PMID- 33590892
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20211214
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 93
IP  - 8
DP  - 2021 Aug
TI  - Changes in peripheral blood cytokines in patients with severe fever with 
      thrombocytopenia syndrome.
PG  - 4704-4713
LID - 10.1002/jmv.26877 [doi]
AB  - Severe fever with thrombocytopenia syndrome (SFTS) is recognized as an emerging 
      infectious disease. This study aimed to investigate the pathogenic mechanism of 
      SFTS. A total of 100 subjects were randomly included in the study. Cytokine 
      levels were detected by enzyme-linked immunosorbent assay and the viral load was 
      detected by micro drop digital PCR. The results showed that levels of 
      interleukin-6 (IL-6), IL-8, IL-10, IFN-inducible protein-10 (IP-10), monocyte 
      chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha), 
      transforming growth factor-beta1 (TGF-beta1), and regulated upon activation normal T 
      cell expressed and secreted factor (RANTES) differed significantly among the SFTS 
      patient group, healthy people group, and asymptomatic infection group (p < .05). 
      Compared to the healthy people group, the patient group had increased cytokine 
      levels (IL-6, IL-10, IP-10, MCP-1, and IFN-gamma) but reduced levels of IL-8, TGF-beta1, 
      and RANTES (p < .0167). IL-6, IL-8, IL-10, IP-10, MCP-1, MIP-1alpha, TGF-beta1, and the 
      RANTES levels had different trends after the onset of the disease. IL-6, IL-10, 
      IP-10, and MCP-1 levels in severe patients were higher than those in mild 
      patients (p < .05). There was a positive correlation between viral load and IL-6 
      and IP-10 but a negative correlation between viral load and RANTES. SFTSV could 
      cause a cytokine change: the cytokine levels of patients had different degrees of 
      fluctuation after the onset of the disease. The levels of IL-6 and IL-8 in the 
      asymptomatic infection group were found between the SFTS patients group and the 
      healthy people group. The levels of IL-6, IL-10, IP-10, and MCP-1 in the serum 
      could reflect the severity of the disease, and the levels of IL-6, IP-10, and 
      RANTES were correlated with the viral load.
CI  - (c) 2021 The Authors. Journal of Medical Virology Published by Wiley Periodicals 
      LLC.
FAU - He, Zhiquan
AU  - He Z
AD  - Department of Infectious Disease Control and Prevention, Henan Province Center 
      for Disease Control and Prevention, Zhengzhou, China.
FAU - Wang, Bohao
AU  - Wang B
AD  - College of Public Health, Zhengzhou University, Zhengzhou, China.
FAU - Li, Yi
AU  - Li Y
AD  - Department of Infectious Disease Control and Prevention, Henan Province Center 
      for Disease Control and Prevention, Zhengzhou, China.
AD  - Henan Key Laboratory of Pathogenic Microorganisms, Henan Province Center for 
      Disease Control and Prevention, Zhengzhou, China.
FAU - Hu, Kai
AU  - Hu K
AD  - Health Policy Research Center, Henan Academy of Medical Sciences, Zhengzhou, 
      China.
FAU - Yi, Zhijie
AU  - Yi Z
AD  - College of Public Health, Zhengzhou University, Zhengzhou, China.
FAU - Ma, Hongxia
AU  - Ma H
AD  - Department of Infectious Disease Control and Prevention, Henan Province Center 
      for Disease Control and Prevention, Zhengzhou, China.
AD  - Henan Key Laboratory of Pathogenic Microorganisms, Henan Province Center for 
      Disease Control and Prevention, Zhengzhou, China.
FAU - Li, Xingle
AU  - Li X
AD  - Department of Infectious Disease Control and Prevention, Henan Province Center 
      for Disease Control and Prevention, Zhengzhou, China.
AD  - Henan Key Laboratory of Pathogenic Microorganisms, Henan Province Center for 
      Disease Control and Prevention, Zhengzhou, China.
FAU - Guo, Wanshen
AU  - Guo W
AD  - Department of Infectious Disease Control and Prevention, Henan Province Center 
      for Disease Control and Prevention, Zhengzhou, China.
FAU - Xu, Bianli
AU  - Xu B
AD  - Department of Infectious Disease Control and Prevention, Henan Province Center 
      for Disease Control and Prevention, Zhengzhou, China.
FAU - Huang, Xueyong
AU  - Huang X
AUID- ORCID: 0000-0001-8995-9274
AD  - Department of Infectious Disease Control and Prevention, Henan Province Center 
      for Disease Control and Prevention, Zhengzhou, China.
AD  - Henan Key Laboratory of Pathogenic Microorganisms, Henan Province Center for 
      Disease Control and Prevention, Zhengzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210311
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Cytokines)
SB  - IM
MH  - Aged
MH  - Cytokines/*blood/classification/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phlebovirus/classification/*immunology
MH  - Severe Fever with Thrombocytopenia Syndrome/*blood/*immunology/physiopathology
MH  - Severity of Illness Index
MH  - Viral Load
PMC - PMC8360139
OTO - NOTNLM
OT  - asymptomatic infected persons
OT  - cytokines
OT  - patients
OT  - severe fever with thrombocytopenia syndrome
OT  - viral load
COIS- The authors declare that there are no conflict of interests.
EDAT- 2021/02/17 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/08/12
CRDT- 2021/02/16 08:37
PHST- 2021/02/03 00:00 [revised]
PHST- 2020/09/21 00:00 [received]
PHST- 2021/02/12 00:00 [accepted]
PHST- 2021/02/17 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/02/16 08:37 [entrez]
PHST- 2021/08/12 00:00 [pmc-release]
AID - JMV26877 [pii]
AID - 10.1002/jmv.26877 [doi]
PST - ppublish
SO  - J Med Virol. 2021 Aug;93(8):4704-4713. doi: 10.1002/jmv.26877. Epub 2021 Mar 11.