PMID- 33595153
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20210628
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 35
IP  - 6
DP  - 2021 Jun
TI  - Piper nigrum extract attenuates food allergy by decreasing Th2 cell response and 
      regulating the Th17/Treg balance.
PG  - 3214-3225
LID - 10.1002/ptr.7034 [doi]
AB  - Piper nigrum is extensively utilized because of its antioxidation, antiallergic, 
      antitumor, antiinflammatory, antidiarrhea, and gastrointestinal protection. We 
      attempted to indicate whether the Piper nigrum extract (PNE) could alleviate 
      ovalbumin (OVA)-induced food allergy, and to explore its potential mechanism. An 
      OVA-induced food allergy mouse model was established, and different 
      concentrations of PNE were administrated. Symptoms of food allergy, levels of 
      immunoglobulin E (IgE), mucosal mast cell protease-1 (mMCP-1), and intestine 
      pathological changes were assessed. Additionally, the expressions of T helper 
      (Th) 2, Th17 and regulatory T (Treg)-associated cytokines and the proportion of 
      Th17 and Treg cells in CD4(+) T cells were measured. We found PNE attenuated 
      symptoms of food allergy and decreased the levels of IgE and mMCP-1. In PNE 
      group, the infiltration degree of inflammatory cells was ameliorated and the 
      villi of small intestine were more complete. Moreover, the expressions of Th2 and 
      Th17 cell-associated cytokines were down-regulated by PNE pretreatment, while the 
      levels of Treg cell-associated cytokines were up-regulated. PNE decreased the 
      number of Th17 cells, while increased the Tregs cells. PNE treatment 
      dose-dependently improved the Th17/Treg balance. PNE plays a protective role in 
      OVA-induced food allergy through inhibiting Th2 cell response and regulating the 
      Th17/Treg balance.
CI  - (c) 2021 John Wiley & Sons, Ltd.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital 
      and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Jia, Xiaoxiao
AU  - Jia X
AUID- ORCID: 0000-0003-1092-8323
AD  - Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital 
      and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Yu, Qing
AU  - Yu Q
AD  - Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital 
      and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Shen, Sijia
AU  - Shen S
AD  - Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital 
      and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Gao, Yuyan
AU  - Gao Y
AD  - Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital 
      and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Lin, Xixi
AU  - Lin X
AD  - Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Zhang, Weixi
AU  - Zhang W
AUID- ORCID: 0000-0002-1686-1169
AD  - Department of Pediatric Allergy and Immunology, The Second Affiliated Hospital 
      and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
LA  - eng
GR  - 81803544/National Natural Science Foundation of China/
GR  - Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health 
      Talents/
PT  - Journal Article
DEP - 20210217
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*pharmacology
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Antioxidants/metabolism
MH  - Cytokines/metabolism
MH  - Female
MH  - Food Hypersensitivity/*prevention & control
MH  - Immunoglobulin E/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin
MH  - Piper nigrum/*chemistry
MH  - Plant Extracts/*pharmacology
MH  - T-Lymphocytes, Regulatory/metabolism
MH  - Th17 Cells/immunology
MH  - Th2 Cells/immunology
OTO - NOTNLM
OT  - Piper nigrum extract
OT  - Th17
OT  - Th2
OT  - Treg
OT  - food allergy
EDAT- 2021/02/18 06:00
MHDA- 2021/06/29 06:00
CRDT- 2021/02/17 08:56
PHST- 2020/12/23 00:00 [revised]
PHST- 2020/07/28 00:00 [received]
PHST- 2021/01/12 00:00 [accepted]
PHST- 2021/02/18 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/02/17 08:56 [entrez]
AID - 10.1002/ptr.7034 [doi]
PST - ppublish
SO  - Phytother Res. 2021 Jun;35(6):3214-3225. doi: 10.1002/ptr.7034. Epub 2021 Feb 17.