PMID- 33588728
OWN - NLM
STAT- MEDLINE
DCOM- 20220510
LR  - 20221012
IS  - 1875-5704 (Electronic)
IS  - 1567-2018 (Linking)
VI  - 19
IP  - 4
DP  - 2022
TI  - Fast Dissolution Electrospun Medicated Nanofibers for Effective Delivery of 
      Poorly Water-Soluble Drug.
PG  - 422-435
LID - 10.2174/1567201818666210215110359 [doi]
AB  - BACKGROUND: Electrospinning is developing rapidly from an earlier laboratory 
      method into an industrial process. The clinical applications of this technique 
      are approached in various ways through electrospun medicated nanofibers. 
      Fast-dissolving oral drug delivery systems (DDSs) have promising commercial 
      applications in the near future. METHODS: Related papers have been investigated 
      in this study, including the latest research results on electrospun 
      nanofiber-based fast-dissolution DDSs. RESULTS: The following related topics are 
      concluded: 1) development of electrospinning, ranging from one-fluid blending to 
      multi-fluid process and potential applications in the formation of medicated 
      nanofibers involving poorly water-soluble drugs; 2) selection of appropriate 
      polymer matrices and drug carriers for filament formation; 3) types of poorly 
      water-soluble drugs ideal for fast oral delivery; 4) methods for evaluating 
      fast-dissolving nanofibers; 5) mechanisms that promote the fast dissolution of 
      poorly water-soluble drugs by electrospun nanofibers; 6) and important issues 
      related to further development of electrospun medicated nanofibers as oral 
      fast-dissolving drug delivery systems. CONCLUSION AND PERSPECTIVE: Given their 
      unique properties, electrospun-medicated nanofibers can be used as oral 
      fast-dissolving DDSs of poorly water-soluble drugs. However, significant issues, 
      such as scalable productions and solid dosage form conversions, need to be 
      investigated.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Aidana, Yrysbaeva
AU  - Aidana Y
AD  - School of Materials Science & Engineering, University of Shanghai for Science & 
      Technology, Shanghai 200093, China.
FAU - Wang, Yibin
AU  - Wang Y
AD  - School of Materials Science & Engineering, University of Shanghai for Science & 
      Technology, Shanghai 200093, China.
FAU - Li, Jie
AU  - Li J
AD  - School of Materials Science & Engineering, University of Shanghai for Science & 
      Technology, Shanghai 200093, China.
FAU - Chang, Shuyue
AU  - Chang S
AD  - School of Materials Science & Engineering, University of Shanghai for Science & 
      Technology, Shanghai 200093, China.
FAU - Wang, Ke
AU  - Wang K
AD  - School of Materials Science & Engineering, University of Shanghai for Science & 
      Technology, Shanghai 200093, China.
FAU - Yu, Deng-Guang
AU  - Yu DG
AD  - School of Materials Science & Engineering, University of Shanghai for Science & 
      Technology, Shanghai 200093, China.
LA  - eng
GR  - 20ZR1439000/Natural Science Foundation of Shanghai/
GR  - XJ2020376-2020378, SH20200227/USST college student innovation projects/
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Drug Deliv
JT  - Current drug delivery
JID - 101208455
RN  - 0 (Drug Carriers)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Drug Carriers
MH  - Drug Delivery Systems
MH  - *Nanofibers
MH  - Solubility
MH  - Water
OTO - NOTNLM
OT  - Electrospinning
OT  - amorphous
OT  - drug delivery system
OT  - electrospun medicated nanofibers
OT  - fast-dissolution
OT  - poorly water-soluble drug
EDAT- 2021/02/17 06:00
MHDA- 2022/05/11 06:00
CRDT- 2021/02/16 05:42
PHST- 2020/10/11 00:00 [received]
PHST- 2020/12/12 00:00 [revised]
PHST- 2020/12/23 00:00 [accepted]
PHST- 2021/02/17 06:00 [pubmed]
PHST- 2022/05/11 06:00 [medline]
PHST- 2021/02/16 05:42 [entrez]
AID - CDD-EPUB-114196 [pii]
AID - 10.2174/1567201818666210215110359 [doi]
PST - ppublish
SO  - Curr Drug Deliv. 2022;19(4):422-435. doi: 10.2174/1567201818666210215110359.