PMID- 33582671
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20211124
IS  - 1423-0399 (Electronic)
IS  - 0042-1138 (Linking)
VI  - 105
IP  - 7-8
DP  - 2021
TI  - The Impact of Fluorescence in situ Hybridization on the Staging of Upper Tract 
      Urothelial Carcinoma.
PG  - 631-636
LID - 10.1159/000513459 [doi]
AB  - OBJECTIVES: The aim of the study was to evaluate the impact of fluorescence in 
      situ hybridization (FISH) diagnostics on the T stage in final histology specimen 
      of patients undergoing radical nephroureterectomy (RNU) due to upper tract 
      urothelial carcinoma (UTUC) at a large tertiary care center. METHODS: We 
      retrospectively analyzed patients who underwent RNU at our center between 2008 
      and 2020. Inclusion criteria were RNU due to UTUC. Urine cytologies were used for 
      FISH analysis to detect chromosomal abnormalities. Pre-FISH group was defined as 
      patients without access to routine preoperative urinary FISH testing (2008-2014), 
      and FISH group was defined as patients with access to routine FISH testing. 
      Primary outcome was T stage in final histology. Statistical analysis was 
      performed by chi2 test and Mann-Whitney U test. RESULTS: Out of 212 patients who 
      underwent RNU at our center between 2008 and 2020, 155 patients were included 
      into the final analysis. The median age was 71 (range 33-90) years, and 108 
      (69.7%) patients were male and 47 (30.3%) female. Age and gender were not 
      differently distributed in both groups (age: p = 0.925; gender: p = 0.682). 
      Organ-confined disease was found in 37/72 patients in the pre-FISH cohort and in 
      48/83 patients in the FISH cohort (p = 0.422). Within organ-confined disease, 
      18/37 patients revealed a T stage smaller than T1 in the pre-FISH cohort and 
      35/48 patients in the FISH cohort (p = 0.022). CONCLUSIONS: Preoperative FISH 
      diagnostics add important information to preoperative diagnostic workup of 
      patients with UTUC. Within organ-confined disease, a significant shift toward T 
      stages lower than T1 is observed. Further research is required to determine the 
      impact of this shift on survival in UTUC.
CI  - (c) 2021 S. Karger AG, Basel.
FAU - Eismann, Lennert
AU  - Eismann L
AD  - Department of Urology, Klinikum der Universitat Munchen, Munich, Germany, 
      lennert.eismann@gmx.net.
FAU - Mumm, Jan-Niclas
AU  - Mumm JN
AD  - Department of Urology, Klinikum der Universitat Munchen, Munich, Germany.
FAU - Bohn, Lucas
AU  - Bohn L
AD  - Department of Urology, Klinikum der Universitat Munchen, Munich, Germany.
FAU - Wulfing, Christian
AU  - Wulfing C
AD  - Department of Urology, Asklepios Klinik Hamburg Altona, Hamburg, Germany.
FAU - Knuchel-Clarke, Ruth
AU  - Knuchel-Clarke R
AD  - Institute of Pathology, Uniklinik RWTH Aachen, Aachen, Germany.
FAU - Casuscelli, Jozefina
AU  - Casuscelli J
AD  - Department of Urology, Klinikum der Universitat Munchen, Munich, Germany.
FAU - Waidelich, Raphaela
AU  - Waidelich R
AD  - Department of Urology, Klinikum der Universitat Munchen, Munich, Germany.
FAU - Stief, Christian G
AU  - Stief CG
AD  - Department of Urology, Klinikum der Universitat Munchen, Munich, Germany.
FAU - Schlenker, Boris
AU  - Schlenker B
AD  - Department of Urology, Klinikum der Universitat Munchen, Munich, Germany.
FAU - Rodler, Severin
AU  - Rodler S
AD  - Department of Urology, Klinikum der Universitat Munchen, Munich, Germany.
LA  - eng
PT  - Journal Article
DEP - 20210212
PL  - Switzerland
TA  - Urol Int
JT  - Urologia internationalis
JID - 0417373
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Transitional Cell/*pathology/surgery
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Nephroureterectomy
MH  - Retrospective Studies
MH  - Ureteral Neoplasms/*pathology/surgery
OTO - NOTNLM
OT  - Cytology
OT  - Fluorescence in situ hybridization
OT  - Radical nephroureterectomy
OT  - Stage development
OT  - Upper tract urothelial carcinoma
EDAT- 2021/02/15 06:00
MHDA- 2021/11/25 06:00
CRDT- 2021/02/14 20:36
PHST- 2020/09/28 00:00 [received]
PHST- 2020/11/28 00:00 [accepted]
PHST- 2021/02/15 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
PHST- 2021/02/14 20:36 [entrez]
AID - 000513459 [pii]
AID - 10.1159/000513459 [doi]
PST - ppublish
SO  - Urol Int. 2021;105(7-8):631-636. doi: 10.1159/000513459. Epub 2021 Feb 12.