PMID- 33583337
OWN - NLM
STAT- MEDLINE
DCOM- 20221121
LR  - 20221121
IS  - 1532-2378 (Electronic)
IS  - 1049-5398 (Linking)
VI  - 33
IP  - 6
DP  - 2022 Nov
TI  - Deletions in the KAP6-1 gene are associated with fiber traits in 
      cashmere-producing goats.
PG  - 1198-1204
LID - 10.1080/10495398.2021.1881529 [doi]
AB  - Keratin-associated proteins (KAPs) are important structural components of fibers 
      that predominantly present in the ortho-cortex. These proteins form a 
      cross-linked network with keratin intermediate filaments (KIFs), thus producing a 
      strong hair shaft. The keratin-associated protein 6-1 gene (KAP6-1) is a member 
      of the KAPs family that has a potential correlation with fiber traits. In this 
      study, we investigated the influence of KAP6-1 sequence polymorphisms on the 
      fiber characteristics of a Chinese cashmere-producing goat breed (n = 844). Two 
      main variants were found, including a three base pair (bp) deletion (namely B) 
      and a 36-bp deletion (namely C), while the reference genotype of KAP6-1 was named 
      A. Among them, the B variant was first reported on cashmere goats. This study 
      then correlated these genotypes with the collected fiber data to investigate the 
      potential association of these variants. The results showed that variant A is 
      associated with decreased fiber diameter (p < 0.01), while variant C is 
      associated with deceased fiber length (p < 0.01). These two related variants of 
      the KAP6-1 gene have potential applications as gene-makers to improve the fiber 
      diameter and length in cashmere-producing goats.
FAU - Zhao, Jin
AU  - Zhao J
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      China.
FAU - Ding, Qiang
AU  - Ding Q
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      China.
FAU - Li, Lan
AU  - Li L
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      China.
FAU - Kalds, Peter
AU  - Kalds P
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      China.
FAU - Zhou, Shiwei
AU  - Zhou S
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      China.
FAU - Sun, Jiayuan
AU  - Sun J
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      China.
FAU - Huang, Shuhong
AU  - Huang S
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      China.
FAU - Wang, Xiaolong
AU  - Wang X
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      China.
FAU - Chen, Yulin
AU  - Chen Y
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, 
      College of Animal Science and Technology, Northwest A&F University, Yangling, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20210213
PL  - England
TA  - Anim Biotechnol
JT  - Animal biotechnology
JID - 9011409
RN  - 68238-35-7 (Keratins)
SB  - IM
MH  - Animals
MH  - *Goats/genetics/metabolism
MH  - Phenotype
MH  - *Keratins/chemistry/genetics/metabolism
MH  - Genotype
MH  - Hair
OTO - NOTNLM
OT  - Cashmere-producing goats
OT  - KAP6-1 gene
OT  - KAPs family
OT  - fiber traits
OT  - variant associations
EDAT- 2021/02/16 06:00
MHDA- 2022/11/22 06:00
CRDT- 2021/02/15 05:35
PHST- 2021/02/16 06:00 [pubmed]
PHST- 2022/11/22 06:00 [medline]
PHST- 2021/02/15 05:35 [entrez]
AID - 10.1080/10495398.2021.1881529 [doi]
PST - ppublish
SO  - Anim Biotechnol. 2022 Nov;33(6):1198-1204. doi: 10.1080/10495398.2021.1881529. 
      Epub 2021 Feb 13.