PMID- 33582342
OWN - NLM
STAT- MEDLINE
DCOM- 20210406
LR  - 20210406
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 773
DP  - 2021 Jun 15
TI  - A review of human and animals exposure to polycyclic aromatic hydrocarbons: 
      Health risk and adverse effects, photo-induced toxicity and regulating effect of 
      microplastics.
PG  - 145403
LID - S0048-9697(21)00471-X [pii]
LID - 10.1016/j.scitotenv.2021.145403 [doi]
AB  - Polycyclic aromatic hydrocarbons (PAHs) are one of the most widely distributed 
      persistent organic pollutants (POPs) in the environmental media. PAHs have been 
      widely concerned due to their significant health risk and adverse effects to 
      human and animals. Currently, the main sources of PAHs in the environment are the 
      incomplete combustion of fossil fuels, as well as municipal waste incineration 
      and agricultural non-surface source emissions. In this work, the scope of our 
      attention includes 16 typical PAHs themselves without involving their metabolites 
      and industrial by-products. Exposure of human and animals to PAHs can lead to a 
      variety of adverse effects, including carcinogenicity and teratogenicity, 
      genotoxicity, reproductive- and endocrine-disrupting effects, immunotoxicity and 
      neurotoxicity, the type and severity of which depend on a variety of factors. On 
      the other hand, the regulatory effect of microplastics (MPs) on the bio-toxicity 
      and bioaccumulation capacity of PAHs has now gradually attracted attention. We 
      critically reviewed the adsorption capacity and mechanisms of MPs on PAHs as well 
      as the effects of MPs on PAHs toxicity, thus highlighting the importance of 
      paying attention to the joint bio-toxicity caused by PAHs-MPs interactions. In 
      addition, due to the extensive nature of the common exposure pathway of PAHs and 
      ultraviolet ray, an accurate understanding of biological processes exposed to 
      both PAHs and UV light is necessary to develop effective protective strategies. 
      Finally, based on the above critical review, we highlighted the research gaps and 
      pointed out the priority of further studies.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Sun, Kailun
AU  - Sun K
AD  - School of Environmental Science and Engineering, Shandong University, 
      China-America CRC for Environment & Health, 72# Jimo Binhai Road, Qingdao, 
      Shandong 266237, PR China.
FAU - Song, Yan
AU  - Song Y
AD  - School of Water Conservancy and Environment, University of Jinan, Jinan, Shandong 
      Province 250022, China.
FAU - He, Falin
AU  - He F
AD  - School of Environmental Science and Engineering, Shandong University, 
      China-America CRC for Environment & Health, 72# Jimo Binhai Road, Qingdao, 
      Shandong 266237, PR China.
FAU - Jing, Mingyang
AU  - Jing M
AD  - School of Environmental Science and Engineering, Shandong University, 
      China-America CRC for Environment & Health, 72# Jimo Binhai Road, Qingdao, 
      Shandong 266237, PR China.
FAU - Tang, Jingchun
AU  - Tang J
AD  - Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of 
      Education), Tianjin Engineering Research Center of Environmental Diagnosis and 
      Contamination Remediation, College of Environmental Science and Engineering, 
      Nankai University, Tianjin 300350, China.
FAU - Liu, Rutao
AU  - Liu R
AD  - School of Environmental Science and Engineering, Shandong University, 
      China-America CRC for Environment & Health, 72# Jimo Binhai Road, Qingdao, 
      Shandong 266237, PR China. Electronic address: rutaoliu@sdu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210128
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Microplastics)
RN  - 0 (Plastics)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
SB  - IM
MH  - Animals
MH  - Bioaccumulation
MH  - Environmental Monitoring
MH  - Humans
MH  - Incineration
MH  - Microplastics
MH  - Plastics
MH  - *Polycyclic Aromatic Hydrocarbons/analysis/toxicity
OTO - NOTNLM
OT  - Health risk
OT  - Human and animals
OT  - Microplastics
OT  - Photo-induced toxicity
OT  - Polycyclic aromatic hydrocarbons (PAHs)
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/02/15 06:00
MHDA- 2021/04/07 06:00
CRDT- 2021/02/14 20:28
PHST- 2020/11/11 00:00 [received]
PHST- 2021/01/18 00:00 [revised]
PHST- 2021/01/20 00:00 [accepted]
PHST- 2021/02/15 06:00 [pubmed]
PHST- 2021/04/07 06:00 [medline]
PHST- 2021/02/14 20:28 [entrez]
AID - S0048-9697(21)00471-X [pii]
AID - 10.1016/j.scitotenv.2021.145403 [doi]
PST - ppublish
SO  - Sci Total Environ. 2021 Jun 15;773:145403. doi: 10.1016/j.scitotenv.2021.145403. 
      Epub 2021 Jan 28.