PMID- 33581328
OWN - NLM
STAT- MEDLINE
DCOM- 20220111
LR  - 20220111
IS  - 1567-7257 (Electronic)
IS  - 1567-1348 (Linking)
VI  - 90
DP  - 2021 Jun
TI  - Molecular characterization and pathogenicity of a fowl adenovirus serotype 4 
      isolated from peacocks associated with hydropericardium hepatitis syndrome.
PG  - 104766
LID - S1567-1348(21)00063-0 [pii]
LID - 10.1016/j.meegid.2021.104766 [doi]
AB  - In September 2019, a highly prevalent infectious disease caused severe 
      hydropericardium hepatitis syndrome (HHS) in a peacock farm in Central China. The 
      disease showed high mortality of 78.6% in 28-42 day-old peacocks. In this study, 
      one strain of highly pathogenic fowl adenovirus serotype 4 (FAdV-4) was isolated 
      from peacocks and designated as HN19. Molecular characterization of amino acid 
      revealed that HN19 contains the same deletions as the dominate strains in 
      chickens in China recently. Phylogenetic analyses revealed that HN19 showed 
      higher homology with other FAdV-4 strains isolated from China, indicating that 
      HN19 might originate from previously FAdV-4 predecessor in China. Experimental 
      infection of the HN19 strain via intramuscular injection led to 100% mortality 
      rate in 21-day-old specific pathogenic-free (SPF) chickens. To our knowledge, 
      this represents the first report on the prevalence of FAdV-4 in peacocks. These 
      results suggested that the potential risk of cross-species transmission of FAdV-4 
      from chickens to peacocks, highlighting the need for implementing strict 
      biosecurity measures to avoid the mixing of different bird species.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Wang, Xinwei
AU  - Wang X
AD  - College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
FAU - Li, Danyang
AU  - Li D
AD  - College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
FAU - Deng, Yu
AU  - Deng Y
AD  - College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
FAU - Yang, Xia
AU  - Yang X
AD  - College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
FAU - Li, Yongtao
AU  - Li Y
AD  - College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
FAU - Wang, Zeng
AU  - Wang Z
AD  - College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
FAU - Chang, Hongtao
AU  - Chang H
AD  - College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China. 
      Electronic address: ndcht@163.com.
FAU - Liu, Huimin
AU  - Liu H
AD  - College of Life Science, Henan Agricultural University, Zhengzhou, China. 
      Electronic address: liuhuimin@henau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210210
PL  - Netherlands
TA  - Infect Genet Evol
JT  - Infection, genetics and evolution : journal of molecular epidemiology and 
      evolutionary genetics in infectious diseases
JID - 101084138
SB  - IM
MH  - Adenoviridae Infections/*veterinary/virology
MH  - Animals
MH  - Aviadenovirus/*classification/*pathogenicity
MH  - Chickens
MH  - *Galliformes
MH  - Pericardial Effusion/*veterinary/virology
MH  - Poultry Diseases/*virology
MH  - Specific Pathogen-Free Organisms
MH  - Virulence
OTO - NOTNLM
OT  - Cross-species
OT  - Fowl adenovirus serotype 4
OT  - Hydropericardium hepatitis syndrome
OT  - Peacock
EDAT- 2021/02/14 06:00
MHDA- 2022/01/12 06:00
CRDT- 2021/02/13 20:10
PHST- 2021/01/08 00:00 [received]
PHST- 2021/02/04 00:00 [revised]
PHST- 2021/02/08 00:00 [accepted]
PHST- 2021/02/14 06:00 [pubmed]
PHST- 2022/01/12 06:00 [medline]
PHST- 2021/02/13 20:10 [entrez]
AID - S1567-1348(21)00063-0 [pii]
AID - 10.1016/j.meegid.2021.104766 [doi]
PST - ppublish
SO  - Infect Genet Evol. 2021 Jun;90:104766. doi: 10.1016/j.meegid.2021.104766. Epub 
      2021 Feb 10.