PMID- 33583139
OWN - NLM
STAT- MEDLINE
DCOM- 20210707
LR  - 20210707
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Linking)
VI  - 97
IP  - 5
DP  - 2021 May
TI  - Molecular analysis of HLA Class I and Class II genes in five different South 
      Indian linguistic groups.
PG  - 399-419
LID - 10.1111/tan.14219 [doi]
AB  - South Indians are a heterogeneous population who speak different languages and 
      differ in their life style and physical appearance. Major population movements, 
      social structure and caste endogamy have influenced the genetic structure of 
      Indian populations. The human leukocyte antigen (HLA) system of populations is 
      highly informative because of the high level of polymorphisms. Knowledge of 
      allele and haplotype frequencies of the HLA system is important in the search for 
      unrelated bone marrow donors. We investigated the distribution of HLA A, B, C, 
      DRB1 and DQB1 loci in five linguistic groups from South India. 
      HLA-A*01:01:01~B*57:01:01:01~C*06:02:01~DRB1*07:01:01~DQB1*03:03:02 was the 
      common haplotype with highest frequency in all the five populations studied. A 
      few relevant haplotypes were identified as most common haplotypes in each 
      linguistic group. Comparison of HLA-A, -B and -DRB1 allele distribution in these 
      five linguistic groups with the other Asian population showed that the South 
      Indian populations were closely related to Sri Lankan populations. A large South 
      Indian donor registry might serve as good source of donors for patients from Sri 
      Lanka and vice versa.
CI  - (c) 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Seshasubramanian, Vani
AU  - Seshasubramanian V
AUID- ORCID: 0000-0002-6399-7499
AD  - JEENOMICS (NGS HLA laboratory), Jeevan Stem Cell Foundation, Chennai, India.
FAU - SathishKannan, Aruna Devi
AU  - SathishKannan AD
AD  - JEENOMICS (NGS HLA laboratory), Jeevan Stem Cell Foundation, Chennai, India.
FAU - Naganathan, Chandramouleeswaran
AU  - Naganathan C
AD  - JEENOMICS (NGS HLA laboratory), Jeevan Stem Cell Foundation, Chennai, India.
FAU - Narayan, Saranya
AU  - Narayan S
AD  - JEENOMICS (NGS HLA laboratory), Jeevan Stem Cell Foundation, Chennai, India.
FAU - Periathiruvadi, Srinivasan
AU  - Periathiruvadi S
AD  - JEENOMICS (NGS HLA laboratory), Jeevan Stem Cell Foundation, Chennai, India.
LA  - eng
PT  - Journal Article
DEP - 20210226
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Gene Frequency
MH  - *Genes, MHC Class II
MH  - HLA-DQ beta-Chains/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Humans
MH  - India
MH  - *Linguistics
OTO - NOTNLM
OT  - HLA
OT  - molecular analysis
OT  - south Indian population
EDAT- 2021/02/15 06:00
MHDA- 2021/07/08 06:00
CRDT- 2021/02/14 20:41
PHST- 2021/01/16 00:00 [revised]
PHST- 2020/01/14 00:00 [received]
PHST- 2021/02/08 00:00 [accepted]
PHST- 2021/02/15 06:00 [pubmed]
PHST- 2021/07/08 06:00 [medline]
PHST- 2021/02/14 20:41 [entrez]
AID - 10.1111/tan.14219 [doi]
PST - ppublish
SO  - HLA. 2021 May;97(5):399-419. doi: 10.1111/tan.14219. Epub 2021 Feb 26.