PMID- 33594542
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20210623
IS  - 1432-1076 (Electronic)
IS  - 0340-6199 (Linking)
VI  - 180
IP  - 7
DP  - 2021 Jul
TI  - Permanent childhood hearing impairment in infants admitted to the neonatal 
      intensive care unit: nested case-control study.
PG  - 2083-2089
LID - 10.1007/s00431-021-03983-7 [doi]
AB  - The prevalence of permanent childhood hearing impairment (PCHI) in infants 
      admitted to a neonatal intensive care unit (NICU) is higher than that in the 
      general population. Our study objective was to identify risk factors associated 
      with PCHI in infants who required admission to the NICU for more than 48 h. We 
      performed a case-control study, including infants of all gestational ages who 
      were admitted to NICU for more than 48 h and who underwent newborn hearing 
      screening between 2005 and 2019. Infants admitted to NICU and diagnosed with PCHI 
      by formal audiology were classified as "cases". The "controls" were infants who 
      were admitted to NICU and did not have PCHI. Cases and controls (1:4) were 
      matched based on their birth gestation, birthing place, and treating NICU. The 
      prevalence of PCHI in infants admitted to NICU was 6.3% as compared with our 
      general population prevalence of 0.25%. There were 77 cases and 269 controls 
      during the study period. The median age at diagnosis of PCHI in these infants was 
      132 days (interquartile range 75.5-518.5). Using regression analysis, "any 
      ventilation episodes", presence of seizures, and major congenital anomalies were 
      significantly associated with PCHI in infants of all gestational ages. There were 
      higher prevalence of PCHI in preterms (<32 weeks) who received furosemide and 
      lower prevalence with antenatal use of magnesium sulphate.Conclusions: In our 
      study, the prevalence of hearing loss was high in infants admitted to NICU. 
      Gestation-specific risk factors identified in this case-control study would help 
      in counselling of parents. What is Known: * In the UK, 1-2/1000 infants are born 
      with hearing loss and infants admitted to the neonatal unit for 48 h or more have 
      increased prevalence of hearing loss (1 in 100 live births). * Identification of 
      risk factors in infants admitted to neonatal unit would help with risk 
      stratification and further management. What is New: * In our study, infants 
      admitted to the neonatal unit had higher prevalence of hearing loss (6.3 in 100 
      live births). * In infants across all gestational age "any ventilation episodes", 
      presence of seizures, and severe congenital anomalies were associated with a 
      statistically significant increase in prevalence of hearing loss. Higher 
      prevalence of hearing loss was noted in preterm infants (<32 weeks) who received 
      furosemide treatment and lower prevalence was noted with antenatal use of 
      magnesium sulphate.
FAU - Nair, Vrinda
AU  - Nair V
AD  - James Cook University Hospital, Middlesbrough, UK.
AD  - Clinical Academic Office, Faculty of Medical Sciences, Newcastle University, 
      Newcastle upon Tyne, UK.
FAU - Janakiraman, Sundaram
AU  - Janakiraman S
AD  - James Cook University Hospital, Middlesbrough, UK.
AD  - Clinical Academic Office, Faculty of Medical Sciences, Newcastle University, 
      Newcastle upon Tyne, UK.
FAU - Whittaker, Sarah
AU  - Whittaker S
AD  - Newborn Hearing Screening Programme, Co. Durham, Tees Valley, Hambleton and 
      Richmondshire, UK.
FAU - Quail, Jenna
AU  - Quail J
AD  - Audiology Department, James Cook University Hospital, Middlesbrough, UK.
FAU - Foster, Trevor
AU  - Foster T
AD  - Audiology Department, James Cook University Hospital, Middlesbrough, UK.
FAU - Loganathan, Prakash Kannan
AU  - Loganathan PK
AUID- ORCID: 0000-0003-3717-8569
AD  - James Cook University Hospital, Middlesbrough, UK. pkannanloganathan@nhs.net.
AD  - Clinical Academic Office, Faculty of Medical Sciences, Newcastle University, 
      Newcastle upon Tyne, UK. pkannanloganathan@nhs.net.
LA  - eng
PT  - Journal Article
DEP - 20210216
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
SB  - IM
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - *Hearing Loss/diagnosis/epidemiology/etiology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - *Intensive Care Units, Neonatal
MH  - Neonatal Screening
MH  - Pregnancy
OTO - NOTNLM
OT  - Neonatal intensive care unit
OT  - Permanent childhood hearing impairment
EDAT- 2021/02/18 06:00
MHDA- 2021/06/24 06:00
CRDT- 2021/02/17 05:58
PHST- 2020/10/27 00:00 [received]
PHST- 2021/02/04 00:00 [accepted]
PHST- 2021/02/01 00:00 [revised]
PHST- 2021/02/18 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2021/02/17 05:58 [entrez]
AID - 10.1007/s00431-021-03983-7 [pii]
AID - 10.1007/s00431-021-03983-7 [doi]
PST - ppublish
SO  - Eur J Pediatr. 2021 Jul;180(7):2083-2089. doi: 10.1007/s00431-021-03983-7. Epub 
      2021 Feb 16.