PMID- 33598778
OWN - NLM
STAT- MEDLINE
DCOM- 20210819
LR  - 20210819
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 25
IP  - 9
DP  - 2021 Sep
TI  - Clinical and radiographic evaluation of 0.8% hyaluronic acid as an adjunct to 
      open flap debridement in the treatment of periodontal intrabony defects: 
      randomized controlled clinical trial.
PG  - 5257-5271
LID - 10.1007/s00784-021-03834-7 [doi]
AB  - OBJECTIVES: Present study aimed to evaluate and compare the clinical and 
      radiographic efficacy of 0.8% hyaluronic acid (HA) gel as an adjunct to open flap 
      debridement (OFD) versus open flap debridement (OFD) alone in the treatment of 
      periodontal intrabony defects. MATERIALS AND METHODS: This randomized, 
      controlled, split-mouth, clinical trial included 20 chronic periodontitis (stage 
      II or III (grades A to B)) patients, having at least two contralateral intrabony 
      defects. Forty bilateral intrabony defects (20 in each group) were randomly 
      divided into test (0.8% HA gel + OFD) and control (OFD + placebo) groups. 
      Clinical parameters evaluated at baseline, 6-months, and 12-months were plaque 
      index (PI), gingival index (GI), probing depth (PD), clinical attachment level 
      (CAL), and gingival recession (GR). Using cone beam computed tomography (CBCT), 
      radiographic parameters were evaluated at baseline and 12 months. This included 
      bone defect fill (DF), alveolar crest changes (ACC), and defect resolution (DR). 
      CAL served as the primary outcome variable. RESULTS: After 12 months, the test 
      group showed significantly greater CAL gain (5.1 +/- 1.2 versus 4.05 +/- 1.19 mm) and 
      bone defect fill (DF) (5.67 +/- 2.01 versus 4.49 +/- 1.78 mm) compared to the control 
      group. Mean PD reduction in the test group (5.3 +/- 1.2 versus 4.35 +/- 0.81 mm) was 
      statistically significant compared to the control group at 12-month period. The 
      control group showed statistically significant increase in GR (1.2 +/- 0.76 versus 
      0.7 +/- 0.73 mm) compared to the test group after 12 months. CONCLUSION: 
      Application of hyaluronic acid gel in conjunction with open flap debridement 
      resulted in enhanced clinical and radiographic outcomes compared to open flap 
      debridement alone. CLINICAL RELEVANCE: Adjunctive application of HA gel in open 
      flap debridement may improve clinical and radiographic outcomes. CLINICAL TRIAL 
      REGISTERED NUMBER: CTRI/2018/03/012334.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part 
      of Springer Nature.
FAU - Mamajiwala, Alefiya S
AU  - Mamajiwala AS
AD  - Department of Periodontology and Oral Implantology, Karmaveer Bhausaheb Hiray 
      Dental College and Hospital, Nashik, Maharashtra, India.
FAU - Sethi, Kunal S
AU  - Sethi KS
AD  - Department of Periodontology and Oral Implantology, Karmaveer Bhausaheb Hiray 
      Dental College and Hospital, Nashik, Maharashtra, India.
FAU - Raut, Chetan P
AU  - Raut CP
AUID- ORCID: 0000-0003-2517-7681
AD  - Department of Periodontology and Oral Implantology, Karmaveer Bhausaheb Hiray 
      Dental College and Hospital, Nashik, Maharashtra, India. craut96@gmail.com.
FAU - Karde, Prerna A
AU  - Karde PA
AD  - Department of Periodontology and Oral Implantology, Karmaveer Bhausaheb Hiray 
      Dental College and Hospital, Nashik, Maharashtra, India.
FAU - Mamajiwala, Batul S
AU  - Mamajiwala BS
AD  - Department of Public Health Dentistry, Government Dental College and Hospital, 
      Mumbai, India.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20210217
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - 9004-61-9 (Hyaluronic Acid)
MH  - *Alveolar Bone Loss/diagnostic imaging/surgery
MH  - Debridement
MH  - Follow-Up Studies
MH  - *Gingival Recession/surgery
MH  - Guided Tissue Regeneration, Periodontal
MH  - Humans
MH  - Hyaluronic Acid
MH  - Periodontal Attachment Loss
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Chronic periodontitis
OT  - Hyaluronic acid
OT  - Periodontal bone loss
OT  - Periodontal debridement
OT  - Periodontal regeneration
OT  - Randomized controlled trial
EDAT- 2021/02/19 06:00
MHDA- 2021/08/20 06:00
CRDT- 2021/02/18 06:14
PHST- 2020/10/16 00:00 [received]
PHST- 2021/02/08 00:00 [accepted]
PHST- 2021/02/19 06:00 [pubmed]
PHST- 2021/08/20 06:00 [medline]
PHST- 2021/02/18 06:14 [entrez]
AID - 10.1007/s00784-021-03834-7 [pii]
AID - 10.1007/s00784-021-03834-7 [doi]
PST - ppublish
SO  - Clin Oral Investig. 2021 Sep;25(9):5257-5271. doi: 10.1007/s00784-021-03834-7. 
      Epub 2021 Feb 17.