PMID- 33593406
OWN - NLM
STAT- MEDLINE
DCOM- 20210825
LR  - 20210825
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Print)
IS  - 1364-8535 (Linking)
VI  - 25
IP  - 1
DP  - 2021 Feb 16
TI  - Prevalence of post-intensive care syndrome among Japanese intensive care unit 
      patients: a prospective, multicenter, observational J-PICS study.
PG  - 69
LID - 10.1186/s13054-021-03501-z [doi]
LID - 69
AB  - BACKGROUND: Many studies have compared quality of life of post-intensive care 
      syndrome (PICS) patients with age-matched population-based controls. Many studies 
      on PICS used the 36-item Short Form (SF-36) health survey questionnaire version 
      2, but lack the data for SF-36 values before and after intensive care unit (ICU) 
      admission. Thus, clinically important changes in the parameters of SF-36 are 
      unknown. Therefore, we determined the frequency of co-occurrence of PICS 
      impairments at 6 months after ICU admission. We also evaluated the changes in 
      SF-36 subscales and interpreted the patients' subjective significance of 
      impairment. METHODS: A prospective, multicenter, observational cohort study was 
      conducted in 16 ICUs across 14 hospitals in Japan. Adult ICU patients expected to 
      receive mechanical ventilation for > 48 h were enrolled, and their 6-month 
      outcome was assessed using the questionnaires. PICS definition was based on the 
      physical status, indicated by the change in SF-36 physical component score 
      (PCS) >/= 10 points; mental status, indicated by the change in SF-36 mental 
      component score (MCS) >/= 10 points; and cognitive function, indicated by the 
      worsening of Short-Memory Questionnaire (SMQ) score and SMQ score at 
      6 months < 40. Multivariate logistic regression model was used to identify the 
      factors associated with PICS occurrence. The patients' subjective significance of 
      physical and mental symptoms was assessed using the 7-scale Global Assessment 
      Rating to evaluate minimal clinically important difference (MCID). RESULTS: Among 
      192 patients, 48 (25%) died at 6 months. Among the survivors at 6 months, 96 
      patients responded to the questionnaire; >/= 1 PICS impairment occurred in 61 
      (63.5%) patients, and >/= 2 occurred in 17 (17.8%) patients. Physical, mental, and 
      cognitive impairments occurred in 32.3%, 14.6% and 37.5% patients, respectively. 
      Population with only mandatory education was associated with PICS occurrence 
      (odds ratio: 4.0, 95% CI 1.1-18.8, P = 0.029). The MCID of PCS and MCS scores was 
      6.5 and 8.0, respectively. CONCLUSIONS: Among the survivors who received 
      mechanical ventilation, 64% had PICS at 6 months; co-occurrence of PICS 
      impairments occurred in 20%. PICS was associated with population with only 
      mandatory education. Future studies elucidating the MCID of SF-36 scores among 
      ICU patients and standardizing the PICS definition are required. Trial 
      registration UMIN000034072.
FAU - Kawakami, Daisuke
AU  - Kawakami D
AUID- ORCID: 0000-0001-7325-5512
AD  - Department of Anesthesia and Critical Care, Kobe City Medical Center General 
      Hospital, 2-1-1, Minatojima minamimachi, Chuo-ku, Kobe-City, Hyogo Prefecture, 
      650-0047, Japan. dsk_kwkm_n9s@hotmail.co.jp.
FAU - Fujitani, Shigeki
AU  - Fujitani S
AD  - Department of Emergency and Critical Care Medicine, St. Marianna University 
      School of Medicine, Kawasaki, Kanagawa Prefecture, 216-8511, Japan.
FAU - Morimoto, Takeshi
AU  - Morimoto T
AD  - Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, 
      Hyogo Prefecture, 663-8501, Japan.
FAU - Dote, Hisashi
AU  - Dote H
AD  - Department of Emergency and Critical Care Medicine, Seirei Hamamatsu General 
      Hospital, Hamamatsu, Shizuoka Prefecture, 430-8558, Japan.
FAU - Takita, Mumon
AU  - Takita M
AD  - Department of Emergency and Critical Care Medicine, St. Marianna University 
      School of Medicine, Kawasaki, Kanagawa Prefecture, 216-8511, Japan.
