PMID- 33593542
OWN - NLM
STAT- MEDLINE
DCOM- 20210521
LR  - 20210521
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 258
DP  - 2021 Apr 15
TI  - Developments on carboxymethyl starch-based smart systems as promising drug 
      carriers: A review.
PG  - 117654
LID - S0144-8617(21)00042-4 [pii]
LID - 10.1016/j.carbpol.2021.117654 [doi]
AB  - Conventional drug administrations are associated with low bioavailability, high 
      cost, more side effects, uncontrolled release profile, and patient noncompliance. 
      Therefore, the development of an alternative to traditional drug delivery systems 
      (DDSs) is of crucial significance. Up to now, various materials have been 
      investigated for these purposes, among them, carboxymethyl starch (CMS) owing to 
      its specific advantages has been studied for extensively drug delivery, 
      particularly for oral administration. This review for the first time provides an 
      outline of the CMS application in all areas of drug delivery. Thus, the major 
      focus of this review is the detailed highlighting of the recent advances in CMS 
      based DDSs to offer comprehensive information for overcoming traditional DDSs. 
      The perspectives and the challenges of the CMS-based DDSs are briefly commented 
      as well as. Hopefully, the current review will help to promotion of new 
      innovative types of CMS-based systems for drug delivery applications in the near 
      future.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Pooresmaeil, Malihe
AU  - Pooresmaeil M
AD  - Research Laboratory of Dendrimers and Natural Polymers, Faculty of Chemistry, 
      University of Tabriz, P.O. Box 5166616471, Tabriz, Iran. Electronic address: 
      malihepooresmael@yahoo.com.
FAU - Namazi, Hassan
AU  - Namazi H
AD  - Research Laboratory of Dendrimers and Natural Polymers, Faculty of Chemistry, 
      University of Tabriz, P.O. Box 5166616471, Tabriz, Iran; Research Center for 
      Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Science, 
      Tabriz, Iran. Electronic address: namazi@tabrizu.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210119
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Biocompatible Materials)
RN  - 0 (Drug Carriers)
RN  - 0 (Inorganic Chemicals)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Polymers)
RN  - 0 (Tablets)
RN  - 059QF0KO0R (Water)
RN  - 9005-25-8 (Starch)
RN  - 9057-06-1 (carboxymethyl starch)
SB  - IM
MH  - *Administration, Oral
MH  - Biocompatible Materials/chemistry
MH  - Biological Availability
MH  - Chemistry, Pharmaceutical/methods/*trends
MH  - *Drug Carriers
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Inorganic Chemicals
MH  - Nanoparticles/chemistry
MH  - Pharmaceutical Preparations
MH  - Polymers/chemistry
MH  - Solubility
MH  - Starch/*analogs & derivatives/chemistry
MH  - Tablets
MH  - Water/chemistry
OTO - NOTNLM
OT  - 5-Aminosalicylic acid (PubChem CID: 201587)
OT  - Amylopectin (PubChem CID: 439207)
OT  - Amylose (PubChem CID: 53477771)
OT  - Biomaterials
OT  - Carboxy methyl starch (PubChem CID: 376058277)
OT  - Carboxymethyl starch
OT  - Chitosan (PubChem CID: 71853)
OT  - Diclofenac sodium (PubChem CID: 5018304)
OT  - Doxorubicin (PubChem CID: 31703)
OT  - Drug delivery
OT  - Glucose (PubChem CID: 107526)
OT  - Hydrophilicity
OT  - Ibuprofen (PubChem CID: 3672)
OT  - Insulin (PubChem CID: 16132438)
OT  - Monochloroacetic Acid (PubChem CID: 300)
OT  - Starch (PubChem CID: 145864875)
EDAT- 2021/02/18 06:00
MHDA- 2021/05/22 06:00
CRDT- 2021/02/17 05:41
PHST- 2020/10/21 00:00 [received]
PHST- 2021/01/06 00:00 [revised]
PHST- 2021/01/11 00:00 [accepted]
PHST- 2021/02/17 05:41 [entrez]
PHST- 2021/02/18 06:00 [pubmed]
PHST- 2021/05/22 06:00 [medline]
AID - S0144-8617(21)00042-4 [pii]
AID - 10.1016/j.carbpol.2021.117654 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2021 Apr 15;258:117654. doi: 10.1016/j.carbpol.2021.117654. Epub 
      2021 Jan 19.