PMID- 33592327
OWN - NLM
STAT- MEDLINE
DCOM- 20210708
LR  - 20211204
IS  - 1873-2763 (Electronic)
IS  - 1873-2763 (Linking)
VI  - 146
DP  - 2021 May
TI  - Magnesium supplementation enhances mTOR signalling to facilitate myogenic 
      differentiation and improve aged muscle performance.
PG  - 115886
LID - S8756-3282(21)00048-X [pii]
LID - 10.1016/j.bone.2021.115886 [doi]
AB  - Magnesium (Mg(2+)), as an essential mineral, supports and sustains the health and 
      activity of the organs of the human body. Despite some clinical evidence on the 
      association of Mg(2+) deficiency with muscle regeneration dysfunction and 
      sarcopenia in older-aged individuals, there is no consensus on the action mode 
      and molecular mechanism by which Mg(2+) influences aged muscle size and function. 
      Here, we identified the appropriate Mg(2+) environment that promotes the myogenic 
      differentiation and myotube hypertrophy in both C2C12 myoblast and primary aged 
      muscle stem cell (MuSC). Through animal experiments, we demonstrated that Mg(2+) 
      supplementation in aged mice significantly promotes muscle regeneration and 
      conserves muscle mass and strength. Mechanistically, Mg(2+) stimulation activated 
      the mammalian target of rapamycin (mTOR) signalling, inducing the myogenic 
      differentiation and protein synthesis, which consequently offers protections 
      against the age-related decline in muscle regenerative potential and muscle mass. 
      These findings collectively provide a promising therapeutic strategy for MuSC 
      dysfunction and sarcopenia through Mg(2+) supplementation in the elderly.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Liu, Yuantong
AU  - Liu Y
AD  - Department of Spine Surgery, Shenzhen People's Hospital, The Second Clinical 
      Medical College, Jinan University, Shenzhen 518020, China; The First Affiliated 
      Hospital, Jinan University, Guangzhou 510630, China.
FAU - Wang, Qinghe
AU  - Wang Q
AD  - Department of Spine Surgery, Shenzhen People's Hospital, The Second Clinical 
      Medical College, Jinan University, Shenzhen 518020, China.
FAU - Zhang, Zengfu
AU  - Zhang Z
AD  - School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan 
      250012, China.
FAU - Fu, Runhan
AU  - Fu R
AD  - School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan 
      250012, China.
FAU - Zhou, Tianjian
AU  - Zhou T
AD  - Shenzhen Key Laboratory of Tissue and Functional Reconstruction of Sports System, 
      The First Affiliated Hospital of Southern University of Science and Technology, 
      Shenzhen 518020, China.
FAU - Long, Canling
AU  - Long C
AD  - Department of Spine Surgery, Shenzhen People's Hospital, The Second Clinical 
      Medical College, Jinan University, Shenzhen 518020, China.
FAU - He, Tongzhong
AU  - He T
AD  - Department of Spine Surgery, Shenzhen People's Hospital, The Second Clinical 
      Medical College, Jinan University, Shenzhen 518020, China.
FAU - Yang, Dazhi
AU  - Yang D
AD  - Department of Spine Surgery, Shenzhen People's Hospital, The Second Clinical 
      Medical College, Jinan University, Shenzhen 518020, China. Electronic address: 
      yangdazhi1111@163.com.
FAU - Li, Zhizhong
AU  - Li Z
AD  - The First Affiliated Hospital, Jinan University, Guangzhou 510630, China. 
      Electronic address: lizhizhongjd@163.com.
FAU - Peng, Songlin
AU  - Peng S
AD  - Department of Spine Surgery, Shenzhen People's Hospital, The Second Clinical 
      Medical College, Jinan University, Shenzhen 518020, China; Shenzhen Key 
      Laboratory of Tissue and Functional Reconstruction of Sports System, The First 
      Affiliated Hospital of Southern University of Science and Technology, Shenzhen 
      518020, China. Electronic address: songlin824@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210214
PL  - United States
TA  - Bone
JT  - Bone
JID - 8504048
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Dietary Supplements
MH  - *Magnesium/pharmacology
MH  - Mice
MH  - *Muscle Development
MH  - Muscle, Skeletal
MH  - TOR Serine-Threonine Kinases
OTO - NOTNLM
OT  - Aging
OT  - Magnesium
OT  - Muscle regeneration
OT  - Muscle stem cell
OT  - Myogenic differentiation
OT  - Sarcopenia
EDAT- 2021/02/17 06:00
MHDA- 2021/07/09 06:00
CRDT- 2021/02/16 20:09
PHST- 2020/11/03 00:00 [received]
PHST- 2021/01/08 00:00 [revised]
PHST- 2021/02/09 00:00 [accepted]
PHST- 2021/02/17 06:00 [pubmed]
PHST- 2021/07/09 06:00 [medline]
PHST- 2021/02/16 20:09 [entrez]
AID - S8756-3282(21)00048-X [pii]
AID - 10.1016/j.bone.2021.115886 [doi]
PST - ppublish
SO  - Bone. 2021 May;146:115886. doi: 10.1016/j.bone.2021.115886. Epub 2021 Feb 14.