PMID- 33585991 OWN - NLM STAT- MEDLINE DCOM- 20210713 LR - 20240402 IS - 1432-1084 (Electronic) IS - 0938-7994 (Print) IS - 0938-7994 (Linking) VI - 31 IP - 8 DP - 2021 Aug TI - Stent placement combined with intraluminal radiofrequency ablation and hepatic arterial infusion chemotherapy for advanced biliary tract cancers with biliary obstruction: a multicentre, retrospective, controlled study. PG - 5851-5862 LID - 10.1007/s00330-021-07716-0 [doi] AB - OBJECTIVE: To evaluate the efficacy and safety of stent placement combined with intraluminal radiofrequency ablation (intra-RFA) and hepatic arterial infusion chemotherapy (HAIC) for patients with advanced biliary tract cancers (Ad-BTCs) and biliary obstruction (BO). METHODS: We retrospectively reviewed data for patients with Ad-BTCs and BO who underwent stent placement with or without intra-RFA and HAIC in three centres between November 2013 and November 2018. The stent patency time (SPT), overall survival (OS), and adverse events (AEs) were analysed. RESULTS: Of the 135 enrolled patients, 64 underwent stent placement combined with intra-RFA and HAIC, while 71 underwent only stent placement. The median SPT was significantly longer in the combination group (8.2 months, 95% confidence interval [CI]: 7.1-9.3) than in the control group (4.3 months, 95% CI: 3.6-5.0; p < 0.001). A similar result was observed for OS (combination: 13.2 months, 95% CI: 11.1-16.5; control: 8.5 months, 95% CI: 7.6-9.6; p < 0.001). The incidence of AEs related to biliary tract operation was not significantly different between the two groups (p > 0.05). The most common AE and serious AE related to HAIC were alanine aminotransferase elevation (24/64; 37.5%) and thrombocytopenia (8/64; 12.5%), respectively. All AEs were tolerable, and there was no death from AEs. CONCLUSIONS: Stent placement combined with intra-RFA and HAIC may be a safe, potential treatment strategy for patients with Ad-BTCs and BO. KEY POINTS: * Advanced biliary cancers (Ad-BTCs) with biliary obstruction (BO) can rapidly result in liver failure and cachexia with an extremely poor prognosis. * Stent placement combined with intraluminal radiofrequency ablation and hepatic arterial infusion chemotherapy may be safe and effective for patients with Ad-BTCs and BO. * The long-term efficacy and safety of the combined treatment is promising. CI - (c) 2021. The Author(s). FAU - Gou, Qing AU - Gou Q AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Wu, Lingeng AU - Wu L AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Cui, Wei AU - Cui W AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Mo, Zhiqiang AU - Mo Z AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Zeng, Dejin AU - Zeng D AD - Department of Gastroenterology, Zhongshan Hospital of traditional Chinese Medicine, Zhongshan, 528400, Guangdong, China. FAU - Gan, Liming AU - Gan L AD - Department of Gastroenterology, Zhongshan Hospital of traditional Chinese Medicine, Zhongshan, 528400, Guangdong, China. FAU - He, Jian AU - He J AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Mai, Qicong AU - Mai Q AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Shi, Feng AU - Shi F AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Chen, Meng AU - Chen M AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Sun, Zhonghai AU - Sun Z AD - Department of General Surgery, Guangdong Provincial Peoples Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China. FAU - Liu, Yongdong AU - Liu Y AD - Department of Catheterization Lab, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China. FAU - Wu, Jingjing AU - Wu J AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Chen, Xiumei AU - Chen X AD - Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, 510080, Guangdong, China. FAU - Zhuang, Wenhang AU - Zhuang W AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Xu, Rongde AU - Xu R AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Li, Weike AU - Li W AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Cai, Qichun AU - Cai Q AD - Department of Oncology, Cancer Center, Guangdong Clifford Hospital, Guangzhou, 511400, Guangdong, China. FAU - Zhang, Jing AU - Zhang J AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Chen, Xiaoming AU - Chen X AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. FAU - Li, Jiaping AU - Li J AD - Department of Interventional Oncology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China. jiapingli3s@126.com. FAU - Zhou, Zejian AU - Zhou Z AUID- ORCID: 0000-0001-8315-4280 AD - Department of Interventional Therapy, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, 106 Zhongshan Second Road, Guangzhou, 510080, Guangdong, China. zhzejian@126.com. LA - eng PT - Controlled Clinical Trial PT - Journal Article PT - Multicenter Study DEP - 20210213 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 SB - IM MH - *Biliary Tract Neoplasms/complications/therapy MH - *Catheter Ablation MH - *Cholestasis/surgery MH - Humans MH - *Radiofrequency Ablation MH - Retrospective Studies MH - Stents MH - Treatment Outcome PMC - PMC8270826 OTO - NOTNLM OT - Biliary tract neoplasms OT - Catheter ablation OT - Cholestasis OT - Infusions OT - Intra-arterial COIS- The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. EDAT- 2021/02/16 06:00 MHDA- 2021/07/14 06:00 PMCR- 2021/02/13 CRDT- 2021/02/15 06:13 PHST- 2020/06/16 00:00 [received] PHST- 2021/01/26 00:00 [accepted] PHST- 2020/11/23 00:00 [revised] PHST- 2021/02/16 06:00 [pubmed] PHST- 2021/07/14 06:00 [medline] PHST- 2021/02/15 06:13 [entrez] PHST- 2021/02/13 00:00 [pmc-release] AID - 10.1007/s00330-021-07716-0 [pii] AID - 7716 [pii] AID - 10.1007/s00330-021-07716-0 [doi] PST - ppublish SO - Eur Radiol. 2021 Aug;31(8):5851-5862. doi: 10.1007/s00330-021-07716-0. Epub 2021 Feb 13.