PMID- 33583389
OWN - NLM
STAT- MEDLINE
DCOM- 20220112
LR  - 20220112
IS  - 1996-3181 (Electronic)
IS  - 1871-5273 (Linking)
VI  - 20
IP  - 7
DP  - 2021
TI  - Cellular and Molecular Mechanisms of Dementia: Decoding the Causal link of 
      Diabetes Mellitus in Alzheimer's Disease.
PG  - 602-612
LID - 10.2174/1871527320666210212114116 [doi]
AB  - Dementia and diabetes are the two major disorders that are linked at both 
      biochemical and molecular levels, which is due to the existing similarities 
      between pancreatic beta-cells and neuronal cells at the transcriptional and 
      translational levels. Both diseases have similar causative genes or factors, and 
      dementia is one of the advanced complications in about 50-52% of patients with 
      Type 2 Diabetes Mellitus (T2DM). Further, patients with T2DM are at a higher risk 
      of neuronal degeneration and Alzheimer's Disease (AD). Dementia, which is most 
      common in AD, is associated with diminished insulin receptors by nearly 80%. The 
      impairment in insulin signaling thus leads to the development of dementia and AD. 
      Biochemical changes in 'tau' protein and amyloid-- beta proteins make them 
      critical players in the formation of plaques in patients with dementia and AD. 
      Here, we decode various cellular and molecular mechanisms associated with the 
      development of dementia in patients with diabetes and AD.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Rasool, Mahmood
AU  - Rasool M
AD  - Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical 
      Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Malik, Arif
AU  - Malik A
AD  - Institute of Molecular Biology & Biotechnology (IMBB), the University of Lahore, 
      Lahore, Pakistan.
FAU - Waquar, Sulayman
AU  - Waquar S
AD  - Institute of Molecular Biology & Biotechnology (IMBB), the University of Lahore, 
      Lahore, Pakistan.
FAU - Zaheer, Ahmad
AU  - Zaheer A
AD  - Institute of Molecular Biology & Biotechnology (IMBB), the University of Lahore, 
      Lahore, Pakistan.
FAU - Asif, Muhammad
AU  - Asif M
AD  - Department of Biotechnology, BUITEMS, Quetta, Pakistan.
FAU - Iqbal, Zafar
AU  - Iqbal Z
AD  - King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical 
      City, National Guard Health Affairs, Riyadh, Saudi Arabia.
FAU - Gauthaman, Kalamegam
AU  - Gauthaman K
AD  - Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical 
      Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Kamal, Mohammad Amjad
AU  - Kamal MA
AD  - King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi 
      Arabia.
FAU - Pushparaj, Peter Natesan
AU  - Pushparaj PN
AD  - Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical 
      Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
LA  - eng
GR  - 13-MED2437-03/National Plan for Science, Technology, and Innovation 
      (MAARIFAH)-King Abdulaziz City for Science and Technology, the Kingdom of Saudi 
      Arabia/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - CNS Neurol Disord Drug Targets
JT  - CNS & neurological disorders drug targets
JID - 101269155
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Insulin)
RN  - 0 (MAPT protein, human)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Alzheimer Disease/etiology/*metabolism
MH  - Amyloid beta-Peptides/metabolism
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Humans
MH  - Insulin/metabolism
MH  - Signal Transduction
MH  - tau Proteins/metabolism
OTO - NOTNLM
OT  - AD (alzheimer disease)
OT  - Dementia
OT  - T2DM (Type 2 diabetes mellitus)
OT  - biochemical
OT  - disorders
OT  - pancreatic.
EDAT- 2021/02/16 06:00
MHDA- 2022/01/13 06:00
CRDT- 2021/02/15 05:35
PHST- 2020/07/23 00:00 [received]
PHST- 2020/10/07 00:00 [revised]
PHST- 2020/10/26 00:00 [accepted]
PHST- 2021/02/16 06:00 [pubmed]
PHST- 2022/01/13 06:00 [medline]
PHST- 2021/02/15 05:35 [entrez]
AID - CNSNDDT-EPUB-114157 [pii]
AID - 10.2174/1871527320666210212114116 [doi]
PST - ppublish
SO  - CNS Neurol Disord Drug Targets. 2021;20(7):602-612. doi: 
      10.2174/1871527320666210212114116.