PMID- 33586916
OWN - NLM
STAT- MEDLINE
DCOM- 20210630
LR  - 20210630
IS  - 2162-3279 (Electronic)
VI  - 11
IP  - 4
DP  - 2021 Apr
TI  - Crocin mitigated cognitive impairment and brain molecular alterations induced by 
      different intensities of prenatal hypoxia in neonatal rats.
PG  - e02078
LID - 10.1002/brb3.2078 [doi]
LID - e02078
AB  - INTRODUCTION: Brain hypoxia has important role to the onset and progression of 
      sporadic form of Alzheimer disease via expression of hypoxia-inducible factor-1 
      (HIF-1). Crocin by anti-amyloidogenic property inhibits beta-amyloid formation. 
      However, the molecular mechanism associated with anti-amyloidogenic activity of 
      crocin is unknown. So, the present study was designed to investigate the effect 
      of crocin on cognitive behavior and expression of HIF-1alpha and beta-secretase (BACE1) 
      genes in the brain of neonate rats following different intensities of hypoxia 
      during pregnancy. MATERIAL AND METHODS: Pregnant female rats were divided into 
      six groups including sham, control crocin treated (CC), hypoxia with three 
      different intensities (H1-H3), and most intense of hypoxic group treated with 
      crocin (H3C) (30 mg/kg; i.p) at P14. Hypoxia induced on the 20th day of 
      pregnancy. Animals in sham and CC were put in hypoxia chamber at the same time of 
      hypoxia group without any hypoxia induction. Morris water maze (MWM) and qRT-PCR 
      were used to evaluate the cognitive behavior and mRNA levels of BACE1 and HIF-1alpha 
      genes in the brain tissues. RESULTS: Animal under 7% O(2)  + 93% N(2) condition 
      for 3 hr showed the highest cognitive behavior impairment and upregulated HIF-1alpha 
      and BACE1 mRNA in brains of offspring (p < .001). Crocin treatment improved 
      memory impairment and attenuated the gene expression of HIF-1alpha and BACE1 in the 
      brains of neonate rat. CONCLUSIONS: It was concluded that crocin has beneficial 
      effects on the brain of neonate rats under gestational hypoxia by improvement of 
      memory impairment and molecular alteration related to hypoxia.
CI  - (c) 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
FAU - Ghotbeddin, Zohreh
AU  - Ghotbeddin Z
AUID- ORCID: 0000-0003-2110-6333
AD  - Division of Physiology, Department of Basic Sciences, Faculty of Veterinary 
      Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
AD  - Stem Cell and Transgenic Technology Research Center, Shahid Chamran University of 
      Ahvaz, Ahvaz, Iran.
FAU - Tabandeh, Mohammad Reza
AU  - Tabandeh MR
AD  - Stem Cell and Transgenic Technology Research Center, Shahid Chamran University of 
      Ahvaz, Ahvaz, Iran.
AD  - Division of Biochemistry and Molecular Biology, Department of Basic Sciences, 
      Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
FAU - Pourmahdi Borujeni, Mahdi
AU  - Pourmahdi Borujeni M
AD  - Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran 
      University of Ahvaz, Ahvaz, Iran.
FAU - Fahimi Truski, Fahimeh
AU  - Fahimi Truski F
AD  - Division of Physiology, Department of Basic Sciences, Faculty of Veterinary 
      Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
FAU - Zalaki Ghorbani Pour, Mohammad Reza
AU  - Zalaki Ghorbani Pour MR
AD  - Division of Physiology, Department of Basic Sciences, Faculty of Veterinary 
      Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
FAU - Tabrizian, Leila
AU  - Tabrizian L
AD  - Division of Physiology, Department of Basic Sciences, Faculty of Veterinary 
      Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
LA  - eng
SI  - RefSeq/NM_024359
SI  - RefSeq/NM_NM-001034055
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210215
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
RN  - 36-88-4 (Carotenoids)
RN  - 877GWI46C2 (crocin)
RN  - EC 3.4.- (Amyloid Precursor Protein Secretases)
RN  - EC 3.4.23.- (Aspartic Acid Endopeptidases)
SB  - IM
MH  - *Amyloid Precursor Protein Secretases
MH  - Animals
MH  - Animals, Newborn
MH  - Aspartic Acid Endopeptidases/genetics
MH  - Brain
MH  - Carotenoids
MH  - *Cognitive Dysfunction/drug therapy
MH  - Female
MH  - Hypoxia/drug therapy
MH  - Pregnancy
MH  - Rats
PMC - PMC8035433
OTO - NOTNLM
OT  - cognitive behavior
OT  - crocin
OT  - hypoxia
OT  - molecular changes
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/02/16 06:00
MHDA- 2021/07/01 06:00
PMCR- 2021/02/15
CRDT- 2021/02/15 08:48
PHST- 2021/01/16 00:00 [revised]
PHST- 2020/12/02 00:00 [received]
PHST- 2021/01/28 00:00 [accepted]
PHST- 2021/02/16 06:00 [pubmed]
PHST- 2021/07/01 06:00 [medline]
PHST- 2021/02/15 08:48 [entrez]
PHST- 2021/02/15 00:00 [pmc-release]
AID - BRB32078 [pii]
AID - 10.1002/brb3.2078 [doi]
PST - ppublish
SO  - Brain Behav. 2021 Apr;11(4):e02078. doi: 10.1002/brb3.2078. Epub 2021 Feb 15.