PMID- 33588731
OWN - NLM
STAT- MEDLINE
DCOM- 20220317
LR  - 20221108
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Print)
IS  - 1570-159X (Linking)
VI  - 20
IP  - 3
DP  - 2022 Mar 4
TI  - Glutamate NMDA Receptor Antagonists with Relevance to Schizophrenia: A Review of 
      Zebrafish Behavioral Studies.
PG  - 494-509
LID - 10.2174/1570159X19666210215121428 [doi]
AB  - Schizophrenia pathophysiology is associated with hypofunction of glutamate NMDA 
      receptors (NMDAR) in GABAergic interneurons and dopaminergic hyperactivation in 
      subcortical brain areas. The administration of NMDAR antagonists is used as an 
      animal model that replicates behavioral phenotypes relevant to the positive, 
      negative, and cognitive symptoms of schizophrenia. Such models overwhelmingly 
      rely on rodents, which may lead to species-specific biases and poor 
      translatability. Zebrafish, however, is increasingly used as a model organism to 
      study evolutionarily conserved aspects of behavior. We thus aimed to review and 
      integrate the major findings reported in the zebrafish literature regarding the 
      behavioral effects of NMDAR antagonists with relevance to schizophrenia. We 
      identified 44 research articles that met our inclusion criteria from 590 studies 
      retrieved from MEDLINE (PubMed) and Web of Science databases. Dizocilpine 
      (MK-801) and ketamine were employed in 29 and 10 studies, respectively. The use 
      of other NMDAR antagonists, such as phencyclidine (PCP), APV, memantine, and 
      tiletamine, was described in 6 studies. Frequently reported findings are the 
      social interaction and memory deficits induced by MK-801 and circling behavior 
      induced by ketamine. However, mixed results were described for several locomotor 
      and exploratory parameters in the novel tank and open tank tests. The present 
      review integrates the most relevant results while discussing variation in 
      experimental design and methodological procedures. We conclude that zebrafish is 
      a suitable model organism to study drug-induced behavioral phenotypes relevant to 
      schizophrenia. However, more studies are necessary to further characterize the 
      major differences in behavior as compared to mammals.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Benvenutti, Radharani
AU  - Benvenutti R
AD  - Departamento de Farmacologia, Instituto de Ciencias Basicas da Saude, 
      Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
AD  - Programa de Pos-graduacao em Neurociencias, Instituto de Ciencias Basicas da 
      Saude, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, 
      Brazil.
FAU - Gallas-Lopes, Matheus
AU  - Gallas-Lopes M
AD  - Departamento de Farmacologia, Instituto de Ciencias Basicas da Saude, 
      Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
FAU - Marcon, Matheus
AU  - Marcon M
AD  - Departamento de Farmacologia, Instituto de Ciencias Basicas da Saude, 
      Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
AD  - Programa de Pos-graduacao em Neurociencias, Instituto de Ciencias Basicas da 
      Saude, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, 
      Brazil.
FAU - Reschke, Cristina R
AU  - Reschke CR
AD  - School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in 
      Ireland, Dublin, Ireland.
AD  - FutureNeuro, the SFI Research Centre for Chronic and Rare Neurological Diseases, 
      Royal College of Surgeons in Ireland, Dublin, Ireland.
FAU - Herrmann, Ana Paula
AU  - Herrmann AP
AD  - Departamento de Farmacologia, Instituto de Ciencias Basicas da Saude, 
      Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
AD  - Programa de Pos-graduacao em Farmacologia e Terapeutica, Instituto de Ciencias 
      Basicas da Saude, Universidade Federal do Rio Grande do Sul (UFRGS), Porto 
      Alegre, RS, Brazil.
FAU - Piato, Angelo
AU  - Piato A
AD  - Departamento de Farmacologia, Instituto de Ciencias Basicas da Saude, 
      Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
AD  - Programa de Pos-graduacao em Neurociencias, Instituto de Ciencias Basicas da 
      Saude, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, 
      Brazil.
AD  - Programa de Pos-graduacao em Farmacologia e Terapeutica, Instituto de Ciencias 
      Basicas da Saude, Universidade Federal do Rio Grande do Sul (UFRGS), Porto 
      Alegre, RS, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Dizocilpine Maleate/pharmacology
MH  - *Excitatory Amino Acid Antagonists/pharmacology
MH  - Glutamic Acid
MH  - Mammals
MH  - Receptors, N-Methyl-D-Aspartate
MH  - *Schizophrenia/chemically induced/drug therapy
MH  - Zebrafish
PMC - PMC9608229
OTO - NOTNLM
OT  - MK-801
OT  - PCP
OT  - Schizophrenia
OT  - behavior
OT  - glutamate antagonists
OT  - ketamine
OT  - psychosis
OT  - zebrafish
EDAT- 2021/02/17 06:00
MHDA- 2022/03/18 06:00
PMCR- 2022/09/04
CRDT- 2021/02/16 05:42
PHST- 2020/11/15 00:00 [received]
PHST- 2021/01/29 00:00 [revised]
PHST- 2021/02/04 00:00 [accepted]
PHST- 2021/02/17 06:00 [pubmed]
PHST- 2022/03/18 06:00 [medline]
PHST- 2021/02/16 05:42 [entrez]
PHST- 2022/09/04 00:00 [pmc-release]
AID - CN-EPUB-114206 [pii]
AID - CN-20-494 [pii]
AID - 10.2174/1570159X19666210215121428 [doi]
PST - ppublish
SO  - Curr Neuropharmacol. 2022 Mar 4;20(3):494-509. doi: 
      10.2174/1570159X19666210215121428.