PMID- 33597467
OWN - NLM
STAT- MEDLINE
DCOM- 20210930
LR  - 20210930
IS  - 2521-9855 (Electronic)
IS  - 0127-5720 (Linking)
VI  - 36
IP  - 4
DP  - 2019 Dec 1
TI  - Therapeutic efficacy of seaweed extract (Ulva Fasciata Delile) against invasive 
      candidiasis in mice.
PG  - 972-986
AB  - Candida is the most frequent common causes of invasive fungal infections and 
      associated with high morbidity and mortality. Most of available antifungal agents 
      have side effects. This opened up new avenues to investigate the antifungal 
      efficacy of active extracts from marine algae. So the aim of this study was to 
      evaluate the protective and the curative effect of Ulva fasciata extract against 
      an invasive candidiasis in mice and to study its underlying mechanism. The active 
      ingredients of Ulva fasciata extract were evaluated using HPLC and GC/MS. Fifty 
      mice were included in current work, and the level of inflammatory markers; 
      Interleukin (IL)-4, IL-12, Interferon-gamma (IFN-gamma) and Tumor necrosis 
      factor-alpha (TNF-alpha) were determined using ELISA kits. Hematological, biochemical 
      and oxidative stress parameters were determined using commercial kits. Moreover, 
      the histopathological examinations were carried on liver, kidney and spleen for 
      all groups. The results obtained showed that treatment with U. fasciata either 
      before or after Candida infection significantly improved the hematological, 
      biochemical alterations and antioxidant status caused by this infection. 
      Furthermore, the U. fasciata reduced histopathological changes induced by Candida 
      as well as it could increase the expression of IL-12 and IFN-gamma while minimized 
      the expression of TNF-alpha and IL-4 in all infected mice compared to infected 
      untreated mice. These data propose that U. fasciata can ameliorate inflammatory 
      reactions related to Candida albicans cytotoxicity via its ability to augment 
      cellular antioxidant defenses by its active compounds.
FAU - Fathy, S A
AU  - Fathy SA
AD  - Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
FAU - Mohamed, M R
AU  - Mohamed MR
AD  - Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
FAU - Emam, M A
AU  - Emam MA
AD  - Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
FAU - Mohamed, S S
AU  - Mohamed SS
AD  - Microbiology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
FAU - Ghareeb, D A
AU  - Ghareeb DA
AD  - Bioscreening and Preclinical Trial Lab, Biochemistry Department, Faculty of 
      Science, Alexandria University, Egypt, Pharmaceutical and Fermentation Industries 
      Development Centre, The City of Scientific Research and Technological 
      Applications, Alexandria, Egypt.
FAU - Elgohary, S A
AU  - Elgohary SA
AD  - Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
FAU - Abd-El Megeed, D F
AU  - Abd-El Megeed DF
AD  - Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
LA  - eng
PT  - Journal Article
PL  - Malaysia
TA  - Trop Biomed
JT  - Tropical biomedicine
JID - 8507086
RN  - 0 (Antifungal Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 187348-17-0 (Interleukin-12)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antifungal Agents/*pharmacology
MH  - Antioxidants/metabolism
MH  - Candida albicans
MH  - Candidiasis, Invasive/*drug therapy
MH  - Interferon-gamma/metabolism
MH  - Interleukin-12/metabolism
MH  - Interleukin-4/metabolism
MH  - Male
MH  - Mice
MH  - Plant Extracts/*pharmacology
MH  - Seaweed/chemistry
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Ulva/*chemistry
EDAT- 2019/12/01 00:00
MHDA- 2021/10/01 06:00
CRDT- 2021/02/18 05:56
PHST- 2021/02/18 05:56 [entrez]
PHST- 2019/12/01 00:00 [pubmed]
PHST- 2021/10/01 06:00 [medline]
PST - ppublish
SO  - Trop Biomed. 2019 Dec 1;36(4):972-986.