PMID- 33592238
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 330
DP  - 2021 May 1
TI  - Cardiac conduction abnormalities in patients with degenerated bioprostheses 
      undergoing transcatheter aortic valve-in-valve implantations and their impact on 
      long-term outcomes.
PG  - 16-22
LID - S0167-5273(21)00282-5 [pii]
LID - 10.1016/j.ijcard.2021.02.029 [doi]
AB  - BACKGROUND: The relationship between preoperative cardiac conduction 
      abnormalities (CCA) and long-term outcomes after transcatheter aortic 
      valve-in-valve implantation (TAVI-VIV) remains unclear. The aim of the study was 
      to evaluate the effects of preoperative CCA on mortality and morbidity after 
      TAVI-VIV and to estimate the impact of new-onset CCA on postoperative outcomes. 
      METHODS: Between 2011 and 2020, 201 patients with degenerated aortic 
      bioprostheses were qualified for TAVI-VIV procedures in two German heart centers. 
      Cases with previously implanted permanent rhythm-controlling devices were 
      excluded (n = 53). A total of 148 subjects met the eligibility criteria and were 
      divided into 2 study groups according to the presence of preexisting CCA (CCA 
      (n = 84) and non-CCA (n = 64), respectively). Early and late mortality and 
      morbidity were evaluated. Follow-up functional status was assessed according to 
      New York Heart Association (NYHA) classification. RESULTS: There were no 
      procedural deaths. TAVI-VIV related new-onset CCAs were observed in 35.8% 
      patients. The 30-day permanent pacemaker implantation rate was 1.6% in non-CCA vs 
      9.5% in CCA group (p = 0.045). Preexisting right bundle-branch block (OR:5.01; 
      95%CI, 1.05-23.84) and first-degree atrioventricular block (OR:4.55; 95%CI, 
      1.10-18.73) were independent predictors of new pacemaker implantation. One-year 
      and five-year probability of survival were comparable in CCA and non-CCA groups: 
      90.3% vs 91.8% and 68.2% vs 74.3%, respectively. Surviving patients with 
      preexisting and new-onset CCA had a worse functional status according to NYHA 
      classification at follow-up. CONCLUSION: Preexisting and new-onset postoperative 
      CCAs did not affect early and late mortality after TAVI-VIV procedures, however, 
      they may have a negative impact on late functional status.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Stankowski, Tomasz
AU  - Stankowski T
AD  - Sana Heart Center Cottbus, Department of Cardiac Surgery, Cottbus, Germany. 
      Electronic address: tomekstankowski89@gmail.com.
FAU - Mangner, Norman
AU  - Mangner N
AD  - Herzzentrum Dresden, Technische Universitat Dresden, Department of Internal 
      Medicine and Cardiology, Dresden, Germany.
FAU - Linke, Axel
AU  - Linke A
AD  - Herzzentrum Dresden, Technische Universitat Dresden, Department of Internal 
      Medicine and Cardiology, Dresden, Germany.
FAU - Aboul-Hassan, Sleiman Sebastian
AU  - Aboul-Hassan SS
AD  - Department of Cardiac Surgery, Medinet Heart Center Ltd., Nowa Sol, Poland.
FAU - Gasior, Tomasz
AU  - Gasior T
AD  - Herzzentrum Dresden, Technische Universitat Dresden, Department of Internal 
      Medicine and Cardiology, Dresden, Germany.
FAU - Muehle, Anja
AU  - Muehle A
AD  - Sana Heart Center Cottbus, Department of Cardiac Surgery, Cottbus, Germany.
FAU - Herwig, Volker
AU  - Herwig V
AD  - Sana Heart Center Cottbus, Department of Cardiac Surgery, Cottbus, Germany.
FAU - Harnath, Axel
AU  - Harnath A
AD  - Sana Heart Center Cottbus, Department of Cardiac Surgery, Cottbus, Germany.
FAU - Salem, Mohammed
AU  - Salem M
AD  - Department of Cardiology, Carl-Thiem-Klinikum, Cottbus, Germany.
FAU - Szlapka, Michal
AU  - Szlapka M
AD  - Department of Cardiac Surgery, Asklepios Klinik Harburg, Hamburg, Germany.
FAU - Grimmig, Oliver
AU  - Grimmig O
AD  - Sana Heart Center Cottbus, Department of Cardiac Surgery, Cottbus, Germany.
FAU - Just, Soeren
AU  - Just S
AD  - Sana Heart Center Cottbus, Department of Cardiac Surgery, Cottbus, Germany.
FAU - Fritzsche, Dirk
AU  - Fritzsche D
AD  - Sana Heart Center Cottbus, Department of Cardiac Surgery, Cottbus, Germany.
FAU - Perek, Bartlomiej
AU  - Perek B
AD  - Department of Cardiac Surgery and Transplantology, Poznan University of Medical 
      Sciences, Poznan, Poland.
LA  - eng
PT  - Journal Article
DEP - 20210214
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
CIN - Int J Cardiol. 2021 Jun 1;332:157-158. PMID: 33746050
MH  - Aortic Valve/diagnostic imaging/surgery
MH  - *Aortic Valve Stenosis/diagnostic imaging/surgery
MH  - *Bioprosthesis/adverse effects
MH  - *Heart Valve Prosthesis/adverse effects
MH  - Humans
MH  - *Transcatheter Aortic Valve Replacement/adverse effects
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Aortic valve
OT  - Conduction disturbances
OT  - Degenerated bioprosthesis
OT  - Outcomes
OT  - Transcatheter aortic valve-in-valve implantation
EDAT- 2021/02/17 06:00
MHDA- 2021/05/29 06:00
CRDT- 2021/02/16 20:09
PHST- 2020/12/14 00:00 [received]
PHST- 2021/02/08 00:00 [revised]
PHST- 2021/02/10 00:00 [accepted]
PHST- 2021/02/17 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2021/02/16 20:09 [entrez]
AID - S0167-5273(21)00282-5 [pii]
AID - 10.1016/j.ijcard.2021.02.029 [doi]
PST - ppublish
SO  - Int J Cardiol. 2021 May 1;330:16-22. doi: 10.1016/j.ijcard.2021.02.029. Epub 2021 
      Feb 14.