FAU - Takaba, Akihiro
AU  - Takaba A
AD  - Department of Emergency and Critical Care Medicine, Hiroshima General Hospital, 
      Hatsukaichi, JAHisoshima Prefecture, 738-8503, Japan.
FAU - Hino, Masaaki
AU  - Hino M
AD  - Emergency and Critical Care Center, Kurashiki Central Hospital, Kurashiki, 
      Okayama Prefecture, 710-8602, Japan.
FAU - Nakamura, Michitaka
AU  - Nakamura M
AD  - Department of Critical Care Medicine, Nara Prefecture General Medical Center, 
      Nara, Nara Prefecture, 630-8581, Japan.
FAU - Irie, Hiromasa
AU  - Irie H
AD  - Department of Anesthesiology, Kurashiki Central Hospital, Kurashiki, Okayama 
      Prefecture, 710-8602, Japan.
FAU - Adachi, Tomohiro
AU  - Adachi T
AD  - Emergency and Critical Care Center, Tokyo Women's Medical University Medical 
      Center East, Tokyo, 116-8567, Japan.
FAU - Shibata, Mami
AU  - Shibata M
AD  - Department of Emergency and Critical Care Medicine, Wakayama Medical University, 
      Wakayama, Wakayama Prefecture, 641-8510, Japan.
FAU - Kataoka, Jun
AU  - Kataoka J
AD  - Department of Critical Care Medicine, Tokyo Bay Urayasu Ichikawa Medical Center, 
      Urayasu, Chiba, 279-0001, Japan.
FAU - Korenaga, Akira
AU  - Korenaga A
AD  - Department of Emergency Medicine, Japanese Red Cross Wakayama Medical Center, 
      Wakayama, Wakayama Prefecture, 640-8558, Japan.
FAU - Yamashita, Tomoya
AU  - Yamashita T
AD  - Department of Emergency and Critical Care, Osaka City General Hospital, Osaka, 
      534-0021, Japan.
FAU - Okazaki, Tomoya
AU  - Okazaki T
AD  - Emergency Medical Center, Kagawa University Hospital, Kita, Kagawa Prefecture, 
      761-0793, Japan.
FAU - Okumura, Masatoshi
AU  - Okumura M
AD  - Department of Anesthesiology, Aichi Medical University Hospital, Nagakute, Aichi 
      Prefecture, 480-1195, Japan.
FAU - Tsunemitsu, Takefumi
AU  - Tsunemitsu T
AD  - Department of Emergency Medicine, Hyogo Prefectural Amagasaki General Medical 
      Center, Hyogo Prefecture, Amagasaki, 660-8550, Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20210216
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
RN  - postintensive care syndrome
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Critical Illness/epidemiology/*psychology
MH  - Female
MH  - Humans
MH  - Intensive Care Units/organization & administration/statistics & numerical data
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Quality of Life/psychology
MH  - Surveys and Questionnaires
MH  - Survivors/psychology
PMC - PMC7888178
OTO - NOTNLM
OT  - Critical care
OT  - Disability
OT  - Health-related quality of life
OT  - Intensive care unit
OT  - Mechanical ventilation
OT  - Post-intensive care syndrome
OT  - SF-36
COIS- The authors declare that they have no competing interests.
EDAT- 2021/02/18 06:00
MHDA- 2021/08/26 06:00
PMCR- 2021/02/16
CRDT- 2021/02/17 05:39
PHST- 2020/09/16 00:00 [received]
PHST- 2021/02/10 00:00 [accepted]
PHST- 2021/02/17 05:39 [entrez]
PHST- 2021/02/18 06:00 [pubmed]
PHST- 2021/08/26 06:00 [medline]
PHST- 2021/02/16 00:00 [pmc-release]
AID - 10.1186/s13054-021-03501-z [pii]
AID - 3501 [pii]
AID - 10.1186/s13054-021-03501-z [doi]
PST - epublish
SO  - Crit Care. 2021 Feb 16;25(1):69. doi: 10.1186/s13054-021-03501-z.