PMID- 33582883
OWN - NLM
STAT- MEDLINE
DCOM- 20220615
LR  - 20220615
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
VI  - 273
DP  - 2022
TI  - New Insights in the Complexity and Functionality of the Neurovascular Unit.
PG  - 33-57
LID - 10.1007/164_2020_424 [doi]
AB  - The neurovascular unit (NVU) encompasses all brain cells and underlines that 
      neurons, glia and brain vasculature are in intimate physical and functional 
      association. Brain function is dependent on blood flow and local increases in 
      blood flow in response to neural activity - functional hyperaemia takes place at 
      the NVU. Although this is a vital function of the NVU, many studies have 
      demonstrated that the NVU also performs other tasks. Blood vessels in the brain, 
      which are composed of multiple cell types, are essential for correct brain 
      development. They constitute the niche for brain stem cells, sense the 
      environment and communicate changes to neural tissue, and control the immune 
      quiescence of the CNS. In this brief chapter we will discuss new insights into 
      the biology of NVU, which have further revealed the heterogeneity and complexity 
      of the vascular tree and its neurovascular associations.
CI  - (c) 2020. Springer Nature Switzerland AG.
FAU - Schaffenrath, Johanna
AU  - Schaffenrath J
AD  - Department of Neurosurgery, Clinical Neuroscience Center, Zurich Neuroscience 
      Center, Zurich University Hospital, Zurich University, Zurich, Switzerland.
FAU - Keller, Annika
AU  - Keller A
AD  - Department of Neurosurgery, Clinical Neuroscience Center, Zurich Neuroscience 
      Center, Zurich University Hospital, Zurich University, Zurich, Switzerland. 
      annika.keller@usz.ch.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
SB  - IM
MH  - Blood-Brain Barrier/metabolism
MH  - *Brain
MH  - Humans
MH  - Neuroglia
MH  - *Neurons/metabolism
OTO - NOTNLM
OT  - Astrocyte
OT  - Endothelium
OT  - Microglia
OT  - Neurovascular unit
OT  - Pericyte
OT  - Perivascular fibroblast-like cell
OT  - Perivascular macrophage
OT  - Structural diversity
OT  - Vascular smooth muscle cell
EDAT- 2021/02/15 06:00
MHDA- 2022/06/16 06:00
CRDT- 2021/02/14 20:37
PHST- 2021/02/15 06:00 [pubmed]
PHST- 2022/06/16 06:00 [medline]
PHST- 2021/02/14 20:37 [entrez]
AID - 10.1007/164_2020_424 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2022;273:33-57. doi: 10.1007/164_2020_424.