PMID- 33596907
OWN - NLM
STAT- MEDLINE
DCOM- 20210802
LR  - 20210802
IS  - 1746-6148 (Electronic)
IS  - 1746-6148 (Linking)
VI  - 17
IP  - 1
DP  - 2021 Feb 17
TI  - Antibody responses to porcine reproductive and respiratory syndrome virus, 
      influenza A virus, and Mycoplasma hyopneumoniae from weaning to the end of the 
      finisher stage in fourteen groups of pigs in Ontario, Canada.
PG  - 82
LID - 10.1186/s12917-021-02756-6 [doi]
LID - 82
AB  - BACKGROUND: Respiratory diseases are among the most important factors affecting 
      swine farm productivity in Canada. The objectives of this study were to 
      investigate antibody responses to porcine reproductive and respiratory syndrome 
      virus (PRRSV), influenza A virus (IAV), and Mycoplasma hyopneumoniae (M. 
      hyopneumoniae) from weaning to the end of the finisher stage on a subset of 
      commercial swine farms in Ontario, Canada, and to examine the association between 
      nursery diet and antibody responses. RESULTS: Overall, older pigs were more 
      likely to test seropositive for PRRSV and less likely to test seropositive for M. 
      hyopneumoniae (p <  0.001). Pigs were more likely to test seropositive for IAV at 
      weaning and the end of the grower and finisher stages compared to the end of 
      nursery (p <  0.001). Pigs that were seropositive for IAV were more likely to 
      test seropositive for both PRRSV and M. hyopneumoniae (p <  0.001). Two, 9, and 4 
      groups that had more than 20% of pigs seropositive to PRRSV, IAV, and M. 
      hyopneumoniae, respectively, from the end of nursery to the end of finisher were 
      classified as seropositive. Pigs fed a plant-based (low complexity) diet during 
      nursery were more likely to be seropositive for PRRSV (p <  0.001) but there were 
      no significant differences in seropositivity to IAV or M. hyopneumoniae due to 
      nursery diet complexity. CONCLUSIONS: This study provides information regarding 
      changes in serum antibody in pigs across different stages of production and 
      highlights periods of vulnerability. Additionally, these findings may encourage 
      further research into the effects of nursery diet complexity on disease 
      susceptibility and immune response.
FAU - Raaphorst, Elana
AU  - Raaphorst E
AD  - Department of Pathobiology, University of Guelph, 50 Stone Road East, Guelph, ON, 
      N1G 2W1, Canada.
FAU - Farzan, Abdolvahab
AU  - Farzan A
AUID- ORCID: 0000-0002-9612-0263
AD  - Department of Pathobiology, University of Guelph, 50 Stone Road East, Guelph, ON, 
      N1G 2W1, Canada. afarzan@uoguelph.ca.
AD  - Department of Population Medicine, University of Guelph, 50 Stone Rd E, Guelph, 
      ON, N1G 2W1, Canada. afarzan@uoguelph.ca.
FAU - Friendship, Robert M
AU  - Friendship RM
AD  - Department of Population Medicine, University of Guelph, 50 Stone Rd E, Guelph, 
      ON, N1G 2W1, Canada.
FAU - Lillie, Brandon N
AU  - Lillie BN
AD  - Department of Pathobiology, University of Guelph, 50 Stone Road East, Guelph, ON, 
      N1G 2W1, Canada.
LA  - eng
GR  - 488429-15/Natural Sciences and Engineering Research Council of Canada/
GR  - UofG2013-1472/Ontario Ministry of Agriculture, Food and Rural Affairs/
GR  - 15/015/Ontario Pork/
GR  - 1239e/Swine Innovation Porc/
PT  - Journal Article
DEP - 20210217
PL  - England
TA  - BMC Vet Res
JT  - BMC veterinary research
JID - 101249759
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Animal Feed/analysis
MH  - Animal Husbandry/methods
MH  - Animals
MH  - Antibodies, Bacterial/blood
MH  - Antibodies, Viral/blood
MH  - Antibody Formation
MH  - Diet/*veterinary
MH  - Influenza A virus/isolation & purification
MH  - Mycoplasma hyopneumoniae/isolation & purification
MH  - Ontario/epidemiology
MH  - Orthomyxoviridae Infections/immunology/*veterinary
MH  - Pneumonia of Swine, Mycoplasmal/*immunology
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/isolation & purification
MH  - Swine
MH  - Swine Diseases/epidemiology/*immunology/microbiology/virology
PMC - PMC7887834
OTO - NOTNLM
OT  - Antibody response
OT  - ELISA
OT  - Influenza A virus
OT  - Mycoplasma hyopneumoniae
OT  - Nursery diet
OT  - Porcine reproductive and respiratory syndrome
OT  - swine
COIS- The authors declare that they have no competing interests.
EDAT- 2021/02/19 06:00
MHDA- 2021/08/03 06:00
PMCR- 2021/02/17
CRDT- 2021/02/18 05:45
PHST- 2020/03/13 00:00 [received]
PHST- 2021/01/11 00:00 [accepted]
PHST- 2021/02/18 05:45 [entrez]
PHST- 2021/02/19 06:00 [pubmed]
PHST- 2021/08/03 06:00 [medline]
PHST- 2021/02/17 00:00 [pmc-release]
AID - 10.1186/s12917-021-02756-6 [pii]
AID - 2756 [pii]
AID - 10.1186/s12917-021-02756-6 [doi]
PST - epublish
SO  - BMC Vet Res. 2021 Feb 17;17(1):82. doi: 10.1186/s12917-021-02756-6.