PMID- 33589558
OWN - NLM
STAT- MEDLINE
DCOM- 20211021
LR  - 20211027
IS  - 1499-2752 (Electronic)
IS  - 0315-162X (Linking)
VI  - 48
IP  - 8
DP  - 2021 Aug
TI  - Evaluation and Validation of a Patient-completed Psoriatic Arthritis Flare 
      Questionnaire.
PG  - 1268-1271
LID - 10.3899/jrheum.201317 [doi]
AB  - OBJECTIVE: Evaluation of a psoriatic arthritis (PsA), multidimensional, 
      patient-completed disease flare questionnaire (FLARE). METHODS: The FLARE 
      questionnaire was administered to 139 patients in a prospective observational 
      study. The "gold standard" of flare was based on patient opinion. Test-retest 
      reliability was evaluated by intraclass correlation coefficient (ICC). Disease 
      activity was measured by the Psoriatic Arthritis Disease Activity Score (PASDAS), 
      Group for Research and Assessment of Psoriasis and PsA (GRAPPA) Composite 
      Exercise (GRACE), Composite Psoriatic Disease Activity Index (CPDAI), and Disease 
      Activity Index for Psoriatic Arthritis (DAPSA). RESULTS: The most common symptoms 
      of a PsA flare were musculoskeletal, followed by fatigue, frustration, loss of 
      function, and an increase in cutaneous symptoms. The test-retest ICC for the 
      FLARE questionnaire was 0.87 (95% CI 0.72-0.94). The optimum cut-off to identify 
      a flare of disease was 4/10 (sensitivity 0.82, specificity 0.76; area under the 
      curve 0.85). For those patients scoring >/= 4, the mean score for the composite 
      measures was as follows (score for those not reporting a flare in parentheses): 
      PASDAS 5.3 +/- 1.3 (3.1 +/- 1.6); GRACE 4.5 +/- 1.2 (2.2 +/- 1.4); CPDAI 8.9 +/- 2.5 (4.7 +/- 
      3.1); and DAPSA 38.2 +/- 20.3 (16.8 +/- 14.9). In a new flare, the increase in 
      composite measure score was calculated as follows: 1 for PASDAS and GRACE, 2 for 
      CPDAI, and 7 for DAPSA. Agreement between the definition of flare using the 
      cut-off of 4 from the questionnaire, and that indicated by the subject in a 
      separate, standalone question was 0.57 (Cohen kappa). CONCLUSION: A PsA flare 
      displays escalation of symptoms and signs across multiple domains. The FLARE 
      questionnaire has external validity in terms of both composite disease activity 
      and overall patient opinion about the state of their condition.
CI  - (c) 2021 The Journal of Rheumatology.
FAU - Helliwell, Philip S
AU  - Helliwell PS
AUID- ORCID: 0000-0002-4155-9105
AD  - P.S. Helliwell, Professor of Clinical Rheumatology, MA, DM, PhD, R. Waxman, 
      Research Coordinator, MPH, Leeds Institute of Rheumatic and Musculoskeletal 
      Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds 
      Teaching Hospitals NHS Trust, Leeds, UK; p.helliwell@leeds.ac.uk.
FAU - Tillett, William
AU  - Tillett W
AUID- ORCID: 0000-0001-7531-4125
AD  - W. Tillett, Consultant Rheumatologist, MBChB, PhD, Department of Pharmacy and 
      Pharmacology, University of Bath, and Royal National Hospital for Rheumatic 
      Diseases, Royal United Hospitals, Bath, UK.
FAU - Waxman, Robin
AU  - Waxman R
AD  - P.S. Helliwell, Professor of Clinical Rheumatology, MA, DM, PhD, R. Waxman, 
      Research Coordinator, MPH, Leeds Institute of Rheumatic and Musculoskeletal 
      Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds 
      Teaching Hospitals NHS Trust, Leeds, UK.
FAU - Coates, Laura C
AU  - Coates LC
AUID- ORCID: 0000-0002-4756-663X
AD  - L.C. Coates, NIHR Clinician Scientist and Associate Professor, MBChB, PhD, 
      Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, 
      University of Oxford, Oxford, UK.
FAU - Brooke, Mel
AU  - Brooke M
AD  - M. Brooke, Patient Partner.
FAU - FitzGerald, Oliver
AU  - FitzGerald O
AUID- ORCID: 0000-0002-6607-6070
AD  - O. FitzGerald, Consultant Rheumatologist, MD, Conway Institute for Biomolecular 
      Research, University College Dublin, Dublin, Ireland.
FAU - Packham, Jonathan C
AU  - Packham JC
AD  - J.C. Packham, Consultant Rheumatologist, BM, FRCP, DM, Division of Epidemiology 
      and Public of Health, University of Nottingham, Nottingham, UK.
FAU - McHugh, Neil
AU  - McHugh N
AUID- ORCID: 0000-0003-2765-658X
CN  - PROMPT Study Group
LA  - eng
GR  - RP-PG-1212-20007/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20210215
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
SB  - IM
MH  - *Arthritis, Psoriatic/diagnosis
MH  - Humans
MH  - *Psoriasis
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - outcome measures
OT  - psoriasis
OT  - psoriatic arthritis
EDAT- 2021/02/17 06:00
MHDA- 2021/10/28 06:00
CRDT- 2021/02/16 06:02
PHST- 2021/02/02 00:00 [accepted]
PHST- 2021/02/17 06:00 [pubmed]
PHST- 2021/10/28 06:00 [medline]
PHST- 2021/02/16 06:02 [entrez]
AID - jrheum.201317 [pii]
AID - 10.3899/jrheum.201317 [doi]
PST - ppublish
SO  - J Rheumatol. 2021 Aug;48(8):1268-1271. doi: 10.3899/jrheum.201317. Epub 2021 Feb 
      15.