PMID- 33582569
OWN - NLM
STAT- MEDLINE
DCOM- 20211130
LR  - 20211130
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 101
DP  - 2021 May
TI  - High-resolution mapping identifies HLA class II associations with multifocal 
      motor neuropathy.
PG  - 79-84
LID - S0197-4580(21)00021-X [pii]
LID - 10.1016/j.neurobiolaging.2021.01.014 [doi]
AB  - OBJECTIVE: To gain further insight in the immunopathology underlying multifocal 
      motor neuropathy (MMN) by exploring the association between MMN and the human 
      leukocyte antigen (HLA) class II DRB1, DQB1, and DQA loci in depth and by 
      correlating associated haplotypes to detailed clinical and anti-ganglioside 
      antibody data. METHODS: We performed high-resolution HLA-class II typing for the 
      DRB1, DQB1, and DQA1 loci in 126 well-characterized MMN patients and assessed 
      disease associations with haplotypes. We used a cohort of 1305 random individuals 
      as a reference for haplotype distribution in the Dutch population. RESULTS: The 
      DRB1*15:01-DQB1*06:02 haplotype (OR 1.6 [95% CI 1.1-2.2], p < 0.05) and the 
      DRB1*12:01-DQB1*03:01 haplotype (OR 2.7 [95% CI 1.2-5.5], p < 0.05) were more 
      frequent in patients with MMN than in controls. These haplotypes were not 
      associated with disease course, response to treatment or anti-ganglioside 
      antibodies. CONCLUSIONS: MMN is associated with the DRB1*15:01-DQB1*06:02 and 
      DRB1*12:01-DQB1*03:01 haplotypes. These HLA molecules or gene variants in their 
      immediate vicinity may promote the specific inflammatory processes underlying 
      MMN.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Bos, Jeroen W
AU  - Bos JW
AD  - UMC Utrecht Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, 
      Utrecht, the Netherlands.
FAU - Otten, Henny G
AU  - Otten HG
AD  - Department of Immunology, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Herraets, Ingrid J T
AU  - Herraets IJT
AD  - UMC Utrecht Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, 
      Utrecht, the Netherlands.
FAU - Goedee, H Stephan
AU  - Goedee HS
AD  - UMC Utrecht Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, 
      Utrecht, the Netherlands.
FAU - Cats, E A
AU  - Cats EA
AD  - UMC Utrecht Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, 
      Utrecht, the Netherlands.
FAU - de Hoop, Talitha
AU  - de Hoop T
AD  - Department of Immunology, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Verduijn, Willem
AU  - Verduijn W
AD  - Department of Immunohematology and Blood Transfusion, Leiden University Medical 
      Centre, Leiden, the Netherlands.
FAU - van der Pol, W Ludo
AU  - van der Pol WL
AD  - UMC Utrecht Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, 
      Utrecht, the Netherlands.
FAU - van den Berg, Leonard H
AU  - van den Berg LH
AD  - UMC Utrecht Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, 
      Utrecht, the Netherlands. Electronic address: l.h.vandenberg@umcutrecht.nl.
LA  - eng
PT  - Journal Article
DEP - 20210120
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Gangliosides)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DR beta-Chains)
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Gangliosides/immunology
MH  - Genetic Association Studies/*methods
MH  - Genetic Loci
MH  - Genetic Predisposition to Disease/*genetics
MH  - HLA-DQ alpha-Chains/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DR beta-Chains/*genetics
MH  - Haplotypes
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Polyneuropathies/*genetics
OTO - NOTNLM
OT  - Anti-ganglioside antibodies
OT  - Human leucocyte antigen
OT  - Multifocal motor neuropathy
OT  - Neuroimmunology
EDAT- 2021/02/15 06:00
MHDA- 2021/12/01 06:00
CRDT- 2021/02/14 20:33
PHST- 2020/07/24 00:00 [received]
PHST- 2020/12/10 00:00 [revised]
PHST- 2021/01/16 00:00 [accepted]
PHST- 2021/02/15 06:00 [pubmed]
PHST- 2021/12/01 06:00 [medline]
PHST- 2021/02/14 20:33 [entrez]
AID - S0197-4580(21)00021-X [pii]
AID - 10.1016/j.neurobiolaging.2021.01.014 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2021 May;101:79-84. doi: 10.1016/j.neurobiolaging.2021.01.014. 
      Epub 2021 Jan 20.