PMID- 33591429
OWN - NLM
STAT- MEDLINE
DCOM- 20211123
LR  - 20211123
IS  - 1435-5922 (Electronic)
IS  - 0944-1174 (Linking)
VI  - 56
IP  - 5
DP  - 2021 May
TI  - Classification of patients with esophageal eosinophilia by patterns of 
      sensitization revealed by a diagnostic assay for multiple allergen-specific IgEs.
PG  - 422-433
LID - 10.1007/s00535-021-01766-3 [doi]
AB  - BACKGROUND: Eosinophilic esophagitis (EoE) is considered to be an immunoglobulin 
      E (IgE)-mediated allergic disorder. Our goal was to examine IgE-mediated allergic 
      sensitization patterns in patients with esophageal eosinophilia (EE). METHODS: We 
      enrolled subjects with EE who underwent evaluation with a diagnostic panel to 
      document multiple allergen-specific IgEs. Statistically significant groups were 
      identified by cluster analysis. We also defined allergens based on their 
      characteristics including outdoor, indoor, plant, and animal allergens. RESULTS: 
      We classified patients with EE into 3 distinct groups, including cluster 1 
      (n = 62) who were minimally sensitized to most allergens except pollen and house 
      dust, cluster 2 (n = 30) who were hypersensitized to outdoor and plant allergens, 
      and cluster 3 (n = 15) who were hypersensitized to most allergens, most notably 
      to indoor and animal allergens. Dysphagia reported among those in clusters 1, 2, 
      and 3 at 35.5%, 46.7%, and 73.3%, respectively, (p = 0.028) and EoE endoscopic 
      reference scores (EREFS) at 3.0, 6.0, and 8.0, respectively, (p < 0.001) differed 
      significantly between the 3 clusters. Those in cluster 3 had a significantly 
      higher prevalence of dysphagia (35.5% vs. 73.3%, p = 0.030), and higher EREFS 
      with respect to rings (0.3 vs. 0.9, p = 0.003) and strictures (0.0 vs. 0.13, 
      p = 0.011) compared to those in cluster 1. CONCLUSIONS: IgE-mediated allergic 
      sensitization patterns are associated with clinical features of patients with EE. 
      Use of a diagnostic panel that detects multiple allergen-specific IgEs can help 
      to explain the heterogeneous phenotype of this patient cohort.
FAU - Nakata, Akinobu
AU  - Nakata A
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Tanaka, Fumio
AU  - Tanaka F
AUID- ORCID: 0000-0002-9186-1249
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan. 
      m2079981@med.osaka-cu.ac.jp.
FAU - Nadatani, Yuji
AU  - Nadatani Y
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Fukunaga, Shusei
AU  - Fukunaga S
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Otani, Koji
AU  - Otani K
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Hosomi, Shuhei
AU  - Hosomi S
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Kamata, Noriko
AU  - Kamata N
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Taira, Koichi
AU  - Taira K
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Nagami, Yasuaki
AU  - Nagami Y
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Watanabe, Toshio
AU  - Watanabe T
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Fujiwara, Yasuhiro
AU  - Fujiwara Y
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210216
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
SB  - IM
MH  - Adult
MH  - Eosinophilic Esophagitis/*classification/*immunology/physiopathology
MH  - Female
MH  - Humans
MH  - Immunization/methods/statistics & numerical data
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
OTO - NOTNLM
OT  - Allergens
OT  - Diagnostic panel
OT  - Eosinophilic esophagitis
OT  - Immunoglobulin E
OT  - Sensitization patterns
EDAT- 2021/02/17 06:00
MHDA- 2021/11/24 06:00
CRDT- 2021/02/16 12:11
PHST- 2020/06/18 00:00 [received]
PHST- 2021/01/25 00:00 [accepted]
PHST- 2021/02/17 06:00 [pubmed]
PHST- 2021/11/24 06:00 [medline]
PHST- 2021/02/16 12:11 [entrez]
AID - 10.1007/s00535-021-01766-3 [pii]
AID - 10.1007/s00535-021-01766-3 [doi]
PST - ppublish
SO  - J Gastroenterol. 2021 May;56(5):422-433. doi: 10.1007/s00535-021-01766-3. Epub 
      2021 Feb 16.