PMID- 33597492
OWN - NLM
STAT- MEDLINE
DCOM- 20210929
LR  - 20210929
IS  - 2521-9855 (Electronic)
IS  - 0127-5720 (Linking)
VI  - 36
IP  - 3
DP  - 2019 Sep 1
TI  - Human leukocyte antigen (HLA) class II association in chronic hepatitis B 
      patients with hepatocellular carcinoma in a Malay population: A pilot study.
PG  - 703-708
AB  - Asian countries account for almost three quarter of hepatocellular carcinoma 
      (HCC) reported globally and chronic hepatitis B infection is one of the main 
      contributors. Clinical observations show that Malay patients with chronic 
      hepatitis B and HCC tend to have a worse outcome, when compared to other two 
      major races in Malaysia. The objectives of this study was to determine the 
      frequency of human leukocyte antigen (HLA) class II alleles in chronic hepatitis 
      B patients with HCC among Malays compared to the general population to identify 
      potential associations of HLA alleles with this disease. HLA class II typing was 
      performed in chronic hepatitis B patients with hepatocellular carcinoma (n=12) by 
      -polymerase chain reaction, sequence specific primer (PCR-SSP) method. There were 
      higher allelic frequencies of certain HLA-DQB1 and HLA-DRB1 alleles; HLA-DQB1*03 
      (07) (41.7%), and HLA-DRB1*12 (41.7% vs 28.6%) and compared to controls (41.7% vs 
      29.7%). However, there was no significant statistical correlation found when 
      compared with the normal healthy general population. This study provides an 
      insight into the HLA Class II association with chronic hepatitis B and 
      hepatocellular carcinoma in Malays. However, findings from this study should be 
      validated with a larger number of samples using a high resolution HLA typing.
FAU - Krishnan, P B
AU  - Krishnan PB
AD  - Department of Medical Microbiology and Parasitology, Faculty of Medicine and 
      Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
AD  - Allergy and Immunology Research Centre, Institute for Medical Research, Kuala 
      Lumpur, Malaysia.
FAU - Abdullah, M
AU  - Abdullah M
AD  - Department of Pathology, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, Selangor, Malaysia.
FAU - Hudu, S A
AU  - Hudu SA
AD  - 3Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical 
      Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, 840232 
      Sokoto State, Nigeria.
FAU - Sekawi, Z
AU  - Sekawi Z
AD  - Department of Medical Microbiology and Parasitology, Faculty of Medicine and 
      Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
FAU - Tan, S S
AU  - Tan SS
AD  - Department of Hepatology, Hospital Selayang, Selangor, Malaysia.
FAU - Amin-Nordin, S
AU  - Amin-Nordin S
AD  - Department of Medical Microbiology and Parasitology, Faculty of Medicine and 
      Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
LA  - eng
PT  - Journal Article
PL  - Malaysia
TA  - Trop Biomed
JT  - Tropical biomedicine
JID - 8507086
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Carcinoma, Hepatocellular/*genetics/virology
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Hepatitis B, Chronic/*genetics
MH  - Humans
MH  - Liver Neoplasms/*genetics/virology
MH  - Malaysia
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
EDAT- 2019/09/01 00:00
MHDA- 2021/09/30 06:00
CRDT- 2021/02/18 05:56
PHST- 2021/02/18 05:56 [entrez]
PHST- 2019/09/01 00:00 [pubmed]
PHST- 2021/09/30 06:00 [medline]
PST - ppublish
SO  - Trop Biomed. 2019 Sep 1;36(3):703-708.