Faculty of Human Sciences and Education, 
      Experimental Sciences Area, University of Zaragoza, 50009 Zaragoza, Spain.
LA  - eng
GR  - PD16008/The regional department of economy and infrastructure of the Government 
      of Extremadura and the European Social Fund/
GR  - DIN2018- 010129/Spanish Ministry of Sciences, Innovation and Universities 
      (National Subprogram of Education)/
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20210210
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 3XMK78S47O (Testosterone)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - Animals
MH  - DNA Fragmentation
MH  - *Diabetes Mellitus, Type 2
MH  - Luteinizing Hormone
MH  - Male
MH  - Rats
MH  - Spermatozoa
MH  - Testosterone
PMC - PMC7916555
OTO - NOTNLM
OT  - animals
OT  - diabetes
OT  - fertility
OT  - human
OT  - physical exercise
OT  - sperm quality
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2021/02/14 06:00
MHDA- 2021/05/15 06:00
PMCR- 2021/02/10
CRDT- 2021/02/13 01:01
PHST- 2021/01/04 00:00 [received]
PHST- 2021/02/01 00:00 [revised]
PHST- 2021/02/02 00:00 [accepted]
PHST- 2021/02/13 01:01 [entrez]
PHST- 2021/02/14 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/02/10 00:00 [pmc-release]
AID - medicina57020159 [pii]
AID - medicina-57-00159 [pii]
AID - 10.3390/medicina57020159 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2021 Feb 10;57(2):159. doi: 10.3390/medicina57020159.