PMID- 3359696
OWN - NLM
STAT- MEDLINE
DCOM- 19880602
LR  - 20131121
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 29
IP  - 2
DP  - 1988 Feb
TI  - Dialysis-induced change in erythrocyte volume: effect on change in blood volume 
      calculated from packed cell volume.
PG  - 63-8
AB  - Blood volume (BV) change during hemodialysis is often monitored by packed cell 
      volume (PCV). This assumes erythrocyte volume is constant. We tested this by 
      dialyzing 5 patients for 2 hours against high (154 mmol/l), normal (140 mmol/l) 
      and low (126 mmol/l) dialysate sodium concentrations. Erythrocyte water content, 
      calculated from measured blood and plasma water contents, decreased with high and 
      increased with low dialysate sodium concentrations. Erythrocyte volume, 
      calculated from mean corpuscular hemoglobin concentration (MCHC) decreased 3.8% 
      with high concentration dialysate and increased 2.5% when dialysate concentration 
      was low. These changes correlated significantly (r = 0.80, p less than 0.01) with 
      alterations in plasma sodium. Mean corpuscular volume (MCV), measured with a 
      Coulter-S Plus Counter did not alter because of a methodological artefact. BV 
      change can be calculated from PCV when plasma concentrations of osmotically 
      active substances are changed only if allowance is made for altered erythrocyte 
      volume.
FAU - Fleming, S J
AU  - Fleming SJ
AD  - Department of Nephrology, St. Bartholomews Hospital, London, England.
FAU - Wilkinson, J S
AU  - Wilkinson JS
FAU - Aldridge, C
AU  - Aldridge C
FAU - Greenwood, R N
AU  - Greenwood RN
FAU - Muggleston, S D
AU  - Muggleston SD
FAU - Baker, L R
AU  - Baker LR
FAU - Cattell, W R
AU  - Cattell WR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Adult
MH  - *Blood Volume
MH  - *Erythrocyte Indices
MH  - *Erythrocyte Volume
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - *Renal Dialysis
MH  - Sodium/pharmacology
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
PST - ppublish
SO  - Clin Nephrol. 1988 Feb;29(2):63-8.