PMID- 33596146
OWN - NLM
STAT- MEDLINE
DCOM- 20220105
LR  - 20220105
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 46
IP  - 8
DP  - 2021 Aug
TI  - The acute and postprandial effects of sugar moiety on vascular and metabolic 
      health outcomes in adolescents.
PG  - 906-914
LID - 10.1139/apnm-2020-0853 [doi]
AB  - This study explored the cardiometabolic responses to sugar moieties acutely, and 
      following a subsequent mixed meal tolerance test (MMTT). Twenty-one healthy 
      adolescents (N = 10 female, 14.3 +/- 0.4 years) completed 3 experimental and 1 
      control condition, in a counterbalanced order. These consisted of different 
      drinks to compare the effect of 300 mL of water (control), or 300 mL of water 
      mixed with 60 g of glucose, fructose or sucrose, on vascular function 
      (flow-mediated dilation (FMD), microvascular reactivity (total hyperaemic 
      response; TRH), and cerebrovascular reactivity (CVR)), and blood samples for uric 
      acid, glucose, triglycerides and lactate concentrations. FMD increased 1 h after 
      glucose and sucrose (P < 0.001, ES >/= 0.92) but was unchanged following fructose 
      and water (P >/= 0.19, ES >/= 0.09). CVR and TRH were unchanged 1 h following all 
      conditions (P > 0.57, effect size (ES) > 0.02). Following the MMTT, FMD was 
      impaired in all conditions (P < 0.001, ES > 0.40) with no differences between 
      conditions (P > 0.13, ES < 0.39). Microvascular TRH was increased in all 
      conditions (P = 0.001, ES = 0.88), and CVR was preserved in all conditions after 
      MMTT (P = 0.87, ES = 0.02). Blood uric acid concentration was elevated following 
      fructose consumption and the MMTT (P < 0.01, ES > 0.40). Consumption of a sugar 
      sweetened beverage did not result in vascular dysfunction in healthy adolescents; 
      however, the vascular and metabolic responses were dependent on sugar moiety. 
      Novelty: Glucose consumption acutely increases peripheral vascular function in 
      healthy adolescents. Acute sugar sweetened beverage consumption (sucrose) does 
      not result in adverse vascular outcomes. Elevations in uric acid are observed 
      with fructose consumption, which may have implications over repeated exposure.
FAU - Koep, Jodie L
AU  - Koep JL
AD  - Children's Health and Exercise Research Centre, Sport and Health Sciences, 
      College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, 
      UK.
AD  - School of Human Movement and Nutrition Sciences, University of Queensland, Saint 
      Lucia, QLD, Australia.
FAU - Barker, Alan R
AU  - Barker AR
AD  - Children's Health and Exercise Research Centre, Sport and Health Sciences, 
      College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, 
      UK.
FAU - Banks, Rhys
AU  - Banks R
AD  - Children's Health and Exercise Research Centre, Sport and Health Sciences, 
      College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, 
      UK.
FAU - Banger, Rohit R
AU  - Banger RR
AD  - Children's Health and Exercise Research Centre, Sport and Health Sciences, 
      College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, 
      UK.
FAU - Lester, Alice
AU  - Lester A
AD  - Children's Health and Exercise Research Centre, Sport and Health Sciences, 
      College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, 
      UK.
FAU - Sansum, Kate M
AU  - Sansum KM
AD  - Children's Health and Exercise Research Centre, Sport and Health Sciences, 
      College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, 
      UK.
FAU - Weston, Max E
AU  - Weston ME
AD  - Children's Health and Exercise Research Centre, Sport and Health Sciences, 
      College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, 
      UK.
AD  - School of Human Movement and Nutrition Sciences, University of Queensland, Saint 
      Lucia, QLD, Australia.
FAU - Bond, Bert
AU  - Bond B
AD  - Children's Health and Exercise Research Centre, Sport and Health Sciences, 
      College of Life and Environmental Sciences, University of Exeter, Exeter EX1 2LU, 
      UK.
LA  - eng
PT  - Journal Article
DEP - 20210217
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Triglycerides)
RN  - 059QF0KO0R (Water)
RN  - 268B43MJ25 (Uric Acid)
RN  - 30237-26-4 (Fructose)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 57-50-1 (Sucrose)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adolescent
MH  - Beverages
MH  - Female
MH  - Fructose/blood/*pharmacology
MH  - Glucose/metabolism/*pharmacology
MH  - Humans
MH  - Lactic Acid/blood
MH  - Male
MH  - Microvessels/*drug effects
MH  - *Postprandial Period
MH  - Sucrose/blood/*pharmacology
MH  - Triglycerides/blood
MH  - Uric Acid/blood
MH  - Vascular Resistance/*drug effects
MH  - Water/administration & dosage
OTO - NOTNLM
OT  - FMD
OT  - adolescents
OT  - boisson sucree
OT  - cardiovascular disease
OT  - endothelial function
OT  - fonction endotheliale
OT  - fonction vasculaire
OT  - fructose
OT  - glucose
OT  - hyperglycaemia
OT  - hyperglycemie
OT  - maladies cardiovasculaires
OT  - saccharose
OT  - sucrose
OT  - sugar sweetened beverage
OT  - vascular function
EDAT- 2021/02/18 06:00
MHDA- 2022/01/06 06:00
CRDT- 2021/02/17 17:09
PHST- 2021/02/18 06:00 [pubmed]
PHST- 2022/01/06 06:00 [medline]
PHST- 2021/02/17 17:09 [entrez]
AID - 10.1139/apnm-2020-0853 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2021 Aug;46(8):906-914. doi: 10.1139/apnm-2020-0853. 
      Epub 2021 Feb 17.